Results 81 to 90 of about 4,288,026 (254)

Hypoxia-inducible factor-1 alpha expression in endometriosis: A retrospective observational case–control study of ovarian cyst capsules and endometrial tissue samples

Journal of International Medical Research
Background This study aimed to compare the expression patterns of hypoxia-inducible factor-1α in ovarian cyst capsules and endometrial tissue samples from patients with and without endometriosis to evaluate its potential as a biomarker of hypoxia in ...
Ezgi Tolu Cenk, Ceyda Sancakli Usta, Akin Usta, Gulay Turan, Gurhan Guney, Selim Afsar, Mine Islimye Taskin   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Hypoxia and hypoxia-inducible factors in neuroblastoma [PDF]

Cell and Tissue Research, 2017
Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.
Påhlman, Sven, Mohlin, Sofie
openaire   +2 more sources

Cezanne regulates E2F1-dependent HIF2α expression [PDF]

, 2015
Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF).
Bremm, A., Moniz, Sonia, Komander, David, Bremm, Anja, Campbell, K.J., Campbell, Kirsteen J., Campbell, Kirsteen J, Moniz, S., Biddlestone, John, Komander, D., Rocha, S., Bandarra, D., Biddlestone, J., Bandarra, Daniel, Rocha, Sonia   +14 more
core   +1 more source

Arming vaccinia virus for pancreatic cancer oncolytic virotherapy [PDF]

, 2011
PhDVaccinia virus is a 250-300nm enveloped DNA virus from the poxvirus family and is used as a vector for oncolytic viral gene therapy. No unique cell surface receptor has been identified for Vaccinia virus and the reasons for its tropism for cancer ...
Hiley, Crispin
core   +4 more sources

Expression of aldehyde dehydrogenase after neoadjuvant chemotherapy is associated with expression of hypoxia-inducible factors 1 and 2 alpha and predicts prognosis in locally advanced breast cancer

Clinics, 2013
OBJECTIVE: To analyze the expression of hypoxia-inducible factors (hypoxia-inducible factor 1A and hypoxia-inducible factor 2A) and aldehyde dehydrogenase proteins in patients with locally advanced breast carcinoma who were subjected to neoadjuvant ...
Daniel Guimarães Tiezzi, Willian Simões Clagnan, Larissa Raquel Mouro Mandarano, Christiani Bisinoto de Sousa, Heitor Ricardo Cosiski Marana, Marcelo Guimarães Tiezzi, Jurandyr Moreira de Andrade   +6 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Hypoxia-Inducible Factors in Physiology and Medicine [PDF]

Cell, 2012
Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Hypoxia-inducible factor-2α but not hypoxia-inducible factor-1α increases iron traffic in astrocytes [PDF]

, 2020
Abstract Background: Disrupted iron homeostasis in the substantia nigra (SN) is an important mechanism in Parkinson’s disease (PD). In our previous studies using cultured neurons, we showed that 6-hydroxydopamine (6-OHDA) treatment increased the expression of divalent metal transporter-1 (DMT1) gating iron influx and decreased the expression of
Manman Xu, Zhiqiang Chen, Xizhen Ma, Hangrui Xu, Changsheng Fan, Jun Wang, Junxia Xie   +6 more
openaire   +2 more sources