Concurrence of Danish dementia and cataract: insights from the interactions of dementia associated peptides with eye lens alpha-crystallin. [PDF]
PLoS ONE, 2008 Familial Danish Dementia (FDD) is an autosomal disease, which is distinguished by gradual loss of vision, deafness, progressive ataxia and dementia. Cataract is the first manifestation of the disease.
Ira Surolia +5 more
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Multiple aggregates and aggresomes of C-terminal truncated human αA-crystallins in mammalian cells and protection by αB-crystallin. [PDF]
PLoS ONE, 2011 Cleavage of 11 (αA162), 5 (αA168) and 1 (αA172) residues from the C-terminus of αA-crystallin creates structurally and functionally different proteins. The formation of these post-translationally modified αA-crystallins is enhanced in diabetes.
Ilangovan Raju +2 more
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Crystallins and neuroinflammation: the glial side of the story
Biochimica et Biophysica Acta, 2015 Background There is an abundance of evidence to support the association of damaging neuroinflammation and neurodegeneration across a multitude of diseases.
Jennifer E. Dulle, P. Fort
semanticscholar +1 more source
Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions
TIBS -Trends in Biochemical Sciences. Regular ed, 2011 The small heat shock proteins (sHSPs) and the related α-crystallins (αCs) are virtually ubiquitous proteins that are strongly induced by a variety of stresses, but that also function constitutively in multiple cell types in many organisms.
E. Basha +2 more
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Analysis and update of the human aldehyde dehydrogenase (
Human Genomics, 2005 The aldehyde dehydrogenase (ALDH) gene superfamily encodes enzymes that are critical for certain life processes and detoxification via the NAD(P)+-dependent oxidation of numerous endogenous and exogenous aldehyde substrates, including pharmaceuticals and
Vasiliou Vasilis, Nebert Daniel W
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Cataract-causing defect of a mutant γ-crystallin proceeds through an aggregation pathway which bypasses recognition by the α-crystallin chaperone. [PDF]
PLoS ONE, 2012 The transparency of the eye lens depends upon maintenance of the native state of the γ- and β-crystallins, which is aided by the abundant chaperones αA- and αB-crystallin.
Kate L Moreau, Jonathan A King
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The βγ-crystallins: Native state stability and pathways to aggregation
Progress in Biophysics and Molecular Biology, 2014 The βγ-crystallins are among the most stable and long-lived proteins in the human body. With increasing age, however, they transform to high molecular weight light-scattering aggregates, resulting in cataracts.
Eugene Serebryany, J. King
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Identification and functional analysis of αB-crystallins in Pteromalus puparum
Frontiers in Physiology, 2023 Heat shock proteins, including αB-crystallins (CRYAB), are pivotal in cellular defense mechanisms and stress response. This study presents a comprehensive investigation of heat shock proteins (HSPs), with a specific focus on the CRYAB family, within the ...
Shuxing Lao +3 more
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PLoS ONE, 2020 Parkinson´s disease is characterized by the accumulation of proteinaceous aggregates in Lewy bodies and Lewy Neurites. The main component found in such aggregates is α-synuclein.
Ricardo Gaspar +2 more
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An Insight on α-crystallin Interactions with Various Proteins in Systemic Disorders [PDF]
Journal of Stress Physiology & Biochemistry, 2023 αA- and αB- crystallins are the two principal components of the α-crystallin family of heat shock proteins which exhibit chaperone activity as well as cyto-protective function.
Aparajita Chakraborty +3 more
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