Results 91 to 100 of about 6,105 (219)
Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype
Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9809-9818, November 2026.ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley +1 more source
Nature ChemistryAbstract The synthesis of heteronuclear alkyne analogs incorporating heavier group 14 elements (R1−C≡E−R2, E = Si, Ge, Sn, Pb) has posed a longstanding challenge, with no previous reports on isolable compounds of this nature. Until now, neutral silynes (R1−C≡Si(L)−R2) and germynes (R1−C≡Ge(L)−R2) stabilized by a Lewis base have achieved ...
Liu Leo Liu +5 more
openaire +2 more sources
The percentage of secondary structure content of different αB-crystallins obtained by FTIR analysis.
, 2021 The percentage of secondary structure content of different αB-crystallins obtained by FTIR analysis.
Reza Yousefi (3125688) +7 more
core +1 more source
Physiological expression of lens α-, β-, and γ-crystallins in murine and human corneas
, 2020 Purpose: How corneal transparency is formed/maintained remains largely unclear. A group of enzymes which are referred to as enzymatic crystallins were proposed to contribute to corneal transparency in various animals.
Changkai Jia +4 more
core
Post-translationally modified human lens crystallin fragments show aggregation in vitro
Biochemistry and Biophysics Reports, 2017 Background: Crystallin fragments are known to aggregate and cross-link that lead to cataract development. This study has been focused on determination of post-translational modifications (PTMs) of human lens crystallin fragments, and their aggregation ...
O.P. Srivastava +3 more
doaj +1 more source
The crystallins: Genes, proteins and diseases.
, 1997 The crystallins were discovered as the structural proteins of the vertebrate eye lens in the last century by C.T. Mörner (Z. Physiol. Chem. 18, 1893, 61-106).
Graw, J.
core
In vivo substrates of the lens molecular chaperones αA-crystallin and αB-crystallin.
PLoS ONE, 2014 αA-crystallin and αB-crystallin are members of the small heat shock protein family and function as molecular chaperones and major lens structural proteins.
Usha P Andley +2 more
doaj +1 more source
Evolutionary and functional relationships between the basic and acidic β-crystallins
, 1988 β-Crystallins are complex oligomers composed of many related subunits. In order to understand their interactions we have built molecular models of several bovine β-crystallins, based on their sequence similarity to the well-defined γ-II crystallin ...
Slingsby, C. +4 more
core +1 more source
Elucidating the mechanism of anti-apoptotic activity of α-crystallin and its therapeutic potential [PDF]
Journal of Stress Physiology & Biochemistryα- Crystallins are the structural proteins of the eye lens which possess anti-apoptotic activity. Both αA- and αB- crystallins are distinct antiapoptotic regulators which can interact with Bax and Bcl-XS, proapoptotic members of the Bcl-2 family in order
Aparajita Chakraborty +2 more
doaj
Mass spectrometric analysis of human lens crystallins
, 1999 The disease cataract, a major cause of blindness worldwide, is an opacification of the lens. Post-translational modifications which disrupt the close-packing of the crystallins are likely causes of the change in refractive index and the formation of ...
Hanson, Stacy Rae-Abner
core