Results 61 to 70 of about 18,186 (212)

Functional Role of γ-Crystallin N in the Auditory Hindbrain. [PDF]

PLoS ONE, 2016
γ-crystallins are major components of the vertebrate lens but show expression in other tissues as well. Their extralenticular functions remain so far unclear.
Heiner Hartwich, Elena Rosengauer, Lukas Rüttiger, Viviane Wilms, Sarah-Kristin Waterholter, Hans Gerd Nothwang   +5 more
doaj   +1 more source

Verknüpfung der synthetischen Materialchemie mit elektrokatalytischer Leistungsfähigkeit

Angewandte Chemie, EarlyView.
Die synthetische Materialchemie bestimmt die Leistung von Elektrokatalysatoren durch eine präzise Kontrolle von Phase, Zusammensetzung, Defekten und Morphologie, während neuartige operando‐gestützte Methoden, datengetriebene Ansätze und automatisierte Labore das Fachgebiet in Richtung einer prädiktiven Katalysatorentwicklung für nachhaltige ...
Debabrata Bagchi, J. Niklas Hausmann, Tobias Sontheimer, Prashanth W. Menezes   +3 more
wiley   +1 more source

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li, Xue Wang, Wei Du, Qian Li, Hong‐Ping Cui   +4 more
wiley   +1 more source

The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function [PDF]

PeerJ, 2017
Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or ...
Mason Posner, Kelly L. Murray, Matthew S. McDonald, Hayden Eighinger, Brandon Andrew, Amy Drossman, Zachary Haley, Justin Nussbaum, Larry L. David, Kirsten J. Lampi   +9 more
doaj   +2 more sources

Aldehyde dehydrogenases: From eye crystallins to metabolic disease and cancer stem cells

Chemico-Biological Interactions, 2012
The aldehyde dehydrogenase (ALDH) superfamily is composed of nicotinamide adenine dinucleotide (phosphate) (NAD(P)+)-dependent enzymes that catalyze the oxidation of aldehydes to their corresponding carboxylic acids.
V. Vasiliou, D. Thompson, Clay Smith, M. Fujita, Ying Chen   +4 more
semanticscholar   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.

PLoS ONE, 2018
The mammalian eye lens expresses a high concentration of crystallins (α, β and γ-crystallins) to maintain the refractive index essential for lens transparency. Crystallins are long-lived proteins that do not turnover throughout life.
Usha P Andley, Eric Tycksen, Brittney N McGlasson-Naumann, Paul D Hamilton   +3 more
doaj   +1 more source

Cataract-causing mutation S228P promotes βB1-crystallin aggregation and degradation by separating two interacting loops in C-terminal domain

Protein & Cell, 2016
β/γ-Crystallins are predominant structural proteins in the cytoplasm of lens fiber cells and share a similar fold composing of four Greek-key motifs divided into two domains.
Liang-Bo Qi, Li-Dan Hu, Huihui Liu, Hai-Yun Li, Xiao-Yao Leng, Yong-Bin Yan   +5 more
doaj   +1 more source

Lens crystallins and oxidation: the special case of γS

, 2001
International audienceAmong lens crystallins, gamma -crystallins are particularly sensitive to oxidation, because of their high amount of Cys and Met residues.
Nicolette H. Lubsen, Annette Tardieu, Bonneté, Françoise, Skouri-Panet, Fériel, Orval A. Bateman, Françoise Bonneté, Tardieu, Annette, Karine Prat, Prat, Karine, Fériel Skouri-Panet, Lubsen, Nicolette, Bateman, Orval   +11 more
core   +1 more source

Interaction of C-terminal truncated human alphaA-crystallins with target proteins. [PDF]

PLoS ONE, 2008
Significant portion of alphaA-crystallin in human lenses exists as C-terminal residues cleaved at residues 172, 168, and 162. Chaperone activity, determined with alcohol dehydrogenase (ADH) and betaL-crystallin as target proteins, was increased in alphaA(
Anbarasu Kumarasamy, Edathara C Abraham
doaj   +1 more source