Results 31 to 40 of about 4,288,026 (254)
Molecular Pain, 2019 Chemotherapy-induced painful peripheral neuropathy is a significant clinical problem that is associated with widely used chemotherapeutics. Unfortunately, the molecular mechanisms by which chemotherapy-induced painful peripheral neuropathy develops have ...
Taylor Ludman, Ohannes K Melemedjian
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BMC Research Notes, 2011 The transcription factor Hypoxia-Inducible Factor-1α is a master regulator of the cellular response to low oxygen concentration. Compound C, an inhibitor of AMP-activated kinase, has been reported to inhibit hypoxia dependent Hypoxia-Inducible Factor-1α ...
Hagen Thilo, Chua Yee Liu
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مجله دانشکده پزشکی اصفهان, 2019 Oxygen deficiency, referred to as hypoxia, can be divided into two categories of environmental (exogenous) which is sensitized by respiratory cells, and microenvironmental (endogenous) responses by other cells in the body, like cancer cells.
Fatemeh Choopani +4 more
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Dose-dependent effects of Allopurinol on human foreskin fibroblast cell and human umbilical vein endothelial cell under hypoxia [PDF]
, 2015 Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia ...
Sun, Yu +8 more
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FEBS Open Bio, 2023 Hypoxia has been reported to be an important factor leading to male infertility, and it has been reported that hypoxia can induce the apoptosis of mouse spermatogenic cells.
Zixuan Wang +7 more
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Neural Regeneration Research, 2021 Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains.
Qiu-Shi Gao +5 more
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Hypoxia-induced signaling in angiogenesis : role of mTOR, HIF and Angiotensin II [PDF]
, 2007 This thesis includes the work of four different projects I have been following during my time as a PhD student; (1) the characterization of mTOR-associated signaling and endothelial cell proliferation in response to hypoxia, and (2) identification of ...
Petrimpol, Marco Renato
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The updated biology of hypoxia‐inducible factor [PDF]
The EMBO Journal, 2012 Oxygen is essential for eukaryotic life and is inextricably linked to the evolution of multicellular organisms. Proper cellular response to changes in oxygen tension during normal development or pathological processes, such as cardiovascular disease and cancer, is ultimately regulated by the transcription factor, hypoxia-inducible factor (HIF).
Samantha N, Greer +3 more
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Patologìâ, 2017 The purpose of this study was to establish the features of the expression of hif‑1α and hif-3α genes and the accumulation of HIF-1α and HIF-3α proteins in the paraventricular (PVH) and supraoptic (SO) nuclei of the hypothalamus under the conditions of ...
A. V. Abramov, V. A. Shamenko
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Autophagy degrades hypoxia inducible factors [PDF]
Molecular & Cellular Oncology, 2016 Hypoxia inducible factors are subjected to degradation by the ubiquitin-proteasome system (UPS), macroautophagy, and chaperone-mediated autophagy. The E3 ligases, ubiquitination, autophagy receptor proteins, and oxygen are determinants that direct hypoxia-inducible factors to different degradation pathways.
Adela, DePavia +2 more
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