Results 51 to 60 of about 33,359,923 (277)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

An Enhanced Photothermal Therapeutic Iridium Hybrid Platform Reversing the Tumor Hypoxic Microenvironment

Molecules, 2022
As hypoxia is closely associated with tumor progression, proliferation, invasion, metastasis, and strong resistance to therapy, regulating and overcoming the hypoxia tumor microenvironment are two increasingly important aspects of tumor treatment. Herein,
Hang Zhang, Xiaoxiao Chen, Shengliang Li, Jianliang Shen, Zong-Wan Mao   +4 more
doaj   +1 more source

MOESM1 of The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis

, 2019
Additional file 1: Table S1. Quality score assessment. Table S2. Sensitivity analyses for rs2057482 polymorphism and cancer susceptibility. Table S3. Sensitivity analyses for rs2057482 polymorphism and cancer susceptibility in Asian population. Table S4. MAFs of rs2057482 polymorphism in the populations from the 1000 Genomes Project Phase 3.
Wu, Li-Fang, Xu, Gui-Ping, Zhao, Qing, Zhou, Li-Jing, Wang, Ding, Chen, Wei-Xian   +5 more
openaire   +1 more source

A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery [PDF]

, 2008
Background: Several human pathologies, including neoplasia and ischemic cardiovascular diseases, course with an unbalance between oxygen supply and demand ( hypoxia).
Alcaide-German, ML, Del Peso, L, Garcia-Fernandez, LF, Vara-Vega, A, Landazuri, MO   +4 more
core  

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium [PDF]

, 2013
Background: While acute lung injury (ALI) contributes significantly to critical illness, it resolves spontaneously in many instances. The majority of patients experiencing ALI require mechanical ventilation.
Christoph H Borchers, Michel Mittelbronn, Thomas Packard, Kominsky, Douglas J., Bonney, Megan, Packard, Thomas, Michel Mittelbronn (307400), Eltzschig, Holger K., Holger K Eltzschig, Kelley Brodsky (448211), Mariani, Thomas J., Borchers, Christoph H., Brodsky, Kelley, Christoph H. Borchers (159697), Thomas J. Mariani (11667), Han, Jun, Eckle, Tobias, Holger K. Eltzschig (37610), Mittelbronn, Michel Guy André, Megan Bonney (462424), Thomas J Mariani, Jun Han, Douglas J Kominsky, Douglas J. Kominsky (462426), Tobias Eckle, Jun Han (231645), Kelley Brodsky, Megan Bonney, Tobias Eckle (65757), Thomas Packard (462425)   +29 more
core   +1 more source

Contribution of hypoxia inducible factor-1 during viral infections

Virulence, 2020
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs ...
Antonia Reyes, Nicolás Corrales, Nicolás M. S. Gálvez, Susan M. Bueno, Alexis M. Kalergis, Pablo A. González   +5 more
doaj   +1 more source

Molecular Characterization and Functional Analysis of Hypoxia-Responsive Factor Prolyl Hydroxylase Domain 2 in Mandarin Fish (Siniperca chuatsi)

Animals, 2023
With increased breeding density, the phenomenon of hypoxia gradually increases in aquaculture. Hypoxia is primarily mediated by the hypoxia-inducible factor 1 (HIF-1) signaling pathway. Prolyl hydroxylase domain proteins (PHD) are cellular oxygen-sensing
Yang Yu, Jian He, Wenhui Liu, Zhimin Li, Shaoping Weng, Jianguo He, Changjun Guo   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Inherited/Genetically-Associated Pheochromocytoma/ Paraganglioma Syndromes and COVID-19

Medicina, 2021
In some subjects with inherited pheochromocytoma/paraganglioma (PPG) syndromes, hypoxia-inducible factor 1 alpha (HIF1α) stabilization/activation could lead to an increase in angiotensin converting enzymes (ACE).
Ioannis Ilias, Gregory Kaltsas, Konstantinos Barkas, George P. Chrousos   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source