An Insight on α-crystallin Interactions with Various Proteins in Systemic Disorders [PDF]
Journal of Stress Physiology & Biochemistry, 2023 αA- and αB- crystallins are the two principal components of the α-crystallin family of heat shock proteins which exhibit chaperone activity as well as cyto-protective function.
Aparajita Chakraborty +3 more
doaj
Intravitreal injection of β-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma. [PDF]
PLoS ONE, 2017 Purpose of this study was to investigate firstly specific proteomic changes within the retina in the course of an animal glaucoma model and to identify secondly new approaches for neuroprotective, therapeutic options in glaucoma by addressing those ...
Fabian Anders +8 more
doaj +1 more source
Crystalline bacterial catalase [PDF]
Biochemical Journal, 1947 It is now fifty-four years since Gottstein1 discovered that some bacteria are able to decompose hydrogen peroxide with evolution of gaseous oxygen, an activity he attributed to their possessing an intracellular enzyme which later came to be called ‘catalase’.
D, Herbert, J, Pinsent
openaire +3 more sources
Aggregation pathways of human γ D crystallin induced by metal ions revealed by time dependent methods [PDF]
PeerJ, 2020 Cataract formation is a slow accumulative process due to protein aggregates promoted by different factors over time. Zinc and copper ions have been reported to induce the formation of aggregates opaque to light in the human gamma D crystallin (HγD) in a ...
Arline Fernández-Silva +3 more
doaj +2 more sources
Changes in zebrafish (Danio rerio) lens crystallin content during development. [PDF]
, 2013 PurposeThe roles that crystallin proteins play during lens development are not well understood. Similarities in the adult crystallin composition of mammalian and zebrafish lenses have made the latter a valuable model for examining lens function.
Corbin, Rebecca W +4 more
core +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Potential of human γD-crystallin for hair damage repair : insights into the mechanical properties and biocompatibility [PDF]
, 2013 The objective of this work was to develop a new strategy to physically ‘repair’ chemically damaged hair. Hence the human eye γD-crystallin, a protein from the superfamily characterized structurally by the Greek key motif, was studied.
Andersson +25 more
core +1 more source
Advanced Science, EarlyView.Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija +22 more
wiley +1 more source
Transcriptional profiling of single fiber cells in a transgenic paradigm of an inherited childhood cataract reveals absence of molecular heterogeneity. [PDF]
, 2019 Our recent single-cell transcriptomic analysis has demonstrated that heterogeneous transcriptional activity attends molecular transition from the nascent to terminally differentiated fiber cells in the developing mouse lens.
Bhat, Suraj P +6 more
core
Tyrosine/Cysteine Cluster Sensitizing Human γD-Crystallin to Ultraviolet Radiation-Induced Photoaggregation in Vitro [PDF]
, 2013 Ultraviolet radiation (UVR) exposure is a major risk factor for age-related cataract, a protein-aggregation disease of the human lens often involving the major proteins of the lens, the crystallins.
King, Jonathan Alan +3 more
core +1 more source