Results 41 to 50 of about 354,799 (167)

Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.

PLoS ONE, 2008
BackgroundThe Ca(v)beta subunits of high voltage-activated Ca(2+) channels control the trafficking and biophysical properties of the alpha(1) subunit. The Ca(v)beta-alpha(1) interaction site has been mapped by crystallographic studies.
Iuliia Vitko, Aleksandr Shcheglovitov, Joel P Baumgart, Imilla I Arias-Olguín, Janet Murbartián, Juan Manuel Arias, Edward Perez-Reyes   +6 more
doaj   +1 more source

Nitrogen recycling by the gut microbiome in sarcopenia

Frontiers in Microbiology
IntroductionSarcopenia, which is defined as loss of skeletal muscle mass and strength, affects up to 70% of patients with liver cirrhosis. Since hibernating animals maintain muscle mass through microbial nitrogen recycling, urease-producing bacteria may ...
Rosa Haller, Rosa Haller, Olha Hazia, Olha Hazia, Nicole Feldbacher, Nicole Feldbacher, Julia Traub, Tobias Madl, Tobias Madl, Hansjörg Habisch, Angela Horvath, Angela Horvath, Vanessa Stadlbauer, Vanessa Stadlbauer, Vanessa Stadlbauer   +14 more
doaj   +1 more source

Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS.

PLoS ONE, 2015
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons. The mechanisms leading to motor neuron degeneration in ALS are unclear.
Fernando G Vieira, Qinggong Ping, Andy J Moreno, Joshua D Kidd, Kenneth Thompson, Bingbing Jiang, John M Lincecum, Monica Z Wang, Gerard S De Zutter, Valerie R Tassinari, Beth Levine, Theo Hatzipetros, Alan Gill, Steven Perrin   +13 more
doaj   +1 more source

Biochemical characterization of the GM2 gangliosidosis B1 variant

Brazilian Journal of Medical and Biological Research, 2004
The deficiency of the A isoenzyme of ß-hexosaminidase (Hex) produced by different mutations of the gene that codes for the alpha subunit (Tay-Sachs disease) has two variants with enzymological differences: the B variant consists of the absence of Hex A ...
J.C. Tutor
doaj   +1 more source

Caste-based differential transcriptional expression of hexamerins in response to a juvenile hormone analog in the red imported fire ant (Solenopsis invicta).

PLoS ONE, 2019
The reproductive ground plan hypothesis proposes that gene networks regulating foraging behavior and reproductive female physiology in social insects emerged from ancestral gene and endocrine factor networks.
Chloe Hawkings, Travis L Calkins, Patricia V Pietrantonio, Cecilia Tamborindeguy   +3 more
doaj   +1 more source

Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice

Molecular Brain, 2019
Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins.
Hye Lim Cha, Jung-Mi Choi, Huy-Hyen Oh, Narayan Bashyal, Sung-Soo Kim, Lutz Birnbaumer, Haeyoung Suh-Kim   +6 more
doaj   +1 more source

Hop-on hop-off: importin-a-guided tours to the nucleus in innate immune signaling

Frontiers in Plant Science, 2013
Nuclear translocation of immune regulatory proteins and signal transducers is an essential process in animal and plant defense signaling against pathogenic microbes.
Lennart eWirthmueller, Charlotte eRoth, Mark J. Banfield, Marcel eWiermer   +3 more
doaj   +1 more source

Complementation of the interferon alpha response in resistant cells by expression of the cloned subunit of the interferon alpha receptor. A central role of this subunit in interferon alpha signaling

Journal of Biological Chemistry, 1994
A subunit of the interferon alpha receptor (IFN alpha R) that confers biologic response to and specific "binding" for IFN alpha 8 has recently been cloned. We have explored the biological consequences of expressing the cloned IFN alpha R subunit in human cells resistant to IFN alpha and in mouse cell lines nonresponsive to human IFN alpha.
O R, Colamonici, B, Porterfield, P, Domanski, S, Constantinescu, L M, Pfeffer   +4 more
openaire   +2 more sources

Analysis of Migration and Adaptive Evolution in Tibetan Sheep Populations

Animals
The genetic basis for Tibetan sheep adaptation to different high-altitude environments remains unknown. This study conducted whole-genome resequencing on 80 Tibetan sheep individuals from four major distribution areas on the Qinghai–Tibet Plateau.
Wentao Zhang, Chao Yuan, Tingting Guo, Bowen Chen, Fan Wang, Jianbin Liu, Zengkui Lu   +6 more
doaj   +1 more source

The haemoglobin subunits alpha and beta: Old and new genetic variants in the Italian Mediterranean buffalo

Czech Journal of Animal Science, 2019
Haemoglobin (HB), the most widely distributed respiratory pigment in the animal kingdom, is among the best characterized oxygen-binding proteins, both at functional and molecular level.
Rosario Rullo, Aldo Di Luccia, Elena Ciani, Elisa Pieragostini   +3 more
doaj   +1 more source