Results 51 to 60 of about 139,429 (264)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional regulation by hypoxia inducible factors [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2013
The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia.
Veronica L, Dengler, Matthew, Galbraith, Joaquín M, Espinosa   +2 more
openaire   +2 more sources

Hypoxia induces oncogene yes-associated protein 1 nuclear translocation to promote pancreatic ductal adenocarcinoma invasion via epithelial–mesenchymal transition

Tumor Biology, 2017
Pancreatic ductal adenocarcinoma is one of the most lethal cancers. The Hippo pathway is involved in tumorigenesis and remodeling of tumor microenvironments.
Honglong Wei, Zongzhen Xu, Feng Liu, Fuhai Wang, Xin Wang, Xueying Sun, Jie Li   +6 more
doaj   +1 more source

Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Frontiers in Immunology, 2018
Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms ...
Valentin Schatz, Patrick Neubert, Franz Rieger, Jonathan Jantsch   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Hypoxia-Inducible Factors [PDF]

RCSB Protein Data Bank, 2019
Robert L. Sainburg, Andrew L. Clark, George E. Billman, Zachary J. Schlader, Toby Mündel, Kevin Milne, Earl G. Noble, Felipe Querol, Sofia Pérez-Alenda, José A. Aznar, Stavros Apostolakis, Gregory Y. H. Lip, W. Todd Cade, Kevin E. Yarasheski, Linda S. Pescatello, R. H. Fagard, Fabio Manfredini, Roberto Manfredini, Nancy J. Rehrer, Lawrence E. Armstrong, Gemma A. McLeod, Louise Østergaard, Max Gassmann, Luigi Varesio, Michele Samaja, Michael Vogt, Fabio Breil, Hans Hoppeler   +27 more
  +5 more sources

Hypoxia-inducible factor-1 alpha expression in endometriosis: A retrospective observational case–control study of ovarian cyst capsules and endometrial tissue samples

Journal of International Medical Research
Background This study aimed to compare the expression patterns of hypoxia-inducible factor-1α in ovarian cyst capsules and endometrial tissue samples from patients with and without endometriosis to evaluate its potential as a biomarker of hypoxia in ...
Ezgi Tolu Cenk, Ceyda Sancakli Usta, Akin Usta, Gulay Turan, Gurhan Guney, Selim Afsar, Mine Islimye Taskin   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Hypoxia Inducible Factor-2α in Cancer [PDF]

Cell Cycle, 2007
Poorly oxygenated (hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels.
Tobias, Löfstedt, Erik, Fredlund, Linda, Holmquist-Mengelbier, Alexander, Pietras, Marie, Ovenberger, Lorenz, Poellinger, Sven, Påhlman   +6 more
openaire   +2 more sources

Expression of aldehyde dehydrogenase after neoadjuvant chemotherapy is associated with expression of hypoxia-inducible factors 1 and 2 alpha and predicts prognosis in locally advanced breast cancer

Clinics, 2013
OBJECTIVE: To analyze the expression of hypoxia-inducible factors (hypoxia-inducible factor 1A and hypoxia-inducible factor 2A) and aldehyde dehydrogenase proteins in patients with locally advanced breast carcinoma who were subjected to neoadjuvant ...
Daniel Guimarães Tiezzi, Willian Simões Clagnan, Larissa Raquel Mouro Mandarano, Christiani Bisinoto de Sousa, Heitor Ricardo Cosiski Marana, Marcelo Guimarães Tiezzi, Jurandyr Moreira de Andrade   +6 more
doaj