Results 11 to 20 of about 122,157 (267)

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells. [PDF]

PLoS ONE, 2011
DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival. Here, we demonstrate that hypoxia inducible factor-1α
Mahendran Botlagunta, Balaji Krishnamachary, Farhad Vesuna, Paul T Winnard, Guus M Bol, Arvind H Patel, Venu Raman   +6 more
doaj   +2 more sources

Research progress of hypoxia inducible factor 1α in the mechanism of diabetic kidney disease [PDF]

Jichu yixue yu linchuang
Hypoxia-inducible factor-1α (HIF-1α) is a nuclear transcription factor. Under high glucose and hypoxia conditions, the expression of HIF-1α is elevated, result in the increased expression of its downstream target genes VEGF, HO-1 and BNIP3, which affect ...
ZHANG Yahui, BAI Qiong
doaj   +2 more sources

SIRT3 inhibition suppresses hypoxia‐inducible factor 1α signaling and alleviates hypoxia‐induced apoptosis of type B spermatogonia GC‐2 cells

FEBS Open Bio, 2023
Hypoxia has been reported to be an important factor leading to male infertility, and it has been reported that hypoxia can induce the apoptosis of mouse spermatogenic cells.
Zixuan Wang, Chunchun Zhu, Yangyang Song, Xiaoyun Chen, Jie Zheng, Lian He, Xing Liu, Zhu Chen   +7 more
doaj   +1 more source

The HIF‐1α pathway plays a critical role in salivary gland development in ex vivo organ cultures

FEBS Open Bio, 2022
The transcription factor, hypoxia‐inducible factor‐1α (HIF‐1α), has previously been shown to upregulate the expression of hypoxia‐related genes, including erythropoietin (EPO).
Tomomasa Kimura, Manabu Sakai, Nao Gojo, Mikio Watanabe, Narikazu Uzawa, Takayoshi Sakai   +5 more
doaj   +1 more source

Obstructive sleep apnea aggravates neuroinflammation and pyroptosis in early brain injury following subarachnoid hemorrhage via ASC/HIF-1α pathway

Neural Regeneration Research, 2022
[INLINE:1] Obstructive sleep apnea can worsen the prognosis of subarachnoid hemorrhage. However, the underlying mechanism remains unclear. In this study, we established a mouse model of subarachnoid hemorrhage using the endovascular perforation method ...
Jun Xu, Qian Li, Chen-Yu Xu, Shan Mao, Jia-Jia Jin, Wei Gu, Ying Shi, Chun-Fang Zou, Liang Ye   +8 more
doaj   +1 more source

Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats

Neural Regeneration Research, 2021
Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains.
Qiu-Shi Gao, Ya-Han Zhang, Hang Xue, Zi-Yi Wu, Chang Li, Ping Zhao   +5 more
doaj   +1 more source

Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats

Neural Regeneration Research, 2019
Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available.
Tao Wang, Li-Ni Zeng, Zhe Zhu, Yu-Hui Wang, Lu Ding, Wei-Bin Luo, Xiao-Min Zhang, Zhi-Wei He, Hong-Fu Wu   +8 more
doaj   +1 more source

Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]

, 2005
Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core   +1 more source

Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown

BMC Research Notes, 2018
Objective Earlier studies from our group using hypoxia-inducible factor 3α knockout mice showed impairments in lung remodeling and lung endothelial cells.
Firman Zulkifli Amin, Toshiharu Yamashita, Osamu Ohneda   +2 more
doaj   +1 more source

Compound C prevents Hypoxia-Inducible Factor-1α protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I

BMC Research Notes, 2011
The transcription factor Hypoxia-Inducible Factor-1α is a master regulator of the cellular response to low oxygen concentration. Compound C, an inhibitor of AMP-activated kinase, has been reported to inhibit hypoxia dependent Hypoxia-Inducible Factor-1α ...
Hagen Thilo, Chua Yee Liu
doaj   +1 more source