Elucidating the mechanism of anti-apoptotic activity of α-crystallin and its therapeutic potential [PDF]
Journal of Stress Physiology & Biochemistryα- Crystallins are the structural proteins of the eye lens which possess anti-apoptotic activity. Both αA- and αB- crystallins are distinct antiapoptotic regulators which can interact with Bax and Bcl-XS, proapoptotic members of the Bcl-2 family in order
Aparajita Chakraborty +2 more
doaj
Association of High Myopia with Crystallin Beta A4 (CRYBA4) Gene Polymorphisms in the Linkage-Identified MYP6 Locus [PDF]
, 2012 Background: Myopia is the most common ocular disorder worldwide and imposes tremendous burden on the society. It is a complex disease. The MYP6 locus at 22 q12 is of particular interest because many studies have detected linkage signals at this interval.
Fung, WY +4 more
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Studia Universitatis Babes-Bolyai ChemiaCataract, the leading cause of blindness worldwide, is characterized by the presence of a cloudy area in the eye lens resulting in a loss of transparency.
Călin G. FLOARE +3 more
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A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues
Redox Biology, 2015 Excessive ultraviolet radiation (UVR) exposure of the skin is associated with adverse clinical outcomes. Although both exogenous sunscreens and endogenous tissue components (including melanins and tryptophan-derived compounds) reduce UVR penetration, the
Sarah A. Hibbert +7 more
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Crystalline and Non-crystalline Solids [PDF]
, 2016 The structural properties of materials play a fundamental role in the determination of their suitability for a specific application. This book is intended as a contribution to the efforts to increase the knowledge of the influence exerted on the properties of materials by their crystalline or amorphous structure. To this aim, some of the materials that
openaire +3 more sources
Development of ex vivo organ culture models to mimic human corneal scarring [PDF]
, 2012 PURPOSE: To develop ex vivo organ culture models of human corneal scarring suitable for pharmacological testing and the study of the molecular mechanisms leading to corneal haze after laser surgery or wounding.
Damour, O +6 more
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A novel fan-shaped cataract-microcornea syndrome caused by a mutation of CRYAA in an Indian family [PDF]
, 2006 PURPOSE: The molecular characterization of an Indian family having 10 members in four generations affected with a unique fan-shaped cataract-microcornea syndrome. METHODS: Detailed family history and clinical data were recorded.
Hejtmancik, J.F. +6 more
core
A Fiber Optic Probe for the Detection of Cataracts [PDF]
, 1993 A compact fiber optic probe developed for on-orbit science experiments was used to detect the onset of cataracts, a capability that could eliminate physicians' guesswork and result in new drugs to 'dissolve' or slow down the cataract formation before ...
Ansari, Rafat R., Dhadwal, Harbans S.
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Protein refractive index increment is determined by conformation as well as composition. [PDF]
, 2018 The refractive index gradient of the eye lens is controlled by the concentration and distribution of its component crystallin proteins, which are highly enriched in polarizable amino acids.
Bierma, Jan C +4 more
core
Aging cellular networks: chaperones as major participants
, 2006 We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which have among their functions to sequester and repair damaged protein. In order to link the network
Agoston +56 more
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