Results 1 to 10 of about 180,302 (314)

Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. [PDF]

PLoS ONE, 2017
Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible ...
Veronika Bäcker, Fung-Yi Cheung, Jens T Siveke, Joachim Fandrey, Sandra Winning   +4 more
doaj   +2 more sources

Intermittent hypoxic stimulation promotes efficient expression of Hypoxia-inducible factor-1α and exerts a chondroprotective effect in an animal osteoarthritis model. [PDF]

PLoS ONE
Hypoxia-inducible factor-1α plays an important role in the homeostasis of articular cartilage in hypoxic environments. Therefore, modulation of hypoxia-inducible factor-1α by regulating the oxygen environment could be a useful treatment for ...
Ryota Cha, Shuji Nakagawa, Yuji Arai, Atsuo Inoue, Naoki Okubo, Yuta Fujii, Kenta Kaihara, Kei Nakamura, Tsunao Kishida, Osam Mazda, Kenji Takahashi   +10 more
doaj   +2 more sources

Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease [PDF]

Frontiers in Pharmacology
Diabetic kidney disease is one of the common complications in diabetic patients and has gradually become an important pathogenic factor in chronic kidney disease.
Wei Qin, Ping Nie, Xuejun Hui, Fei Chen, Xingbao Hu, Wenjiao Shi, Manyu Luo, Bing Li   +7 more
doaj   +2 more sources

Glucose deprivation impairs hypoxia-inducible factor-1α synthesis [PDF]

Discover Oncology
Hypoxia-inducible factors (HIFs) are key transcriptional mediators of the hypoxic response and are implicated in oncogenesis. HIFα is regulated by a well-characterized, oxygen-dependent degradation pathway involving the von Hippel Lindau (VHL) tumor ...
Mia Hubert, Sarah Stuart, Michael Ohh
doaj   +2 more sources

The Difference in Average of Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Severe Preeclampsia

Andalas Obstetrics And Gynecology Journal, 2021
The purpose of this study is to know the difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M.
David Perdana, Defrin Defrin, Firdawati Firdawati   +2 more
openaire   +2 more sources

The Hypoxia-Inducible Factor-1α Signaling Pathway and its Relation to Cancer and Immunology [PDF]

American Journal of Immunology, 2014
Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is present in all metazoans from early embryonic development throughout adult life. It plays a major roles in the different stress responses that are triggered by low Oxygen (O2) levels and its expression is associated with cell survival. HIF-1 is a heterodimer protein that comprises the
Bruno R.B. Pires, Andre L. Mencalha, Gerson M. Ferreira, Carolina Panis, Rafael C.M.C. Silva, Eliana Abdelhay   +5 more
openaire   +1 more source

Hypoxia Inducible Factor-1α Attenuates Ischemic Brain Damage by Modulating Inflammatory Response and Glial Activity

Cells, 2021
Hypoxia-inducible factor 1 can sufficiently control the progress of neurological symptoms after ischemic stroke owing to their actions associated with its downstream genes.
Nashwa Amin, Shijia Chen, Qiannan Ren, Xiaoning Tan, Benson O. A. Botchway, Zhiying Hu, Fengpei Chen, Shan Ye, Xiaoxue Du, Zuobing Chen, Marong Fang   +10 more
doaj   +1 more source

Hypoxia-Inducible Factor 1α Expression in Chorionic Tissue and Decidua of Women with Spontaneous Abortion at the First Trimester of Pregnancy [PDF]

American Journal of Biochemistry and Biotechnology, 2014
Oxygen-regulated genes expression has important role in pre-implantation embryonic metabolism regulation. Hypoxia Inducible Factor (HIF) regulated by hypoxia oxygen tension is crucial for placenta development. But the data about its role in spontaneous abortion is very poor. Thus, we aimed to determine an expression level of HIF-1I± in chorionic tissue
E. V. Mashkina, K. A. Kovalenko, E. V. Butenko   +2 more
openaire   +1 more source

MiR-335 Regulates Hif-1α to Reduce Cell Death in Both Mouse Cell Line and Rat Ischemic Models. [PDF]

PLoS ONE, 2015
Hypoxia inducible factor-1α facilitates cellular adaptation to hypoxic conditions. Hence its tight regulation is crucial in hypoxia related diseases such as cerebral ischemia.
Fu Jia Liu, Prameet Kaur, Dwi S Karolina, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Peter T H Wong, Kandiah Jeyaseelan   +6 more
doaj   +1 more source

SIRT3 inhibition suppresses hypoxia‐inducible factor 1α signaling and alleviates hypoxia‐induced apoptosis of type B spermatogonia GC‐2 cells

FEBS Open Bio, 2023
Hypoxia has been reported to be an important factor leading to male infertility, and it has been reported that hypoxia can induce the apoptosis of mouse spermatogenic cells.
Zixuan Wang, Chunchun Zhu, Yangyang Song, Xiaoyun Chen, Jie Zheng, Lian He, Xing Liu, Zhu Chen   +7 more
doaj   +1 more source