Results 91 to 100 of about 136,040 (279)

Downregulation of Hypoxia-Inducible Factor-1α by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats

Molecular Therapy: Nucleic Acids, 2020
Rheumatoid arthritis (RA) is the most common type of autoimmune arthritis. Hypoxia-inducible factor-1α (HIF-1α) as a transcription factor in response to hypoxia suggests that it could be a potential therapeutic target for the treatment of RA.
Yiping Hu, Tiantian Zhang, Jingqin Chen, WenXiang Cheng, Jianhai Chen, Zhengtan Zheng, Jietao Lin, Guoyuan Zhu, Yong Zhang, Xueling Bai, Yan Wang, Bing Song, Qingwen Wang, Ling Qin, Peng Zhang   +14 more
doaj   +1 more source

Analysis of HIF-1α-expression.

, 2015
Protein analysis for HIF-1α shows significant increase of HIF-1α-expression in hippocampal tissue 6h after SAH (A+B) independent from type of technique (Location of ICP-probe is hallmarked (+)).
Anke Höllig (721267), Rolf Rossaint (237), Agnieszka Weinandy (721268), Mark Coburn (173161), Hans Clusmann (721270), Kay Nolte (721269)   +5 more
core   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Age-Related Expression and Localization of HIF-1α and HIF-2α in Different Tissues of Yak

Oxygen
The yak (Bos grunniens), a unique bovine species that is endemic to the Qinghai–Tibet Plateau and adjacent mountainous regions, exhibits remarkable adaptations to chronic high-altitude hypoxia.
Qin Wu, Huan Yang, Junyu Chen, Zhixin Chai, Hongwen Zhao, Zhijuan Wu   +5 more
doaj   +1 more source

Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor. [PDF]

PLoS ONE, 2017
BACKGROUND:Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. Hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the cellular response to hypoxia and regulates the expression of multiple genes ...
Suguru Fukushima, Makoto Endo, Yoshihiro Matsumoto, Jun-Ichi Fukushi, Tomoya Matsunobu, Ken-Ichi Kawaguchi, Nokitaka Setsu, Keiichiro IIda, Nobuhiko Yokoyama, Makoto Nakagawa, Kenichiro Yahiro, Yoshinao Oda, Yukihide Iwamoto, Yasuharu Nakashima   +13 more
doaj   +1 more source

Hypoxia increases the expressions of HIF-1α and HIF-2α.

, 2013
(A) In comparison to the cells cultivated at 20% O2, the cells cultivated at 7% O2 show higher levels of HIF-1α and HIF-2α, and the cells cultivated at 1% O2 show the highest levels of HIF-1α and HIF-2α by both RT-PCR and immunoblotting.
Yuanyuan Ma (280707), Dongming Liang (280708), Zhenhe Suo (79154), Jian Liu (33711), Trond Stokke (66426), Jahn M. Nesland (205661), Gunnar Kvalheim (7747), Karol Axcrona (336664)   +7 more
core   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Hypoxia‐inducible factor (HIF)‐1α‐induced regulation of lung injury in pulmonary aspiration is mediated through NF‐kB

FASEB BioAdvances, 2022
Aspiration‐induced lung injury is a common grievance encountered in the intensive care unit (ICU). It is a significant risk factor for improving ventilator‐associated pneumonia (VAP) and acute respiratory distress syndrome (ARDS).
Madathilparambil V. Suresh, George Yalamanchili, Tejeshwar C. Rao, Sinan Aktay, Alex Kralovich, Yatrik M. Shah, Krishnan Raghavendran   +6 more
doaj   +1 more source

HIF-transcribed p53 chaperones HIF-1α

, 2019
Chronic hypoxia is associated with a variety of physiological conditions such as rheumatoid arthritis, ischemia/reperfusion injury, stroke, diabetic vasculopathy, epilepsy and cancer.
Pati, Uttam K., Carvalho, Carlos, Moreno, Eduardo, Madan, Esha, Chandaria, Aliya, Nagane, Masaki, Palma, Antonio M., Canas-Marques, Rita, Kuppusamy, Periannan, Tomás, Ana R., Gogna, Rajan, Parker, Taylor M., Beltran, Antonio, Peixoto, Maria L., Galzerano, Antonio, Cabral-Teixeira, Joaquim, Henriques, Vanessa, Selvendiran, Karuppaiyah, Pelham, Christopher J.   +18 more
core   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source