Results 121 to 130 of about 18,186 (212)

Sequence comparison of γ-crystallins from the reptilian and other vertebrate species

, 1987
Lens crystalline were isolated from homogenates of reptilian eye lenses (Caiman crocodylus apaporiensis) by gel-permeation chromatography and characterized by gel electrophoresis, and amino acid and N-terminal sequence analyses.
Chen, S.-W., W.-P. Chang, Chang, W.-P., S.-W. Chen, Lo, C.-H., C.-H. Lo, Chiou, S.-H., S.-H. Chiou   +7 more
core   +1 more source

Micropurification of beta- and gamma- crystallins from rabbit aqueous humor.

, 1999
Soluble crystallins are normally present in the aqueous humor, originating from the lens, and their concentration may increase in certain conditions such as cataract, possibly contributing to aqueous outflow pathway obstruction, leading to glaucoma ...
LEONE M. G., SASO, Luciano, CHENG C. Y., SILVESTRINI, Bruno   +3 more
core  

Phylogenetic comparison of lens crystallins from the vertebrate and invertebrate - convergent or divergent evolution?

, 1986
A systematic biochemical comparison has been made of the crystallins isolated from the lenses of five different species belonging to the five major classes of vertebrates.
Chiou, Shyh-Horng, Shyh-Horng Chiou
core   +1 more source

Copper Reductase Activity and Free Radical Chemistry by Cataract-Associated Human Lens γ‑Crystallins

Cataracts are caused by high-molecular-weight aggregates of human eye lens proteins that scatter light, causing lens opacity. Metal ions have emerged as important potential players in the etiology of cataract disease, as human lens γ-crystallins are ...
Giovanni Palomino-Vizcaino (6888008), Nils Schuth (3109095), Eduardo Martínez-Jurado (14792120), Oscar Rodríguez-Meza (14792117), Liliana Quintanar (1433170), Thomas Kroll (1348488), Jonathan A. King (321731), Miguel Costas (74685), Eugene Serebryany (1433164), José A. Domínguez-Calva (14792114)   +9 more
core   +1 more source

Porcine eye lens crystallins: Antigenic similarity with human crystallins and tool for the detection of anti-crystallin antibodies

, 2002
Background: The usual sources of antigenic material for investigations on circulating immunoglobulins with anti-lens crystallins specificity are saline extracts of human cataract lenses.
Breipohl, Winrich, Trifonova, Radiana, Kalaydjiev, Svetoslav, Trifonova, Nedka, Stamenova, Maria   +4 more
core   +1 more source

Modifications of human βA1/βA3-crystallins include S-methylation, glutathiolation, and truncation

, 2005
Disulfide bonding of lens crystallins contributes to the aggregation and insolubilization of these proteins that leads to cataract. A high concentration of reduced glutathione is believed to be key in preventing oxidation of crystallin sulfhydryls to ...
Cerny, Ronald, Jean B. Smith, Smith, Jean B., Veniamin N. Lapko, David L. Smith, Smith, David L., Lapko, Veniamin N., Ronald L. Cerny   +7 more
core   +1 more source

Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts

, 2003
Congenital cataracts are a major cause of bilateral visual impairment in childhood. We mapped the gene responsible for autosomal congenital cerulean cataracts to chromosome 2q33-35 in a four generation family of Moroccan descent. The maximum lod score (7.
Basak, A, Hilal, L., Cherif Chefchaouni, M., Slingsby, Christine, Hajaji, Y, Basak, Ajit K., Arbogast, L., Abitbol, Marc, M, Nandrot, E., Cherif-Chefchaouni, M, Benazzouz, B, Boutayeb, S, Boutayeb, S., Berraho, A., Hilal, Latifa, Abitbol, M., Arbogast, Laurence, Hajaji, Y., Gribouval, O., Benazzouz, B., Abitbol, Marc,, Nandrot, Emeline, Gribouval, Olivier   +22 more
core   +1 more source

Aggregation of βγ-crystallins

, 2022
Proteini so biološki linearni heteropolimeri, sestavljeni iz 20 različnih tipov monomerov, ki jih imenujemo aminokisline. So v naravi najbolj zastopane biološke makromolekule z zelo širokim naborom funkcij in obratovalnih okolij.
Dobrovoljc, Vid
core  

Susceptibility of Ovine Lens Crystallins to Proteolytic Cleavage during Formation of Hereditary Cataract

, 2008
PURPOSE. To produce two-dimensional electrophoresis (2-DE) maps for ovine crystallins and examine changes in ovine crystallins during cataract formation. METHODS.
Michael A Riviere, James D Morton, Phillip A Wilmarth, Larry L David, Matthew S Muir, Lucinda J G Robertson   +5 more
core  

Association of partially folded lens beta B2-crystallins with the alpha-crystallin molecular chaperone

, 2007
Age-related cataract is a result of crystallins, the predominant lens proteins, forming light-scattering aggregates. In the low protein turnover environment of the eye lens, the crystallins are susceptible to modifications that can reduce stability ...
Evans, P., Wallace, Bonnie A., Slingsby, Christine, Wallace, B A, Evans, Paul   +4 more
core   +1 more source