Results 91 to 100 of about 8,792 (226)
Genetic Diagnosis and Discovery Enabled by Large Language Models
Advanced Science, Volume 13, Issue 22, 17 April 2026.We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu +25 more
wiley +1 more source
Anti-chaperone [eszett]A3/A1102-117 peptide interacting sites in human aB-crystallin [PDF]
, 2008 Purpose: Our previous work identified 23 low molecular weight (
Rao, Guruprasad +2 more
core
Development of cataract caused by diabetes mellitus: Raman study [PDF]
, 2004 Diabetes mellitus succeeded by diabetic cataract was induced to experimental animals (Wistar rats) by applying an Alloxan injection. Eye properties deterioration were monitored from clinical standpoint and using Raman and infrared spectroscopies.
Furić, Krešimir +2 more
core +1 more source
Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu +10 more
wiley +1 more source
Human Aldehyde Dehydrogenase 3A1 (ALDH3A1) Exhibits Chaperone-Like Function [PDF]
, 2017 Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (e.g., corneal epithelium), express
Franco, Rodrigo +5 more
core +1 more source
Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis
Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang +3 more
wiley +1 more source
Post-translationally modified human lens crystallin fragments show aggregation in vitro
Biochemistry and Biophysics Reports, 2017 Background: Crystallin fragments are known to aggregate and cross-link that lead to cataract development. This study has been focused on determination of post-translational modifications (PTMs) of human lens crystallin fragments, and their aggregation ...
O.P. Srivastava +3 more
doaj +1 more source
Age-related changes in local water and protein content of human eye lenses measured by Raman microspectroscopy [PDF]
, 1991 The Raman microspectroscopic method was used to determine the local water and protein content in human lenses. In 18 lenses of varying age position-defined water/protein content measurements were carried out along the visual and the equatorial axis.\ud ...
Greve, J. +3 more
core +3 more sources
A 17‐year‐old male with chronic epilepsy status post remote functional hemispherectomy
Brain Pathology, Volume 36, Issue 3, May 2026.
Claire Voyles +3 more
wiley +1 more source