Results 51 to 60 of about 6,105 (219)

CRYAB is compromised in pathologically affected oligodendrocytes in multiple system atrophy

Brain Pathology, EarlyView.
CRYAB is hypermethylated and colocalizes with α‐synuclein in multiple system atrophy oligodendrocytes.
Finula I. Isik, Jen‐Hsiang T. Hsiao, Felicia Xaveria Suteja, Shrey Shahdadpuri, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim, YuHong Fu   +7 more
wiley   +1 more source

Copper reductase activity and free radical chemistry by cataract-associated human lens γ-crystallins [PDF]

, 2022
Cataracts are caused by high-molecular weight aggregates of human eye lens proteins that scatter light, causing lens opacity. Metal ions have emerged as important potential players in the etiology of cataract disease, as human lens γ-crystallins are ...
Giovanni, Palomino-Vizcaino, Jonathan A., King, Thomas, Kroll, Liliana, Quintanar, Oscar, Rodríguez-Meza, Eugene, Serebryany, Eduardo, Martínez-Jurado, Miguel, Costas, Jose A., Domínguez-Calva, Nils, Schuth   +9 more
core   +2 more sources

The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function [PDF]

PeerJ, 2017
Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or ...
Mason Posner, Kelly L. Murray, Matthew S. McDonald, Hayden Eighinger, Brandon Andrew, Amy Drossman, Zachary Haley, Justin Nussbaum, Larry L. David, Kirsten J. Lampi   +9 more
doaj   +2 more sources

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Association of two crystallins in macromolecular crowding.

, 2016
Sketch of two crystallins as reactants polymerising into a dimer as product for (a) thermodynamic perturbation model (TPM), where blue spheres represent crystallins with isotropic intermolecular attraction, and (b) chemical binding model (CBM), where ...
Fan Song (110016), Jure Dobnikar (353496), Jiachen Wei (2557087), Tine Curk (353494)   +3 more
core   +1 more source

Decreased heat stability and increased chaperone requirement of modified human βB1-crystallins

, 2002
Purpose: To determine how deamidation and partial loss of the N- and C-terminal extensions alter the heat stability of βB1-crystallin. Methods: Human lens βB1, a deamidated βB1, Q204E, and αA-crystallins were expressed.
Yung H Kim (20190102), Larry L David (5006747), Deborah M Kapfer (20190117), Thomas R Shearer (20190114), Robyn A Lindner (20190111), Bruce A Boswell (20190108), Kirsten J Lampi (20190099), Hans Peter Bachinger (20190105), John A Carver (13674967)   +8 more
core   +1 more source

Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed βH-Crystallins Polymerization in Calcium-Induced Experimental Cataract [PDF]

, 2020
In an in vitro Ca2+-induced cataract model, the progression of opacification is paralleled by a rapid decrease of the endogenous levels of spermidine (SPD) and an increase of transglutaminase type 2 (TG2, EC 2.3.2.13)-catalyzed lens crystallins cross ...
Angelo De Martino, Giordana Feriotto, Sonia Melino, Carlo Mischiati, Fabio Domenici, Claudio Tabolacci, Cinzia Forni, Simone Beninati, Ilaria Borromeo, Feriotto G., Domenici F., Forni C., Beninati S., Mischiati C., Borromeo I., Tabolacci C., Melino S., De Martino A.   +17 more
core   +2 more sources

Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.

PLoS ONE, 2018
The mammalian eye lens expresses a high concentration of crystallins (α, β and γ-crystallins) to maintain the refractive index essential for lens transparency. Crystallins are long-lived proteins that do not turnover throughout life.
Usha P Andley, Eric Tycksen, Brittney N McGlasson-Naumann, Paul D Hamilton   +3 more
doaj   +1 more source

Cataract-causing mutation S228P promotes βB1-crystallin aggregation and degradation by separating two interacting loops in C-terminal domain

Protein & Cell, 2016
β/γ-Crystallins are predominant structural proteins in the cytoplasm of lens fiber cells and share a similar fold composing of four Greek-key motifs divided into two domains.
Liang-Bo Qi, Li-Dan Hu, Huihui Liu, Hai-Yun Li, Xiao-Yao Leng, Yong-Bin Yan   +5 more
doaj   +1 more source

High‐resolution spatial transcriptomic atlas of mouse soleus muscle: Unveiling single cell and subcellular heterogeneity in health and denervation

The FEBS Journal, EarlyView.
Seq‐Scope maps skeletal muscle transcriptomes at high spatial resolution while preserving histological context, revealing distinct responses of myofibers, neuromuscular junctions, and stromal cells to denervation. This spatial view uncovers fiber type‐specific and localized remodeling across intact muscle tissue.
Jer‐En Hsu, Lloyd Ruiz, Yongha Hwang, Steve D. Guzman, Chun‐Seok Cho, Weiqiu Cheng, Yichen Si, Peter Macpherson, Angelo Anacleto, Qingyang Zhao, Xiaoya Zhao, Mitchell Schrank, Goo Jun, Hyun Min Kang, Myungjin Kim, Susan V. Brooks, Jun Hee Lee   +16 more
wiley   +1 more source