Results 21 to 30 of about 139,429 (264)

Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats

Neural Regeneration Research, 2019
Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available.
Tao Wang, Li-Ni Zeng, Zhe Zhu, Yu-Hui Wang, Lu Ding, Wei-Bin Luo, Xiao-Min Zhang, Zhi-Wei He, Hong-Fu Wu   +8 more
doaj   +1 more source

Hypoxia-inducible factors in the kidney [PDF]

American Journal of Physiology-Renal Physiology, 2006
Tissue hypoxia not only occurs under pathological conditions but is also an important microenvironmental factor that is critical for normal embryonic development. Hypoxia-inducible factors HIF-1 and HIF-2 are oxygen-sensitive basic helix-loop-helix transcription factors, which regulate biological processes that facilitate both oxygen delivery and ...
openaire   +2 more sources

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells.

PLoS ONE, 2011
DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival. Here, we demonstrate that hypoxia inducible factor-1α
Mahendran Botlagunta, Balaji Krishnamachary, Farhad Vesuna, Paul T Winnard, Guus M Bol, Arvind H Patel, Venu Raman   +6 more
doaj   +1 more source

Ginsenoside 20(S)-Rg3 suppresses ovarian cancer migration via hypoxia-inducible factor 1 alpha and nuclear factor-kappa B signals

Tumor Biology, 2017
Hypoxia-inducible factor 1 is believed to play a prominent role in the survival and developing progress of cancers. As a result, inhibiting α subunit of hypoxia-inducible factor 1 represents an attractive strategy against tumor.
Ting Liu, Le Zhao, Huilian Hou, Lu Ding, Wei Chen, Xu Li   +5 more
doaj   +1 more source

Obstructive sleep apnea aggravates neuroinflammation and pyroptosis in early brain injury following subarachnoid hemorrhage via ASC/HIF-1α pathway

Neural Regeneration Research, 2022
[INLINE:1] Obstructive sleep apnea can worsen the prognosis of subarachnoid hemorrhage. However, the underlying mechanism remains unclear. In this study, we established a mouse model of subarachnoid hemorrhage using the endovascular perforation method ...
Jun Xu, Qian Li, Chen-Yu Xu, Shan Mao, Jia-Jia Jin, Wei Gu, Ying Shi, Chun-Fang Zou, Liang Ye   +8 more
doaj   +1 more source

SnapShot: Hypoxia-Inducible Factors

Cell, 2015
Molecular oxygen (O2) is a key substrate for mitochondrial ATP production and numerous intracellular biochemical reactions. The maintenance of O2 homeostasis is therefore essential for the survival of most species. During O2 deprivation, mammalian cells rely on multiple adaptations mediated by the hypoxia-inducible factors (HIFs), mTOR, autophagy, and ...
Lee, Kyoung Eun, Simon, M. Celeste
openaire   +2 more sources

Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition

Tumor Biology, 2017
Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma by activating the key transcription factor, hypoxia-inducible factor-1.
Ming Ye, Zejun Fang, Hongqian Gu, Rui Song, Jiangwei Ye, Hongzhang Li, Zhiguang Wu, Shenghui Zhou, Peng Li, Xiang Cai, Xiaokun Ding, Songshan Yu   +11 more
doaj   +1 more source

Hypoxia-inducible factors in OSCC

Cancer Letters, 2011
Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF).
Pérez Sayáns, Mario, Barros Angueira, Francisco, Gayoso Diz, Pilar, García García, Abel, Suárez Peñaranda, Jose Manuel, Gándara Rey, José Manuel   +5 more
openaire   +3 more sources

Autophagy degrades hypoxia inducible factors [PDF]

Molecular & Cellular Oncology, 2016
Hypoxia inducible factors are subjected to degradation by the ubiquitin-proteasome system (UPS), macroautophagy, and chaperone-mediated autophagy. The E3 ligases, ubiquitination, autophagy receptor proteins, and oxygen are determinants that direct hypoxia-inducible factors to different degradation pathways.
Adela, DePavia, Eric, Jonasch, Xian-De, Liu   +2 more
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Hypoxia and Hypoxia-Inducible Factors in Lymphedema

Frontiers in Pharmacology, 2022
Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease.
Xinguo Jiang, Xinguo Jiang, Wen Tian, Wen Tian, Dongeon Kim, Dongeon Kim, Alexander S. McQuiston, Alexander S. McQuiston, Ryan Vinh, Ryan Vinh, Stanley G. Rockson, Gregg L. Semenza, Mark R. Nicolls, Mark R. Nicolls   +13 more
openaire   +3 more sources