Results 21 to 30 of about 4,288,026 (254)

Hypoxia-inducible factors in OSCC

Cancer Letters, 2011
Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF).
Pérez Sayáns, Mario, Barros Angueira, Francisco, Gayoso Diz, Pilar, García García, Abel, Suárez Peñaranda, Jose Manuel, Gándara Rey, José Manuel   +5 more
openaire   +3 more sources

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]

, 2014
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival ...
Biddlestone, John, Mudie, Sharon, Bandarra, Daniel, Muller, H. Arno, Rocha, Sonia   +4 more
core   +1 more source

Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils [PDF]

, 2012
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the angiogenic ...
Claire L Streatfield, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Streatfield, Claire L., Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Streatfield Claire L., Yasinska Inna, Sumbayev Vadim V., Inna Yasinska, Oniku Abraham E., Gibbs Bernhard F., Abraham E Oniku   +14 more
core   +2 more sources

Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells [PDF]

, 2011
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117.
Bernhard F. Gibbs, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Vadim V. Sumbayev, Inna M Yasinska, Abraham E. Oniku, Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Abraham E Oniku, Inna M. Yasinska   +11 more
core   +2 more sources

Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells

Haematologica, 2010
Background Multiple myeloma is an incurable malignancy of bone marrow plasma cells. Progression of multiple myeloma is accompanied by an increase in bone marrow angiogenesis.
Sally K. Martin, Peter Diamond, Sharon A. Williams, Luen Bik To, Daniel J. Peet, Nobutaka Fujii, Stan Gronthos, Adrian L. Harris, Andrew C.W. Zannettino   +8 more
doaj   +1 more source

Hypoxia-inducible factors in the kidney [PDF]

American Journal of Physiology-Renal Physiology, 2006
Tissue hypoxia not only occurs under pathological conditions but is also an important microenvironmental factor that is critical for normal embryonic development. Hypoxia-inducible factors HIF-1 and HIF-2 are oxygen-sensitive basic helix-loop-helix transcription factors, which regulate biological processes that facilitate both oxygen delivery and ...
openaire   +2 more sources

Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways [PDF]

, 2013
The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer; however, little is known ...
Ashcroft, M, Carroll, VA, Selvarajah, J, Moumen, A, Nathawat, K   +4 more
core   +2 more sources

Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]

, 2005
Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core   +1 more source

Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1

Molecules, 2018
Induction of a series of anti-hypoxic proteins protects cells during exposure to hypoxic conditions. Hypoxia-inducible factor-α (HIF-α) is a major transcription factor that orchestrates this protective effect.
Shin-ichi Kawaguchi, Yuhei Gonda, Takuya Yamamoto, Yuki Sato, Hiroyuki Shinohara, Yohsuke Kobiki, Atsuhiko Ichimura, Takashi Dan, Motohiro Sonoda, Toshio Miyata, Akiya Ogawa, Tadayuki Tsujita   +11 more
doaj   +1 more source

Roxadustat: Not just for anemia

Frontiers in Pharmacology, 2022
Roxadustat is a recently approved hypoxia-inducible factor prolyl hydroxylase inhibitor that has demonstrated favorable safety and efficacy in the treatment of renal anemia.
Xiaoyu Zhu, Lili Jiang, Xuejiao Wei, Mengtuan Long, Yujun Du   +4 more
doaj   +1 more source