Results 51 to 60 of about 5,582 (218)
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Expression of wildtype and Secc mutant γ-crystallins. [PDF]
, 2016 (A) P21 lenses were analyzed by western blotting with antibodies against total γ-crystallins and β-actin. The expression of γ-crystallins reduced significantly in Secc mutant lenses.
Sze Lan Tsang (370897) +7 more
core +1 more source
Annals of Neurology, EarlyView.Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens +9 more
wiley +1 more source
Decreased heat stability and increased chaperone requirement of modified human βB1-crystallins [PDF]
, 2002 Purpose: To determine how deamidation and partial loss of the N- and C-terminal extensions alter the heat stability of βB1-crystallin. Methods: Human lens βB1, a deamidated βB1, Q204E, and αA-crystallins were expressed.
Yung H Kim (20190102) +8 more
core
Crystallins are regulated biomarkers for monitoring topical therapy of glaucomatous optic neuropathy. [PDF]
PLoS ONE, 2013 Optic nerve atrophy caused by abnormal intraocular pressure (IOP) remains the most common cause of irreversible loss of vision worldwide. The aim of this study was to determine whether topically applied IOP-lowering eye drugs affect retinal ganglion ...
Verena Prokosch +2 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li +4 more
wiley +1 more source
Structure of the crystallins [PDF]
Eye, 1999 The lens is formed from two protein superfamilies, the alpha- and beta gamma-crystallins. Representative three-dimensional structures show they both have a basic 2-beta-sheet domain fold, with the beta gamma-domain being made from two intercalating Greek keys.
C, Slingsby, N J, Clout
openaire +2 more sources
Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics
Materials, 2022 Radiopacity is sometimes an essential characteristic of biomaterials that can help clinicians perform follow-ups during pre- and post-interventional radiological imaging. Due to their chemical composition and structure, most bioceramics are inherently radiopaque but can still be doped/mixed with radiopacifiers to increase their visualization during or ...
Maziar Montazerian +10 more
openaire +3 more sources
The crystallins: Genes, proteins and diseases. [PDF]
, 1997 The crystallins were discovered as the structural proteins of the vertebrate eye lens in the last century by C.T. Mörner (Z. Physiol. Chem. 18, 1893, 61-106).
Graw, J.
core
Evolution of crystallins for a role in the vertebrate eye lens [PDF]
, 2013 The camera eye lens of vertebrates is a classic example of the re-engineering of existing protein components to fashion a new device. The bulk of the lens is formed from proteins belonging to two superfamilies, the α-crystallins and the βγ-crystallins ...
Alice R. Clark +5 more
core +1 more source