Results 41 to 50 of about 6,105 (219)
Aggregation pathways of human γ D crystallin induced by metal ions revealed by time dependent methods [PDF]
PeerJ, 2020 Cataract formation is a slow accumulative process due to protein aggregates promoted by different factors over time. Zinc and copper ions have been reported to induce the formation of aggregates opaque to light in the human gamma D crystallin (HγD) in a ...
Arline Fernández-Silva +3 more
doaj +2 more sources
CRYSTALLINE RIBONUCLEASE [PDF]
Journal of General Physiology, 1940 1. A crystalline enzyme capable of digesting yeast nucleic acid has been isolated from fresh beef pancreas. 2. The enzyme called "ribonuclease" is a soluble protein of albumin type. Its molecular weight is about 15,000. Its isoelectric point is in the region of pH 8.0. 3.
openaire +2 more sources
Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer
Medicinal Research Reviews, EarlyView.ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek +3 more
wiley +1 more source
Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus
Pest Management Science, EarlyView.Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano +7 more
wiley +1 more source
In vitro interactions of histones and α-crystallin
Biochemistry and Biophysics Reports, 2018 The aggregation of crystallins in lenses is associated with cataract formation. We previously reported that mutant crystallins are associated with an increased abundance of histones in knock-in and knockout mouse models.
Paul D. Hamilton, Usha P. Andley
doaj +1 more source
Crystallins are regulated biomarkers for monitoring topical therapy of glaucomatous optic neuropathy. [PDF]
PLoS ONE, 2013 Optic nerve atrophy caused by abnormal intraocular pressure (IOP) remains the most common cause of irreversible loss of vision worldwide. The aim of this study was to determine whether topically applied IOP-lowering eye drugs affect retinal ganglion ...
Verena Prokosch +2 more
doaj +1 more source
Ubiquitous lens α-, β-, and γ-crystallins accumulate in anuran cornea as corneal crystallins
, 2007 Corneal epithelium is known to have high levels of some metabolic enzymes such as aldehyde dehydrogenase in mammals, gelsolin in zebrafish, and α-enolase in several species.
Aggrawal, Ramesh K. +6 more
core +1 more source
Functional Role of γ-Crystallin N in the Auditory Hindbrain. [PDF]
PLoS ONE, 2016 γ-crystallins are major components of the vertebrate lens but show expression in other tissues as well. Their extralenticular functions remain so far unclear.
Heiner Hartwich +5 more
doaj +1 more source
Integrated Multi‐Omics Analysis Reveals the Genetic Basis of Phenotypic Variation in Tibetan Sheep
Integrative Zoology, EarlyView.SNaPshot‐validated GWAS results demonstrated significant correlations between candidate single nucleotide polymorphisms (SNPs) and body size traits in Tibetan sheep. Concurrently, hematoxylin and eosin staining, alongside muscle fiber analysis, confirmed pronounced morphological differences in muscle tissue between sheep of varying conformation.
Dehui Liu +16 more
wiley +1 more source
Lens crystallins and oxidation: the special case of γS
, 2001 International audienceAmong lens crystallins, gamma -crystallins are particularly sensitive to oxidation, because of their high amount of Cys and Met residues.
Nicolette H. Lubsen +11 more
core +1 more source