Results 71 to 80 of about 4,288,026 (254)

Research advances on hypoxia inducible factor and diabetic nephropathy

Linchuang shenzangbing zazhi
As one of the major microvascular complications of diabetes, diabetic kidney disease (DKD) is one of the major causes of end-stage renal disease (ESRD).
Ye-ping Ma, Zhong-xin. Li
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Hypoxia inducible factors in hepatocellular carcinoma

Oncotarget, 2017
Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors. In this review, we describe the current understanding of hypoxia signaling pathway and summarize the expression, function and target genes of ...
Chen, Chu, Lou, Tao
openaire   +3 more sources

Hypoxic transcription gene profiles under the modulation of nitric oxide in nuclear run on-microarray and proteomics [PDF]

, 2009
Background: Microarray analysis still remains a powerful tool to identify new components of the transcriptosome and it has helped to increase the knowledge of targets triggered by stress conditions such as hypoxia and nitric oxide.
Nathalie Dehne, Bernhard Brüne, Essler, Silke, Igwe, Emeka I., Silke Essler, Natalie Al-Furoukh, Igwe, Emeka I, Igwe Emeka I, Dehne, Nathalie, Essler Silke, Dehne Nathalie, Emeka I Igwe, Brüne, Bernhard, Al-Furoukh Natalie, Al-Furoukh, Natalie, Al-Furoukh, Natalie,, Brüne Bernhard   +16 more
core   +1 more source

Hypoxia induces oncogene yes-associated protein 1 nuclear translocation to promote pancreatic ductal adenocarcinoma invasion via epithelial–mesenchymal transition

Tumor Biology, 2017
Pancreatic ductal adenocarcinoma is one of the most lethal cancers. The Hippo pathway is involved in tumorigenesis and remodeling of tumor microenvironments.
Honglong Wei, Zongzhen Xu, Feng Liu, Fuhai Wang, Xin Wang, Xueying Sun, Jie Li   +6 more
doaj   +1 more source

Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Frontiers in Immunology, 2018
Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms ...
Valentin Schatz, Patrick Neubert, Franz Rieger, Jonathan Jantsch   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Hypoxia Inducible Factor-2α in Cancer [PDF]

Cell Cycle, 2007
Poorly oxygenated (hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels.
Tobias, Löfstedt, Erik, Fredlund, Linda, Holmquist-Mengelbier, Alexander, Pietras, Marie, Ovenberger, Lorenz, Poellinger, Sven, Påhlman   +6 more
openaire   +2 more sources

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +1 more source

Hypoxia-Inducible Factors [PDF]

RCSB Protein Data Bank, 2019
Robert L. Sainburg, Andrew L. Clark, George E. Billman, Zachary J. Schlader, Toby Mündel, Kevin Milne, Earl G. Noble, Felipe Querol, Sofia Pérez-Alenda, José A. Aznar, Stavros Apostolakis, Gregory Y. H. Lip, W. Todd Cade, Kevin E. Yarasheski, Linda S. Pescatello, R. H. Fagard, Fabio Manfredini, Roberto Manfredini, Nancy J. Rehrer, Lawrence E. Armstrong, Gemma A. McLeod, Louise Østergaard, Max Gassmann, Luigi Varesio, Michele Samaja, Michael Vogt, Fabio Breil, Hans Hoppeler   +27 more
  +5 more sources