Results 61 to 70 of about 8,792 (226)
Acta Ophthalmologica, EarlyView.Abstract Purpose To compare the inflammatory response in the eye after trabeculectomy to after phacoemulsification, focusing on anterior chamber flare (AC flare) and central macular thickness (CMT). Methods Data from 436 participants in two randomized controlled trials were analysed.
Yasmeen Ahmed +5 more
wiley +1 more source
The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function [PDF]
PeerJ, 2017 Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or ...
Mason Posner +9 more
doaj +2 more sources
Mechanism of action of VP1-001 in cryAB(R120G)-associated and age-related cataracts [PDF]
, 2019 PurposeWe previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand the mechanism of VP1-001, we tested the ability of its enantiomer, ent-VP1-001, to bind ...
Andley, Usha P. +10 more
core +2 more sources
Protein & Cell, 2016 β/γ-Crystallins are predominant structural proteins in the cytoplasm of lens fiber cells and share a similar fold composing of four Greek-key motifs divided into two domains.
Liang-Bo Qi +5 more
doaj +1 more source
Comparison of the Lens Protein Profiles of Three Species of Ozark Salamanders [PDF]
, 1979 The vertebrate lens has a high protein content (35%), 80-90% of which is composed of the soluble, lens-specific structural proteins, the crystallins. The lens protein profiles of urodelan species have been found to be qualitatively distinct.
Britton, James M.
core +2 more sources
The FEBS Journal, EarlyView.Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf +7 more
wiley +1 more source
PLoS ONE, 2018 The mammalian eye lens expresses a high concentration of crystallins (α, β and γ-crystallins) to maintain the refractive index essential for lens transparency. Crystallins are long-lived proteins that do not turnover throughout life.
Usha P Andley +3 more
doaj +1 more source
Interaction of C-terminal truncated human alphaA-crystallins with target proteins. [PDF]
PLoS ONE, 2008 Significant portion of alphaA-crystallin in human lenses exists as C-terminal residues cleaved at residues 172, 168, and 162. Chaperone activity, determined with alcohol dehydrogenase (ADH) and betaL-crystallin as target proteins, was increased in alphaA(
Anbarasu Kumarasamy, Edathara C Abraham
doaj +1 more source
Effect of Substrate Composition and Alignment on Corneal Cell Phenotype [PDF]
, 2011 Corneal blindness is a significant problem treated primarily by corneal transplants. Donor tissue supply is low, creating a growing need for an alternative.
Phu, Donna, \u2709 +4 more
core +3 more sources
Neuroinflammation as a result of non‐neurotropic herpesvirus infection
Immunology &Cell Biology, EarlyView.Atypical memory B cells (ABCs) might stimulate autoreactive T cells to cause neuroinflammation and CNS myeloid cell activation during MS. Abstract The non‐neurotropic Epstein Barr virus (EBV) has been suggested to initiate the prodromal phase of multiple sclerosis (MS), often years before the first clinical symptoms. This review discusses mechanisms by
Christian Münz
wiley +1 more source