Results 131 to 140 of about 1,590,992 (346)

The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

Genes and Diseases, 2017
Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes.
Xiu Lv, Jincheng Li, Chuhong Zhang, Tian Hu, Sai Li, Sha He, Hanxing Yan, Yixi Tan, Mingsheng Lei, Meiling Wen, Jianhong Zuo   +10 more
doaj   +1 more source

Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment. [PDF]

, 2019
Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment.
Fan, Li, Feng, Jianbo, Fu, Haijuan, Li, Guiyuan, Li, Peiyao, Liu, Changhong, Liu, Qiang, Liu, Qing, Ren, Xing, She, Xiaoling, Sun, Yingnan, Wu, Minghua, Zhang, Yan, Zhao, Chunhua   +13 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

Genes & Development, 2000
The switch to an angiogenic phenotype is a fundamental determinant of neoplastic growth and tumor progression. We demonstrate that homozygous deletion of the p53 tumor suppressor gene via homologous recombination in a human cancer cell line promotes the ...
R. Ravi, B. Mookerjee, Z. Bhujwalla, C. H. Sutter, D. Artemov, Qinwen Zeng, L. Dillehay, A. Madan, G. Semenza, A. Bedi   +9 more
semanticscholar   +1 more source

Hypoxia-inducible factors in the kidney [PDF]

American Journal of Physiology-Renal Physiology, 2006
Tissue hypoxia not only occurs under pathological conditions but is also an important microenvironmental factor that is critical for normal embryonic development. Hypoxia-inducible factors HIF-1 and HIF-2 are oxygen-sensitive basic helix-loop-helix transcription factors, which regulate biological processes that facilitate both oxygen delivery and ...
openaire   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Hypoxia-inducible factor 1α inhibitor reduces hippocampal neuronal ferroptosis

Neural Regeneration Research
Epilepsy is a prevalent neurological disorder in which hippocampal neuronal damage, particularly ferroptosis, plays a critical role. Previous studies have shown that hypoxia-inducible factor 1α is considered an important regulator of cellular stress ...
Zhen Liang, Qi Guo, Zhaoshi Zheng, Yingyue Lou, Xiaojuan Zhu, Songyan Liu   +5 more
doaj   +1 more source

Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?

Mediators of Inflammation, 2015
Oxygen homeostasis reflects the constant body requirement to generate energy. Hypoxia (0.1–1% O2), physioxia or physoxia (∼1–13%), and normoxia (∼20%) are terms used to define oxygen concentration in the cellular environment.
H. Kumar, D. Choi
semanticscholar   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Hypoxia-Inducible Factor as an Angiogenic Master Switch

Frontiers in Pediatrics, 2015
Hypoxia-inducible factors (HIFs) regulate the transcription of genes that mediate the response to hypoxia. HIFs are constantly expressed and degraded under normoxia, but stabilized under hypoxia.
T. Hashimoto, F. Shibasaki
semanticscholar   +1 more source