Results 71 to 80 of about 185,754 (313)

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +1 more source

Hypoxia Inducible Factor-2α in Cancer [PDF]

Cell Cycle, 2007
Poorly oxygenated (hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels.
Tobias, Löfstedt, Erik, Fredlund, Linda, Holmquist-Mengelbier, Alexander, Pietras, Marie, Ovenberger, Lorenz, Poellinger, Sven, Påhlman   +6 more
openaire   +2 more sources

Research advances on hypoxia inducible factor and diabetic nephropathy

Linchuang shenzangbing zazhi
As one of the major microvascular complications of diabetes, diabetic kidney disease (DKD) is one of the major causes of end-stage renal disease (ESRD).
Ye-ping Ma, Zhong-xin. Li
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hypoxia and hypoxia-inducible factors in neuroblastoma [PDF]

Cell and Tissue Research, 2017
Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.
Påhlman, Sven, Mohlin, Sofie
openaire   +2 more sources

Hypoxia-Inducible Factors [PDF]

RCSB Protein Data Bank, 2019
Robert L. Sainburg, Andrew L. Clark, George E. Billman, Zachary J. Schlader, Toby Mündel, Kevin Milne, Earl G. Noble, Felipe Querol, Sofia Pérez-Alenda, José A. Aznar, Stavros Apostolakis, Gregory Y. H. Lip, W. Todd Cade, Kevin E. Yarasheski, Linda S. Pescatello, R. H. Fagard, Fabio Manfredini, Roberto Manfredini, Nancy J. Rehrer, Lawrence E. Armstrong, Gemma A. McLeod, Louise Østergaard, Max Gassmann, Luigi Varesio, Michele Samaja, Michael Vogt, Fabio Breil, Hans Hoppeler   +27 more
  +5 more sources

Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Frontiers in Immunology, 2018
Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms ...
Valentin Schatz, Patrick Neubert, Franz Rieger, Jonathan Jantsch   +3 more
doaj   +1 more source

Hypoxia inducible factor prolyl hydroxylases in inflammatory bowel disease

Frontiers in Pharmacology, 2023
Inflammatory bowel disease (IBD) is a chronic disease that is characterized by intestinal inflammation. Epithelial damage and loss of intestinal barrier function are believed to be the hallmark pathologies of the disease.
Jie Lun, Hongwei Zhang, Jing Guo, Mengchao Yu, Jing Fang   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Regulation of erythropoiesis by hypoxia-inducible factors [PDF]

Blood Reviews, 2013
A classic physiologic response to systemic hypoxia is the increase in red blood cell production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type specific gene expression changes that result in increased erythropoietin (EPO) production in kidney and liver, in enhanced iron uptake and utilization and in adjustments of the
openaire   +2 more sources