Results 1 to 10 of about 1,590,992 (346)

Pola MRNA Hypoxia Inducible Factor-1? (HIF-1?) Dan Exkspresi Protein HIF-1? Ginjal Tikus Pada Hipoksia Sistemik Kronik [PDF]

, 2012
Kspresiprotein HIF-1? pada organ ginjal dari tikus yang mengalamikondisi hipoksia secara sistemik menggunakan Hypoxic Chamber dengankadar O2 8% dan Nitrogen 92% dan kelompok kontrol pada kondisinormoksia. Pola mRNA HIF-1? dilihat berdasarkan hasil RT-PCR
Suciati, Y. (Yulia)
core  

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer.
Blokland, NJG, Broos, AWT, Eccles, SA, Hammond, EM, Harvey, AJ, Pires, IM, Poujade, F-A, Senra, JM, Span, PN   +8 more
core   +4 more sources

Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia

Haematologica, 2012
Background Congenital secondary erythrocytoses are due to deregulation of hypoxia inducible factor resulting in overproduction of erythropoietin. The most common germline mutation identified in the hypoxia signaling pathway is the Arginine 200-Tryptophan
Charline Ladroue, David Hoogewijs, Sophie Gad, Romain Carcenac, Federica Storti, Michel Barrois, Anne-Paule Gimenez-Roqueplo, Michel Leporrier, Nicole Casadevall, Olivier Hermine, Jean-Jacques Kiladjian, André Baruchel, Fadi Fakhoury, Brigitte Bressac-de Paillerets, Jean Feunteun, Nathalie Mazure, Jacques Pouysségur, Roland H. Wenger, Stéphane Richard, Betty Gardie   +19 more
doaj   +1 more source

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.

Genes & Development, 2002
Mammalian cells adapt to hypoxic conditions through a transcriptional response pathway mediated by the hypoxia-inducible factor, HIF. HIF transcriptional activity is suppressed under normoxic conditions by hydroxylation of an asparagine residue within ...
D. Lando, D. Peet, J. Gorman, Dean A Whelan, M. Whitelaw, R. Bruick   +5 more
semanticscholar   +1 more source

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells [PDF]

, 2013
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors.
Court, William, Cuda, F., Eccles, Suzanne A., Fox, Keith R., Hoakwie, Franciane, Lawrence, Charlotte, Male, Abigail, Miranda, Elena, Nordgren, Ida, Packham, Graham K., Tavassoli, Ali, Townsend, Paul   +11 more
core   +1 more source

HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells

Tumor Biology, 2017
Long-term persistent infection of HPV16 E6/E7 is frequently associated with lung cancers, especially in non-smokers and in Asians. However, molecular mechanisms of HPV16 E6/E7 induction of lung cancer are not fully understood.
Jian-Shuang Shao, Jian Sun, Shiyu Wang, Katherine Chung, Jin Tong Du, Jason Wang, Xue-Shan Qiu, En-Hua Wang, Guang-Ping Wu   +8 more
doaj   +1 more source

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

Frontiers in Oncology, 2017
Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers. Its canonical regulation involves prolyl hydroxylases (PHDs), which in
L. Iommarini, A. Porcelli, G. Gasparre, I. Kurelac   +3 more
semanticscholar   +1 more source

mRNA expression profile of selected oxygen sensing genes in the lung during recovery from chronic hypoxia

Biological Research, 2013
This study analyzed the time dependence decay of the mRNA of selected genes important for the hypoxia response. The genes chosen were the two isoforms of hypoxia-inducible factors, the three isoforms of the prolyl hydroxylase domain protein, the vascular
Alice Panariti, Giuseppe Miserocchi, Ilaria Rivolta   +2 more
doaj   +1 more source

Hypoxia helps glioma to fight therapy [PDF]

, 2009
Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena
core   +1 more source

Sub-Sets of Cancer Stem Cells Differ Intrinsically in Their Patterns of Oxygen Metabolism [PDF]

, 2013
PMCID: PMC3640080This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Adrian Biddle, Anne C. Johannessen, DM Brizel, E Gemenetzidis, E Louie, E Sasabe, E Sasabe, G Dontu, GL Semenza, H Wang, H Zhang, H Zhong, Hannah K. Heywood, HK Heywood, I Papandreou, Ian C. Mackenzie, JP Thiery, JW Kim, LJ Harper, LJ Harper, Luke Gammon, M Al-Hajj, M Diehn, M Wartenberg, ME Prince, MF Clarke, MH Yang, MH Yang, MK Ayrapetov, O Warburg, O Warburg, P van Uden, PB Gupta, PD Sutphin, PJ Kallio, Q Li, R Sullivan, RD Lester, SA Mani, SM Wigfield, SS Prime, T Brabletz, T McFate, Yao Liang Tang   +43 more
core   +9 more sources