Results 71 to 80 of about 6,105 (219)

Evolution of crystallins for a role in the vertebrate eye lens

, 2013
The camera eye lens of vertebrates is a classic example of the re-engineering of existing protein components to fashion a new device. The bulk of the lens is formed from proteins belonging to two superfamilies, the α-crystallins and the βγ-crystallins ...
Alice R. Clark, Christine Slingsby, Slingsby, Christine, Wistow, G.J., Graeme J. Wistow, Clark, Alice R.   +5 more
core   +1 more source

MALDI imaging mass spectrometry of β‐ and γ‐crystallins in the ocular lens

, 2020
Lens crystallin proteins make up 90% of expressed proteins in the ocular lens and are primarily responsible for maintaining lens transparency and establishing the gradient of refractive index necessary for proper focusing of images onto the retina.
Paul J. Donaldson, Kristie L. Rose, Anderson, David M, Kevin L. Schey, Schey, Kevin L, Angus C. Grey, Rose, Kristie L, David M. Anderson, Mitchell G. Nye‐Wood, Grey, Angus C, Nye-Wood, Mitchell G, Donaldson, Paul J   +11 more
core   +1 more source

Spatial Analysis of Single Fiber Cells of the Developing Ocular Lens Reveals Regulated Heterogeneity of Gene Expression

iScience, 2018
Summary: The developing eye lens presents an exceptional paradigm for spatial transcriptomics. It is composed of highly organized long, slender transparent fiber cells, which differentiate from the edges of the anterior epithelium of the lens (equator ...
Rajendra K. Gangalum, Dongjae Kim, Raj K. Kashyap, Serghei Mangul, Xinkai Zhou, David Elashoff, Suraj P. Bhat   +6 more
doaj   +1 more source

Molecular Chaperone Networks in Plants: Maintaining Proteostasis and Enhancing Stress Resilience for Crop Improvement

Plant, Cell &Environment, EarlyView.
ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang, Anqin Gao, Tsz‐Yan Chan, Hafiz Mamoon Rehman, Sehar Nawaz, Sehrish Bashir, Noman Mahmood, Muhammad Wajid Ullah, Chunlin Long, Hon‐Ming Lam, Muhammad Arif   +10 more
wiley   +1 more source

Development of an immunoanalytical method for the detection of β- and γ- Crystallins and anti-crystallin antibodies. A molecular biomarker for cataract

Indian Journal of Ophthalmology, 2002
Purpose: To develop and evaluate an immunoanalytical method for the detection of β - and g-crystallins and anti-crystallin antibodies. Materials and Methods: Beta and g-crystallins isolated from rat lens were used as immunogens to raise ...
Nayak Sujatha, Sashidhar R, Bhat Seetharam   +2 more
doaj  

Ca2+ binding enhanced mechanical stability of an archaeal crystallin. [PDF]

PLoS ONE, 2014
Structural topology plays an important role in protein mechanical stability. Proteins with β-sandwich topology consisting of Greek key structural motifs, for example, I27 of muscle titin and (10)FNIII of fibronectin, are mechanically resistant as shown ...
Venkatraman Ramanujam, Hema Chandra Kotamarthi, Sri Rama Koti Ainavarapu   +2 more
doaj   +1 more source

Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity

Glia, Volume 74, Issue 12, December 2026.
The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Structural integrity of the Greek key motif in βγ-crystallins is vital for central eye lens transparency. [PDF]

PLoS ONE, 2013
BACKGROUND: We highlight an unrecognized physiological role for the Greek key motif, an evolutionarily conserved super-secondary structural topology of the βγ-crystallins.
Venkata Pulla Rao Vendra, Garima Agarwal, Sushil Chandani, Venu Talla, Narayanaswamy Srinivasan, Dorairajan Balasubramanian   +5 more
doaj   +1 more source

Disulfide bond status links the open and closed conformations of prothrombin

Protein Science, Volume 35, Issue 12, December 2026.
Abstract Emerging evidence indicates that structural changes in proteins can influence autoimmune recognition. Antibodies targeting the central blood coagulation protein, prothrombin, are frequently detected in patients with the autoimmune disorder, antiphospholipid syndrome.
Mark Schreuder, Diego Butera, Suresh Kumar, Nicola Pozzi, Philip J. Hogg   +4 more
wiley   +1 more source

A novel non-lens betagamma-crystallin and trefoil factor complex from amphibian skin and its functional implications. [PDF]

PLoS ONE, 2008
In vertebrates, non-lens betagamma-crystallins are widely expressed in various tissues, but their functions are unknown. The molecular mechanisms of trefoil factors, initiators of mucosal healing and being greatly involved in tumorigenesis, have remained
Shu-Bai Liu, Ying-Ying He, Yun Zhang, Wen-Hui Lee, Jin-Qiao Qian, Ren Lai, Yang Jin   +6 more
doaj   +1 more source