Results 61 to 70 of about 6,105 (219)

Genetics of crystallins: Cataract and beyond.

, 2009
The crystallins were discovered more than 100 years ago by Morner (1893. Untersuchungen der Proteinsubstanzen in den lichtbrechenden Medien des Auges. Z. Physiol. Chem. 18, 61-106) as the main structural proteins of the vertebrate eye lens.
Graw, J.
core   +1 more source

Brief encounters and lasting impressions—How target protein half‐life affects reactive metabolite signaling

The FEBS Journal, EarlyView.
Lipid‐derived reactive electrophile molecules (REMs) are generated from fatty acids through lipoxygenase or cyclooxygenase‐assisted catalysis, or free radical‐induced lipid peroxidation events. REMs so‐produced covalently modify nearby protein‐cysteines, and in the case of ‘first responder’ proteins, can trigger gain‐of‐function signaling with context ...
Marcus J. C. Long, Lorna Birkby, Yimon Aye   +2 more
wiley   +1 more source

Crystalline Chlorocruorin [PDF]

Nature, 1933
Abstract Chlorocruorin is a respiratory pigment, closely allied to hæmoglobin, which occurs only in the blood of certain polychæte worms (Fox, 1926, 1932, 1933). We have now succeeded in crystallizing chlorocruorin. A description is given below of the method of crystallization, of the nature of the crystals, of the absorption spectrum
Jean Roche, Harold Munro Fox
openaire   +2 more sources

X-ray diffraction and structure of crystallins

, 1997
The 3-dimensional organisation of crystallin polypeptides into globular proteins and their interactions into higher order structures are important factors governing optical functions related to refraction, accommodation and transparency. Single crystal X-
O.A. Bateman, B. Norledge, Bax, B., Norledge, B., D.S. Moss, B. Bax, H.P.C. Driessen, Moss, D.S., P.F. Lindley, Slingsby, C., A. Simpson, G. Wright, Bateman, O.A., Wright, G., Driessen, H.P.C., Lindley, P.F., C. Slingsby, Simpson, A.   +17 more
core   +1 more source

Interaction of C-terminal truncated human alphaA-crystallins with target proteins. [PDF]

PLoS ONE, 2008
Significant portion of alphaA-crystallin in human lenses exists as C-terminal residues cleaved at residues 172, 168, and 162. Chaperone activity, determined with alcohol dehydrogenase (ADH) and betaL-crystallin as target proteins, was increased in alphaA(
Anbarasu Kumarasamy, Edathara C Abraham
doaj   +1 more source

Eye lens stable isotope analysis reveals potential discharge‐related changes in habitat use by Blue Sucker (Cycleptus elongatus)

Journal of Fish Biology, EarlyView.
Abstract Stable isotope analysis (SIA) of eye lenses can provide a retrospective view of resource use over a fish's life. This tool can be valuable for studying long‐term isotopic changes in non‐game species that typically receive limited research emphasis.
Benjamin J. Schall, Steven. R. Chipps
wiley   +1 more source

Metal Oxides Catalyze Formation of Dehydroamino Acids by Phosphate β‐Elimination Under Physiological Conditions

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Dehydroamino acids (DHAA) are atypical electrophilic sites that lead to crosslinked proteins in Alzheimer's disease (AD) brains. No catalyst for their formation has been known in humans. We report that metal oxides catalyze β‐elimination of phosphoserine and phosphothreonine in model peptides at pH 7.5°C and 37°C, yielding DHAAs.
Samuel W. Markovich, Brian L. Frey, Mark Scalf, Lloyd M. Smith   +3 more
wiley   +2 more sources

Redox Activity of the Mini-αA-crystallin–Cu(II) Complex and Its Biological Relevance

International Journal of Electrochemical Science, 2015
Cu(II) has been known to be a redox-active metal whose complexes with proteins/peptides have been linked to oxidative stress in many diseases. Oxidative stress and Cu(II) are also known to induce the expression of the small heat shock proteins α ...
Yanping Gao, Yanyan Wang, Wenxia Liu
doaj   +1 more source

Identification of subunit-subunit interaction sites in αA-WT crystallin and mutant αA-G98R crystallin using isotope-labeled cross-linker and mass spectrometry. [PDF]

PLoS ONE, 2013
Cataract is characterized by progressive protein aggregation and loss of vision. α-Crystallins are the major proteins in the lens responsible for maintaining transparency.
Rama Kannan, Puttur Santhoshkumar, Brian P Mooney, K Krishna Sharma   +3 more
doaj   +1 more source

Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons

Journal of Anatomy, EarlyView.
To study gene expression in subpopulations of cortical subplate neurons (Lpar1‐EGFP‐positive and D1B‐positive SpN clusters), we applied gene expression profiling, including bulk microarray analysis, single‐cell RNA sequencing (scRNA‐seq), and Visium spatial transcriptomics, and identified both overlapping and unique gene expression signatures ...
Hitomi Achiwa, Yuichiro Hara, Hideya Kawaji, Minori Oshima, Noe Kaneko, Ayumu Morioka, Anna Hoerder‐Suabedissen, Zoltán Molnár, Chiaki Ohtaka‐Maruyama   +8 more
wiley   +1 more source