Results 101 to 110 of about 5,582 (218)

Post-translationally modified human lens crystallin fragments show aggregation in vitro

Biochemistry and Biophysics Reports, 2017
Background: Crystallin fragments are known to aggregate and cross-link that lead to cataract development. This study has been focused on determination of post-translational modifications (PTMs) of human lens crystallin fragments, and their aggregation ...
O.P. Srivastava, K. Srivastava, J.M. Chaves, A.K. Gill   +3 more
doaj   +1 more source

In vivo substrates of the lens molecular chaperones αA-crystallin and αB-crystallin.

PLoS ONE, 2014
αA-crystallin and αB-crystallin are members of the small heat shock protein family and function as molecular chaperones and major lens structural proteins.
Usha P Andley, James P Malone, R Reid Townsend   +2 more
doaj   +1 more source

Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts [PDF]

, 2003
Congenital cataracts are a major cause of bilateral visual impairment in childhood. We mapped the gene responsible for autosomal congenital cerulean cataracts to chromosome 2q33-35 in a four generation family of Moroccan descent. The maximum lod score (7.
Basak, A, Hilal, L., Cherif Chefchaouni, M., Slingsby, Christine, Hajaji, Y, Basak, Ajit K., Arbogast, L., Abitbol, Marc, M, Nandrot, E., Cherif-Chefchaouni, M, Benazzouz, B, Boutayeb, S, Boutayeb, S., Berraho, A., Hilal, Latifa, Abitbol, M., Arbogast, Laurence, Hajaji, Y., Gribouval, O., Benazzouz, B., Abitbol, Marc,, Nandrot, Emeline, Gribouval, Olivier   +22 more
core   +1 more source

Elucidating the mechanism of anti-apoptotic activity of α-crystallin and its therapeutic potential [PDF]

Journal of Stress Physiology & Biochemistry
α- Crystallins are the structural proteins of the eye lens which possess anti-apoptotic activity. Both αA- and αB- crystallins are distinct antiapoptotic regulators which can interact with Bax and Bcl-XS, proapoptotic members of the Bcl-2 family in order
Aparajita Chakraborty, Priyanka De, Sudipa Saha   +2 more
doaj  

Alpha‐B‐crystallin immunohistochemistry: A sensitive but non‐specific marker for epileptogenic lesions

Brain Pathology, Volume 36, Issue 5, September 2026.
Ekin Güney, Ilay Caliskan, Tara Saunders, Mercedes Paredes, Calixto‐Hope Lucas, Kanish Mirchia, Rufei Lu, Merryl Terry, Erika Cagampan, Melike Pekmezci, Andrew Bollen, Arie Perry, Cathryn R. Cadwell, Tarık Tihan   +13 more
wiley   +1 more source

Aggregation of βγ-crystallins [PDF]

, 2022
Proteini so biološki linearni heteropolimeri, sestavljeni iz 20 različnih tipov monomerov, ki jih imenujemo aminokisline. So v naravi najbolj zastopane biološke makromolekule z zelo širokim naborom funkcij in obratovalnih okolij.
Dobrovoljc, Vid
core  

Susceptibility of Ovine Lens Crystallins to Proteolytic Cleavage during Formation of Hereditary Cataract [PDF]

, 2008
PURPOSE. To produce two-dimensional electrophoresis (2-DE) maps for ovine crystallins and examine changes in ovine crystallins during cataract formation. METHODS.
Michael A Riviere, James D Morton, Phillip A Wilmarth, Larry L David, Matthew S Muir, Lucinda J G Robertson   +5 more
core  

A Crystalline In(II) Hydride [PDF]

Journal of the American Chemical Society
Subvalent hydride species of heavier main-group elements are notoriously elusive due to their intrinsic instability and rapid decomposition, generating hydrogen. Nevertheless, they offer significant potential for small-molecule activation and catalysis.
Olympia Mouriki, Graham J. Tizzard, Simon J. Coles, Diego M. Andrada, Oriol Planas   +4 more
openaire   +3 more sources

Association of partially folded lens beta B2-crystallins with the alpha-crystallin molecular chaperone [PDF]

, 2007
Age-related cataract is a result of crystallins, the predominant lens proteins, forming light-scattering aggregates. In the low protein turnover environment of the eye lens, the crystallins are susceptible to modifications that can reduce stability ...
Evans, P., Wallace, Bonnie A., Slingsby, Christine, Wallace, B A, Evans, Paul   +4 more
core   +1 more source

An Exploration of Human D-Crystallin Affinity for Potential Aggregation Inhibitors: A Molecular Docking Investigation

Studia Universitatis Babes-Bolyai Chemia
Cataract, the leading cause of blindness worldwide, is characterized by the presence of a cloudy area in the eye lens resulting in a loss of transparency.
Călin G. FLOARE, Adrian PÎRNĂU, Mihaela MIC, Elena MATEI   +3 more
doaj   +1 more source