Results 71 to 80 of about 5,582 (218)
Interaction of C-terminal truncated human alphaA-crystallins with target proteins. [PDF]
PLoS ONE, 2008 Significant portion of alphaA-crystallin in human lenses exists as C-terminal residues cleaved at residues 172, 168, and 162. Chaperone activity, determined with alcohol dehydrogenase (ADH) and betaL-crystallin as target proteins, was increased in alphaA(
Anbarasu Kumarasamy, Edathara C Abraham
doaj +1 more source
The FEBS Journal, EarlyView.Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf +7 more
wiley +1 more source
Post-Translational Modification of Crystallins in Vitreous Body from Experimental Autoimmune Uveitis of Rats [PDF]
, 2007 Experimental autoimmune uveitis (EAU) is a well-known animal model of posterior uveitis that is one of the major causes of blindness. EAU could be induced in susceptible animals (i.e., Lewis rat) by immune reactions using evolutionarily conserved retinal
Hun-Taeg Chung (583329) +8 more
core +5 more sources
Identification of subunit-subunit interaction sites in αA-WT crystallin and mutant αA-G98R crystallin using isotope-labeled cross-linker and mass spectrometry. [PDF]
PLoS ONE, 2013 Cataract is characterized by progressive protein aggregation and loss of vision. α-Crystallins are the major proteins in the lens responsible for maintaining transparency.
Rama Kannan +3 more
doaj +1 more source
Stimulating proteasomal degradation in human proteinopathies
The FEBS Journal, EarlyView.The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch +2 more
wiley +1 more source
Mass spectrometric analysis of human lens crystallins [PDF]
, 1999 The disease cataract, a major cause of blindness worldwide, is an opacification of the lens. Post-translational modifications which disrupt the close-packing of the crystallins are likely causes of the change in refractive index and the formation of ...
Hanson, Stacy Rae-Abner
core
Redox Activity of the Mini-αA-crystallin–Cu(II) Complex and Its Biological Relevance
International Journal of Electrochemical Science, 2015 Cu(II) has been known to be a redox-active metal whose complexes with proteins/peptides have been linked to oxidative stress in many diseases. Oxidative stress and Cu(II) are also known to induce the expression of the small heat shock proteins α ...
Yanping Gao, Yanyan Wang, Wenxia Liu
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Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons
Journal of Anatomy, EarlyView.To study gene expression in subpopulations of cortical subplate neurons (Lpar1‐EGFP‐positive and D1B‐positive SpN clusters), we applied gene expression profiling, including bulk microarray analysis, single‐cell RNA sequencing (scRNA‐seq), and Visium spatial transcriptomics, and identified both overlapping and unique gene expression signatures ...
Hitomi Achiwa +8 more
wiley +1 more source
iScience, 2018 Summary: The developing eye lens presents an exceptional paradigm for spatial transcriptomics. It is composed of highly organized long, slender transparent fiber cells, which differentiate from the edges of the anterior epithelium of the lens (equator ...
Rajendra K. Gangalum +6 more
doaj +1 more source
Ca2+ binding enhanced mechanical stability of an archaeal crystallin. [PDF]
PLoS ONE, 2014 Structural topology plays an important role in protein mechanical stability. Proteins with β-sandwich topology consisting of Greek key structural motifs, for example, I27 of muscle titin and (10)FNIII of fibronectin, are mechanically resistant as shown ...
Venkatraman Ramanujam +2 more
doaj +1 more source