Results 121 to 130 of about 4,288,026 (254)

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis

Cellular & Molecular Biology Letters
Background Glucocorticoids (GCs) are key regulators of hematopoiesis, but the effects of chronically elevated endogenous GC levels on hematopoietic stem cell (HSC) function and immune cell development remain poorly understood.
Deepika Watts, Nicolas Eberz, Mangesh T. Jaykar, Anupam Sinha, Cagdas Ermis, Johanna Tiebel, Ulrike Baschant, Martina Rauner, Tatyana Grinenko, Triantafyllos Chavakis, Peter Mirtschink, Ali El-Armouche, Ben Wielockx   +12 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Biochemistry of the hypoxia-inducible factor hydroxylases

Current Opinion in Chemical Biology
The hypoxia-inducible factors are α,β-heterodimeric transcription factors that mediate the chronic response to hypoxia in humans and other animals. Protein hydroxylases belonging to two different structural subfamilies of the Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase superfamily modify HIFα. HIFα prolyl-hydroxylation, as catalysed by the PHDs,
Giorgia Fiorini, Christopher J. Schofield   +1 more
openaire   +2 more sources

Investigation of hypoxia-inducible factor-1α in hippocampal sclerosis: A postmortem study

, 2012
Purpose: Hypoxia-inducible factor-1α (HIF-1α) is involved in critical aspects of cell survival in response to hypoxia and regulates vascular endothelial growth factor (VEGF) expression.
Martinian, L., Liu, J.Y.W., Catarino, C.B., Sisodiya, S.M., Feast, A., Thom, M.   +5 more
core   +1 more source

Design and Synthesis of Small-molecule Inhibitors of the Hypoxia Inducible Factor-1 as Anticancer Therapeutics [PDF]

, 2016
Throughout history, cancer has been severely plaguing mankind; the search for a A cure for cancer has long been sought by scientists and still poses as one of the greatest challenges scientists have yet to overcome.
De Los Santos, Zeus Allen O.
core   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Expression of hypoxia-inducible factor-1α in human periodontal tissue

, 2011
Background: Hypoxia-inducible factor (HIF)-1 is a key transcription factor responding to hypoxia. It is composed of an oxygen-sensitive α subunit (HIF-1α) and a constitutively expressed β subunit.
George L. Tipoe, Ng, KM, Jing-Ping Li, Man-Lung Fung, Leung, WK, Kwong Man Ng, Li, JP, Fung, ML, W. Keung Leung, Tipoe, GL, King-Tung Ng, Ng, KT   +11 more
core   +1 more source

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]

, 2014
The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm, Moniz, Sonia, David Komander, Bremm, Anja, Komander, David, Sonia Rocha, Mader, Julia, Rocha, Sonia, Sonia Moniz, Julia Mader   +9 more
core   +1 more source

Transcriptome analysis of goat adipose tissue-derived mesenchymal stem cells cultured in variable oxygen conditions

Frontiers in Cell and Developmental Biology
IntroductionOxygen tension influences mesenchymal stem cell biology, but the transcriptional responses of goat adipose tissue-derived mesenchymal stem cells (gADSCs) to different oxygen-exposure conditions remain incompletely understood.MethodsRNA ...
Utkarsha Vishwakarma, Utkarsha Vishwakarma, Michelle Abraham, Ibraz Kori, Ibraz Kori, Aakash Chawade, Sandeep Kumar Kushwaha, Sandeep Kumar Kushwaha, Sandeep Goel, Sandeep Goel   +9 more
doaj   +1 more source