Results 91 to 100 of about 151,161 (274)
BMC Cancer, 2008 Background Hypoxia-inducible factor 1 alpha (HIF-1α) is involved in processes promoting carcinogenesis of many tumors. However, its role in the development of colorectal cancer is unknown.
Jayasinghe Caren +4 more
doaj +1 more source
3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress
Advanced Materials Technologies, EarlyView.Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi +4 more
wiley +1 more source
Hypoxia increases the expressions of HIF-1α and HIF-2α.
, 2013 (A) In comparison to the cells cultivated at 20% O2, the cells cultivated at 7% O2 show higher levels of HIF-1α and HIF-2α, and the cells cultivated at 1% O2 show the highest levels of HIF-1α and HIF-2α by both RT-PCR and immunoblotting.
Yuanyuan Ma (280707) +7 more
core +1 more source
Cellular Physiology and Biochemistry, 2013 Background/Aims: The mechanisms involved in endothelial barrier dysfunction induced by hypoxia are incompletely understood. There is debate about the role of hypoxia-inducible factor-1α (HIF-1α) in endothelial barrier disruption.
Pei Wang +6 more
doaj +1 more source
PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis-Associated Acute Lung Injury via AARS1-Mediated HIF-1α Lactylation. [PDF]
Adv Sci (Weinh)This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Li S +15 more
europepmc +2 more sources
Advanced Science, EarlyView.Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang +10 more
wiley +1 more source
EGC promotes HIF-1α proteasome pathway degradation.
, 2013 (A) Expression curve of HIF-1α under hypoxia. The results showed that the expression level of HIF-1α reached the peak at the 6th hour, but had a slight decrease after 10 hours; (B) EGC inhibited HIF-1α expression in a dose-dependent manner in both breast
Zhiyu Wang (282312) +8 more
core +1 more source
Advanced Science, EarlyView.This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li +14 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao +7 more
wiley +1 more source
HGF enhances HIF-1α activation.
, 2013 (A) OASFs were incubated with HGF for indicated time intervals, and HIF-1α expression was examined by Western blotting. (B) OASFs were incubated with HGF for indicated time intervals, and nucleus HIF-1α accumulation was determent by Western blotting. (C)
Ming-Chih Chou (296999) +5 more
core +1 more source