Results 1 to 10 of about 185,754 (313)

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells. [PDF]

PLoS ONE, 2011
DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival. Here, we demonstrate that hypoxia inducible factor-1α
Mahendran Botlagunta, Balaji Krishnamachary, Farhad Vesuna, Paul T Winnard, Guus M Bol, Arvind H Patel, Venu Raman   +6 more
doaj   +2 more sources

Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis [PDF]

Cellular & Molecular Biology Letters
Background Glucocorticoids (GCs) are key regulators of hematopoiesis, but the effects of chronically elevated endogenous GC levels on hematopoietic stem cell (HSC) function and immune cell development remain poorly understood.
Deepika Watts, Nicolas Eberz, Mangesh T. Jaykar, Anupam Sinha, Cagdas Ermis, Johanna Tiebel, Ulrike Baschant, Martina Rauner, Tatyana Grinenko, Triantafyllos Chavakis, Peter Mirtschink, Ali El-Armouche, Ben Wielockx   +12 more
doaj   +2 more sources

Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis

Clinical and Experimental Gastroenterology, 2014
Ram Gupta,1 Anita R Chaudhary,2 Binita N Shah,1 Avinash V Jadhav,3 Shitalkumar P Zambad,1 Ramesh Chandra Gupta,4 Shailesh Deshpande,4 Vijay Chauthaiwale,4 Chaitanya Dutt4 1Department of Pharmacology, 2Cellular and Molecular Biology, 3Preclinical Safety ...
Gupta R, Chaudhary AR, Shah BN, Jadhav AV, Zambad SP, Gupta RC, Deshpande S, Chauthaiwale V, Dutt C   +8 more
doaj   +1 more source

Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. [PDF]

PLoS ONE, 2017
Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible ...
Veronika Bäcker, Fung-Yi Cheung, Jens T Siveke, Joachim Fandrey, Sandra Winning   +4 more
doaj   +1 more source

Hypoxia-Inducible Factors and Cancer [PDF]

Current Sleep Medicine Reports, 2017
Hypoxia inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell ...
Jonathan C, Jun, Aman, Rathore, Haris, Younas, Daniele, Gilkes, Vsevolod Y, Polotsky   +4 more
openaire   +2 more sources

Hypoxia Inducible Factor-1α Attenuates Ischemic Brain Damage by Modulating Inflammatory Response and Glial Activity

Cells, 2021
Hypoxia-inducible factor 1 can sufficiently control the progress of neurological symptoms after ischemic stroke owing to their actions associated with its downstream genes.
Nashwa Amin, Shijia Chen, Qiannan Ren, Xiaoning Tan, Benson O. A. Botchway, Zhiying Hu, Fengpei Chen, Shan Ye, Xiaoxue Du, Zuobing Chen, Marong Fang   +10 more
doaj   +1 more source

Hypoxia-inducible factors and diabetes [PDF]

Journal of Clinical Investigation, 2020
Hypoxia can be defined as a relative deficiency in the amount of oxygen reaching the tissues. Hypoxia-inducible factors (HIFs) are critical regulators of the mammalian response to hypoxia. In normal circumstances, HIF-1α protein turnover is rapid, and hyperglycemia further destabilizes the protein.
openaire   +2 more sources

The human side of hypoxia‐inducible factor [PDF]

British Journal of Haematology, 2008
SummaryWhen humans are exposed to hypoxia, systemic and intracellular changes operate together to minimise hypoxic injury and restore adequate oxygenation. Emerging evidence indicates that the hypoxia‐inducible factor (HIF) family of transcription factors plays a central regulatory role in these homeostatic changes at both the systemic and cellular ...
Smith, T, Robbins, P, Ratcliffe, P
openaire   +3 more sources

Hypoxia-Inducible Factor in Thyroid Carcinoma [PDF]

Journal of Thyroid Research, 2011
Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy.
Burrows, Natalie, Babur, Muhammad, Resch, Julia, Williams, Kaye J, Brabant, Georg   +4 more
openaire   +3 more sources

Advances in Hypoxia-Inducible Factor Biology [PDF]

Cell Metabolism, 2018
Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis and metabolic activation. Beyond this, HIF influences many other processes. Hypoxia, in part through HIF-dependent mechanisms, influences epigenetic factors, including DNA methylation ...
Choudhry, H, Harris, A
openaire   +3 more sources