Results 21 to 30 of about 1,590,992 (346)

Autophagy degrades hypoxia inducible factors [PDF]

Molecular & Cellular Oncology, 2016
Hypoxia inducible factors are subjected to degradation by the ubiquitin-proteasome system (UPS), macroautophagy, and chaperone-mediated autophagy. The E3 ligases, ubiquitination, autophagy receptor proteins, and oxygen are determinants that direct hypoxia-inducible factors to different degradation pathways.
Adela, DePavia, Eric, Jonasch, Xian-De, Liu   +2 more
openaire   +2 more sources

MiR-335 Regulates Hif-1α to Reduce Cell Death in Both Mouse Cell Line and Rat Ischemic Models. [PDF]

PLoS ONE, 2015
Hypoxia inducible factor-1α facilitates cellular adaptation to hypoxic conditions. Hence its tight regulation is crucial in hypoxia related diseases such as cerebral ischemia.
Fu Jia Liu, Prameet Kaur, Dwi S Karolina, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Peter T H Wong, Kandiah Jeyaseelan   +6 more
doaj   +1 more source

Hypoxia-inducible factor signaling in pulmonary hypertension.

Journal of Clinical Investigation, 2020
Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can subsequently culminate in right heart failure and premature death.
S. Pullamsetti, Argen Mamazhakypov, N. Weissmann, W. Seeger, R. Savai   +4 more
semanticscholar   +1 more source

Hypoxia-Inducible Factors and Cancer [PDF]

Current Sleep Medicine Reports, 2017
Hypoxia inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell ...
Jonathan C, Jun, Aman, Rathore, Haris, Younas, Daniele, Gilkes, Vsevolod Y, Polotsky   +4 more
openaire   +2 more sources

Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown

BMC Research Notes, 2018
Objective Earlier studies from our group using hypoxia-inducible factor 3α knockout mice showed impairments in lung remodeling and lung endothelial cells.
Firman Zulkifli Amin, Toshiharu Yamashita, Osamu Ohneda   +2 more
doaj   +1 more source

Hypoxia-inducible factors and diabetes [PDF]

Journal of Clinical Investigation, 2020
Hypoxia can be defined as a relative deficiency in the amount of oxygen reaching the tissues. Hypoxia-inducible factors (HIFs) are critical regulators of the mammalian response to hypoxia. In normal circumstances, HIF-1α protein turnover is rapid, and hyperglycemia further destabilizes the protein.
openaire   +2 more sources

SnapShot: Hypoxia-Inducible Factors

Cell, 2015
Molecular oxygen (O2) is a key substrate for mitochondrial ATP production and numerous intracellular biochemical reactions. The maintenance of O2 homeostasis is therefore essential for the survival of most species. During O2 deprivation, mammalian cells rely on multiple adaptations mediated by the hypoxia-inducible factors (HIFs), mTOR, autophagy, and ...
Lee, Kyoung Eun, Simon, M. Celeste
openaire   +2 more sources

Hypoxia-Inducible Factor in Thyroid Carcinoma [PDF]

Journal of Thyroid Research, 2011
Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy.
Burrows, Natalie, Babur, Muhammad, Resch, Julia, Williams, Kaye J, Brabant, Georg   +4 more
openaire   +3 more sources

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.

Genes & Development, 1998
Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality.
N. Iyer, L. Kotch, F. Agani, S. Leung, E. Laughner, R. Wenger, M. Gassmann, J. Gearhart, A. Lawler, A. Yu, G. Semenza   +10 more
semanticscholar   +1 more source

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]

, 2014
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
An, Azad, Bartels, Bonello, Centanin, Culver, Cummins, Cummins, Daniel Bandarra, Dekanty, Fandrey, Fu, Glittenberg, H. Arno Muller, Harhaj, Hetru, Jiang, John Biddlestone, Jono, Kenneth, Kounatidis, Lando, Lavista-Llanos, Liu, Lu, Massoumi, Melvin, Moniz, Perkins, Perkins, Ratcliffe, Rius, Rocha, Romero, Ruland, Scholz, Semenza, Sharon Mudie, Silke, Silverman, Silverman, Sonia Rocha, Sonnenfeld, Tornatore, Tsichritzis, van Uden, van Uden, Walmsley, Xue   +48 more
core   +5 more sources