Results 91 to 100 of about 136,719 (278)

Hypoxia-inducible factor-1α as a biomarker for individuals under hypoxia duration and pattern in fat greenling Hexagrammos otakii

Aquaculture Reports
Background: One common environmental stressor in fisheries is hypoxia stress, which frequently causes significant fish mortality and financial losses. This study aimed to examine the potential utility of serum concentrations of hypoxia-inducible factor ...
Yu Zhan, Xin Qi, Yiting Wu, Dongxu Gao, Ling Zhao, Shengnan Cao, Zhuang Xue, Wei Wang   +7 more
doaj   +1 more source

Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

Molecular Neurodegeneration, 2010
Background Mutations in presenilin-1 (Psen1) cause familial Alzheimer's disease (FAD). Both hypoxia and ischemia have been implicated in the pathological cascade that leads to amyloid deposition in AD.
Sosa Miguel, De Gasperi Rita, Dracheva Stella, Elder Gregory A   +3 more
doaj   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

HIF-1α and HIF-2α expression in mouse kidney. [PDF]

, 2012
The physiological expression pattern of HIF-1α and HIF-2α was analyzed by immunohistochemistry on kidney sections of normoxic and hypoxic (6 h, 7% O2) mice.
Ruth E. Schietke (186088), Christian Rosenberger (186134), Bernd Klanke (186110), Christina L. Warnecke (186114), Thomas Winkler (127802), Karl X. Knaup (186120), Gunnar Schley (186149), Kai-Uwe Eckardt (186164), Thomas Hackenbeck (186093), Robert Koesters (186139), Peter Betz (186146), Maxine Tran (186098), Johannes Schödel (186151), Carsten Willam (186156), Michael S. Wiesener (186173), Deepa Shukla (186127), Regina Günther (186104), Sebastian Bachmann (186143), Patrick Maxwell (186169), Kerstin Amann (186160)   +19 more
core   +1 more source

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer. [PDF]

PLoS ONE, 2015
It is well recognized that hypoxia-inducible factor 1 alpha (HIF-1α) is involved in cancer metastasis, chemotherapy and poor prognosis. We previously found that deferoxamine, a hypoxia-mimetic agent, induces epithelial-mesenchymal transition (EMT) in ...
Wenjing Zhang, Xinpeng Shi, Ying Peng, Meiyan Wu, Pei Zhang, Ruyi Xie, Yao Wu, Qingqing Yan, Side Liu, Jide Wang   +9 more
doaj   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Effects of HIF-1α on ERRα/γ protein expression in mouse skeletal muscle [PDF]

, 2015
Aims: HIF-1α plays an important role in the adaptive responses to hypoxia. The ERRα and γ are crucial regulators of energy metabolism in skeletal muscle.
Liu, Gang, Ji, Weixiu, Zhang, Lianfeng, Zhang, Ying, Wang, Jianxiong, Liu, Sixue   +5 more
core  

New insights into the key role of HIF-1α in IL-10-producing B cells [PDF]

, 2018
Hypoxia-inducible factors (HIFs) are essential transcription factors for the cellular response to hypoxia. Expression and stabilization of HIFs can be triggered by hypoxia or by other factors under pathological stress such as inflammation and infection ...
Xianyi Meng, Aline Bozec
core   +1 more source

ILKAP Binding to and Dephosphorylating HIF-1α is Essential for Apoptosis Induced by Severe Hypoxia

Cellular Physiology and Biochemistry, 2018
Background/Aims: Integrin-linked kinase-associated phosphatase (ILKAP), a serine/threonine phosphatase that belongs to the protein phosphatase 2C family, has a role in cell survival and apoptosis.
Tielong Liu, Yonggang Liu, Jiashi Cao, Xin Gao, Jing Wang, Guanghui Chen, Yang Wang, Ge Liu, Guangjian Bai, Yiwei Hu, Jiaxiang Yang, Lianfeng Dong, Xinbao Quan, Weiwei Zou   +13 more
doaj   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source