Structural integrity of the Greek key motif in βγ-crystallins is vital for central eye lens transparency. [PDF]
PLoS ONE, 2013 BACKGROUND: We highlight an unrecognized physiological role for the Greek key motif, an evolutionarily conserved super-secondary structural topology of the βγ-crystallins.
Venkata Pulla Rao Vendra +5 more
doaj +1 more source
Detection of Diagnostic Antibodies in Immune‐Mediated Diseases: A Focus on Antigens and Technologies
ChemBioChem, Volume 27, Issue 9, 14 May 2026.This review explores autoantibody detection in immune‐mediated diseases, highlighting autoantigens including post‐translational modifications. We compared enzyme‐linked immunosorbent assay and indirect immunofluorescence with automated chemiluminescence platforms.
Silvia Bracci +5 more
wiley +1 more source
Indian Journal of Ophthalmology, 2002 Purpose: To develop and evaluate an immunoanalytical method for the detection of β - and g-crystallins and anti-crystallin antibodies. Materials and Methods: Beta and g-crystallins isolated from rat lens were used as immunogens to raise ...
Nayak Sujatha +2 more
doaj
A novel non-lens betagamma-crystallin and trefoil factor complex from amphibian skin and its functional implications. [PDF]
PLoS ONE, 2008 In vertebrates, non-lens betagamma-crystallins are widely expressed in various tissues, but their functions are unknown. The molecular mechanisms of trefoil factors, initiators of mucosal healing and being greatly involved in tumorigenesis, have remained
Shu-Bai Liu +6 more
doaj +1 more source
UV-radiation Induced Disruption of Dry-Cavities in Human γD-crystallin Results in Decreased Stability and Faster Unfolding [PDF]
, 2012 Age-onset cataracts are believed to be expedited by the accumulation of UV-damaged human γD-crystallins in the eye lens. Here we show with molecular dynamics simulations that the stability of γD-crystallin is greatly reduced by the conversion of ...
Huynh, Tien +4 more
core +2 more sources
Carbon turnover in the water-soluble protein of the adult human lens. [PDF]
, 2013 PurposeHuman eye lenses contain cells that persist from embryonic development. These unique, highly specialized fiber cells located at the core (nucleus) of the lens undergo pseudo-apoptosis to become devoid of cell nuclei and most organelles. Ostensibly
Buchholz, Bruce A +7 more
core +1 more source
Why Is MS a More Frequent Complication of EBV Infection in Females?
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn +2 more
wiley +1 more source
Exploring the Universe within the Human Lens Through Raman Spectroscopy
Delhi Journal of Ophthalmology, 2017 Ever since the emergence of refined modalities of cataract surgery, the looming question has been the same - How to improve the technique, to minimize manipulation of biological components and optimize the end result? The most recent development has been,
Praveen K Malik +3 more
doaj +1 more source
Identification of hydrophobic sites on UV irradiated beta crystallins from bovine lenses [abstract] [PDF]
, 2004 only availableFaculty Mentor: Dr. Krishna Sharma, OphthalmologyThe lens of the eye is an avascular tissue of a complex network of proteins surrounded by a capsule.
Rednam, Rukmini
core
Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
Advanced Science, Volume 13, Issue 23, 23 April 2026.This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi +13 more
wiley +1 more source