Results 101 to 110 of about 185,754 (313)

The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

Genes and Diseases, 2017
Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes.
Xiu Lv, Jincheng Li, Chuhong Zhang, Tian Hu, Sai Li, Sha He, Hanxing Yan, Yixi Tan, Mingsheng Lei, Meiling Wen, Jianhong Zuo   +10 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Hypoxia-inducible factor 1 alpha in oral squamous cell carcinoma and its relation to prognosis [PDF]

, 2009
The aim of this study was to investigate the correlation between the expression of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and proliferative activity in tumor cells, lymph node metastasis, as well as prognosis in patients with oral squamous cell ...
Uehara, Masataka, Asahina, Izumi, Izumi Asahina, Mihoko Nonaka, Ikeda, Hisazumi, Sano, Kazuo, Masataka Uehara, Nonaka, Mihoko, Hisazumi Ikeda, Kazuo Sano   +9 more
core   +1 more source

Intermittent hypoxic stimulation promotes efficient expression of Hypoxia-inducible factor-1α and exerts a chondroprotective effect in an animal osteoarthritis model.

PLoS ONE
Hypoxia-inducible factor-1α plays an important role in the homeostasis of articular cartilage in hypoxic environments. Therefore, modulation of hypoxia-inducible factor-1α by regulating the oxygen environment could be a useful treatment for ...
Ryota Cha, Shuji Nakagawa, Yuji Arai, Atsuo Inoue, Naoki Okubo, Yuta Fujii, Kenta Kaihara, Kei Nakamura, Tsunao Kishida, Osam Mazda, Kenji Takahashi   +10 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery

, 2008
Background: Several human pathologies, including neoplasia and ischemic cardiovascular diseases, course with an unbalance between oxygen supply and demand ( hypoxia).
Alcaide-German, ML, Del Peso, L, Garcia-Fernandez, LF, Vara-Vega, A, Landazuri, MO   +4 more
core  

Hypoxia-Inducible Factors in Physiology and Medicine [PDF]

Cell, 2012
Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs
openaire   +2 more sources

Hypoxia-inducible factor in breast cancer: role and target for breast cancer treatment

Frontiers in Immunology
Globally, breast cancer stands as the most prevalent form of cancer among women. The tumor microenvironment of breast cancer often exhibits hypoxia. Hypoxia-inducible factor 1-alpha, a transcription factor, is found to be overexpressed and activated in ...
Shijiao Zhi, Chen Chen, Hanlin Huang, Zhengfu Zhang, Fancai Zeng, Shujun Zhang   +5 more
doaj   +1 more source

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Hypoxia-Inducible Factor-1 (HIF-1)-Active Cells as a Target for Cancer Therapy

Journal of Pharmacological Sciences, 2011
The microenvironment of solid tumors is characterized by low pO2 that is well below physiological levels. Intratumoral hypoxia is a major factor contributing to cancer progression and is exacerbated as a result of oxygen consumption by rapidly ...
Shinae Kizaka-Kondoh, Takahiro Kuchimaru, Tetsuya Kadonosono   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source