Results 71 to 80 of about 18,186 (212)

CRYAB is compromised in pathologically affected oligodendrocytes in multiple system atrophy

Brain Pathology, EarlyView.
CRYAB is hypermethylated and colocalizes with α‐synuclein in multiple system atrophy oligodendrocytes.
Finula I. Isik, Jen‐Hsiang T. Hsiao, Felicia Xaveria Suteja, Shrey Shahdadpuri, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim, YuHong Fu   +7 more
wiley   +1 more source

Identification of subunit-subunit interaction sites in αA-WT crystallin and mutant αA-G98R crystallin using isotope-labeled cross-linker and mass spectrometry. [PDF]

PLoS ONE, 2013
Cataract is characterized by progressive protein aggregation and loss of vision. α-Crystallins are the major proteins in the lens responsible for maintaining transparency.
Rama Kannan, Puttur Santhoshkumar, Brian P Mooney, K Krishna Sharma   +3 more
doaj   +1 more source

A Rapid, Comprehensive Liquid Chromatography-Mass Spectrometry (LC-MS)-based Survey of the Asp Isomers in Crystallins from Human Cataract Lenses*

Journal of Biological Chemistry, 2012
Background: Asp isomers in lens crystallins are one of the triggers of cataracts. Results: Multiple highly isomeric Asp sites in insoluble crystallins from cataract lenses were identified by LC-MS using the corresponding synthetic peptides as standards ...
Norihiko Fujii, H. Sakaue, H. Sasaki, N. Fujii   +3 more
semanticscholar   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

X-ray diffraction and structure of crystallins

, 1997
The 3-dimensional organisation of crystallin polypeptides into globular proteins and their interactions into higher order structures are important factors governing optical functions related to refraction, accommodation and transparency. Single crystal X-
O.A. Bateman, B. Norledge, Bax, B., Norledge, B., D.S. Moss, B. Bax, H.P.C. Driessen, Moss, D.S., P.F. Lindley, Slingsby, C., A. Simpson, G. Wright, Bateman, O.A., Wright, G., Driessen, H.P.C., Lindley, P.F., C. Slingsby, Simpson, A.   +17 more
core   +1 more source

Research Progression of Non-lens βγ-crystallins

, 2009
In vertebrates, βγ-crystallins are mainly expressed in the lens as structural protein, a lot of non-lens βγ-crystallins were also discovered in microbes and mammals, such as Protein S and Absent in Melanoma 1, which act as microbial stress-inducible ...
Liu, Shu-bai, Qian, Jin-qiao, He, Ying-ying, Lee, Wen-hui, Zhang, Yun   +4 more
core   +1 more source

Redox Activity of the Mini-αA-crystallin–Cu(II) Complex and Its Biological Relevance

International Journal of Electrochemical Science, 2015
Cu(II) has been known to be a redox-active metal whose complexes with proteins/peptides have been linked to oxidative stress in many diseases. Oxidative stress and Cu(II) are also known to induce the expression of the small heat shock proteins α ...
Yanping Gao, Yanyan Wang, Wenxia Liu
doaj   +1 more source

OsCPN10a, cooperating with OsCPN20 and OsHSP60‐3B negatively regulate ABA signaling and enhance seed storability in rice

Journal of Integrative Plant Biology, EarlyView.
Abscisic acid signaling homeostasis is essential for seed storability. The molecular chaperone OsCPN10a enhances rice seed storability by forming a trimeric chaperone complex with OsCPN20‐OsHSP60‐3B that attenuates abscisic acid signaling via direct interaction with OsPYL10‐OsABIL1, thereby maintaining starch integrity and offering a promising target ...
Sufeng Liao, Yidong Wei, Yongsheng Zhu, Kunyang Li, Ting Chen, Shuai Zhao, Fangxi Wu, Jinlan Wang, Pengbo Yu, Hongguang Xie, Liping Chen, Qiuhua Cai, Huaan Xie, Jianfu Zhang   +13 more
wiley   +1 more source

Spatial Analysis of Single Fiber Cells of the Developing Ocular Lens Reveals Regulated Heterogeneity of Gene Expression

iScience, 2018
Summary: The developing eye lens presents an exceptional paradigm for spatial transcriptomics. It is composed of highly organized long, slender transparent fiber cells, which differentiate from the edges of the anterior epithelium of the lens (equator ...
Rajendra K. Gangalum, Dongjae Kim, Raj K. Kashyap, Serghei Mangul, Xinkai Zhou, David Elashoff, Suraj P. Bhat   +6 more
doaj   +1 more source

Ca2+ binding enhanced mechanical stability of an archaeal crystallin. [PDF]

PLoS ONE, 2014
Structural topology plays an important role in protein mechanical stability. Proteins with β-sandwich topology consisting of Greek key structural motifs, for example, I27 of muscle titin and (10)FNIII of fibronectin, are mechanically resistant as shown ...
Venkatraman Ramanujam, Hema Chandra Kotamarthi, Sri Rama Koti Ainavarapu   +2 more
doaj   +1 more source