Characterization of γ-crystallins from eye lenses of shark: closer structural similarity to mammalian than other piscine γ-crystallins? [PDF]
, 1989 Lens crystalline were isolated and characterized from sharks of the cartilaginous fishes. Four crystallin fractions corresponding to α-,⨿H-,βL- and γ-crystallins, similar to those of mammalian crystallins, were obtained.
Chiou, S.-H., S.-H. Chiou
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MALDI imaging mass spectrometry of β‐ and γ‐crystallins in the ocular lens [PDF]
, 2020 Lens crystallin proteins make up 90% of expressed proteins in the ocular lens and are primarily responsible for maintaining lens transparency and establishing the gradient of refractive index necessary for proper focusing of images onto the retina.
Paul J. Donaldson +11 more
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Copper reductase activity and free radical chemistry by cataract-associated human lens γ-crystallins [PDF]
, 2022 Cataracts are caused by high-molecular weight aggregates of human eye lens proteins that scatter light, causing lens opacity. Metal ions have emerged as important potential players in the etiology of cataract disease, as human lens γ-crystallins are ...
Giovanni, Palomino-Vizcaino +9 more
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Crystalline and Non-crystalline Solids [PDF]
, 2016 The structural properties of materials play a fundamental role in the determination of their suitability for a specific application. This book is intended as a contribution to the efforts to increase the knowledge of the influence exerted on the properties of materials by their crystalline or amorphous structure. To this aim, some of the materials that
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An Insight on α-crystallin Interactions with Various Proteins in Systemic Disorders [PDF]
Journal of Stress Physiology & Biochemistry, 2023 αA- and αB- crystallins are the two principal components of the α-crystallin family of heat shock proteins which exhibit chaperone activity as well as cyto-protective function.
Aparajita Chakraborty +3 more
doaj
Intravitreal injection of β-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma. [PDF]
PLoS ONE, 2017 Purpose of this study was to investigate firstly specific proteomic changes within the retina in the course of an animal glaucoma model and to identify secondly new approaches for neuroprotective, therapeutic options in glaucoma by addressing those ...
Fabian Anders +8 more
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Calcium binding properties of beta-crystallins [PDF]
, 1996 β-Crystallins, the oligomeric proteins of the eye lens, were found to bind calcium ions with low affinity, in the millimolar range. Calcium was found to induce conformational changes in the secondary and tertiary structure of β-crystallins.
Balasubramanian, D., Sharma, Yogendra
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Aggregation pathways of human γ D crystallin induced by metal ions revealed by time dependent methods [PDF]
PeerJ, 2020 Cataract formation is a slow accumulative process due to protein aggregates promoted by different factors over time. Zinc and copper ions have been reported to induce the formation of aggregates opaque to light in the human gamma D crystallin (HγD) in a ...
Arline Fernández-Silva +3 more
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
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α-Crystallins in the Vertebrate Eye Lens: Complex Oligomers and Molecular Chaperones [PDF]
, 2021 α-Crystallins are small heat-shock proteins that act as holdase chaperones. In humans, αA-crystallin is expressed only in the eye lens, while αB-crystallin is found in many tissues.
Sprague-Piercy, Marc A +3 more
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