Results 11 to 20 of about 180,302 (314)
Frontiers in Immunology, 2023 Hypoxia-inducible factor-1α (HIF-1α) is a primary metabolic sensor, and is expressed in different immune cells, such as macrophage, dendritic cell, neutrophil, T cell, and non-immune cells, for instance, synovial fibroblast, and islet β cell.
Yangshun Tang +4 more
semanticscholar +1 more source
Hypoxia inducible factor-1α is an important regulator of macrophage biology
Heliyon, 2023 Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate
Bingquan Qiu +5 more
semanticscholar +1 more source
Biological Functions and Regulatory Mechanisms of Hypoxia-Inducible Factor-1α in Ischemic Stroke
Frontiers in Immunology, 2021 Ischemic stroke is caused by insufficient cerebrovascular blood and oxygen supply. It is a major contributor to death or disability worldwide and has become a heavy societal and clinical burden.
Qianyan He +8 more
semanticscholar +1 more source
The HIF‐1α pathway plays a critical role in salivary gland development in ex vivo organ cultures
FEBS Open Bio, 2022 The transcription factor, hypoxia‐inducible factor‐1α (HIF‐1α), has previously been shown to upregulate the expression of hypoxia‐related genes, including erythropoietin (EPO).
Tomomasa Kimura +5 more
doaj +1 more source
Neural Regeneration Research, 2022 [INLINE:1] Obstructive sleep apnea can worsen the prognosis of subarachnoid hemorrhage. However, the underlying mechanism remains unclear. In this study, we established a mouse model of subarachnoid hemorrhage using the endovascular perforation method ...
Jun Xu +8 more
doaj +1 more source
Bioengineered, 2021 Cardiomyocyte apoptosis and autophagy play important roles in acute myocardial infarction (AMI), but the effect of leucine-rich alpha-2-glycoprotein 1 (LRG1) on the apoptosis and autophagy of H9c2 has not yet been reported.
Jiajie Feng +2 more
semanticscholar +1 more source
Neural Regeneration Research, 2021 Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains.
Qiu-Shi Gao +5 more
doaj +1 more source
Neural Regeneration Research, 2019 Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available.
Tao Wang +8 more
doaj +1 more source
Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal cancer—the relationship with regulatory hypoxia-inducible factor-1α expression, tumor invasiveness, and patient prognosis [PDF]
, 2014 Increased glucose uptake mediated by glucose transporters and reliance on glycolysis are common features of malignant cells. Hypoxia-inducible factor-1α supports the adaptation of hypoxic cells by inducing genes related to glucose metabolism.
Anna Krześlak +51 more
core +1 more source