Results 81 to 90 of about 18,186 (212)
ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang +10 more
wiley +1 more source
Structural integrity of the Greek key motif in βγ-crystallins is vital for central eye lens transparency. [PDF]
BACKGROUND: We highlight an unrecognized physiological role for the Greek key motif, an evolutionarily conserved super-secondary structural topology of the βγ-crystallins.
Venkata Pulla Rao Vendra +5 more
doaj +1 more source
ABSTRACT Understanding Neotropical megadiversity remains challenging due to fundamental taxonomic issues, including identifying and describing cryptic species and their distribution, and the limited knowledge of key factors driving biological diversification. Such challenges are especially prominent in diverse clades with high levels of cryptic species,
Felipe Camurugi +10 more
wiley +1 more source
Purpose: To develop and evaluate an immunoanalytical method for the detection of β - and g-crystallins and anti-crystallin antibodies. Materials and Methods: Beta and g-crystallins isolated from rat lens were used as immunogens to raise ...
Nayak Sujatha +2 more
doaj
A novel non-lens betagamma-crystallin and trefoil factor complex from amphibian skin and its functional implications. [PDF]
In vertebrates, non-lens betagamma-crystallins are widely expressed in various tissues, but their functions are unknown. The molecular mechanisms of trefoil factors, initiators of mucosal healing and being greatly involved in tumorigenesis, have remained
Shu-Bai Liu +6 more
doaj +1 more source
Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley +1 more source
Lens crystalline were isolated and characterized from sharks of the cartilaginous fishes. Four crystallin fractions corresponding to α-,⨿H-,βL- and γ-crystallins, similar to those of mammalian crystallins, were obtained.
Chiou, S.-H., S.-H. Chiou
core +1 more source
MALDI imaging mass spectrometry of β‐ and γ‐crystallins in the ocular lens
Lens crystallin proteins make up 90% of expressed proteins in the ocular lens and are primarily responsible for maintaining lens transparency and establishing the gradient of refractive index necessary for proper focusing of images onto the retina.
Paul J. Donaldson +11 more
core +1 more source
Copper reductase activity and free radical chemistry by cataract-associated human lens γ-crystallins
Cataracts are caused by high-molecular weight aggregates of human eye lens proteins that scatter light, causing lens opacity. Metal ions have emerged as important potential players in the etiology of cataract disease, as human lens γ-crystallins are ...
Giovanni, Palomino-Vizcaino +9 more
core +1 more source
Metal‐Dependent Effects and Crowding Robustness of Pseudomonas fluorescens Esterase I
Pseudomonas fluorescens esterase I retains catalytic activity in metal‐rich and crowded environments, despite metal‐specific inhibitory effects. These findings highlight its robustness for biocatalytic applications in complex environments. Industrial biocatalysts are strongly influenced by their physicochemical environment, yet systematic studies on ...
Emmanouil Ntermanakis +6 more
wiley +1 more source

