Results 61 to 70 of about 4,288,026 (254)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Green Dixy E, Ihnat Michael A, Green, Dixy E., Satyendra S Shenoy, Shenoy Satyendra S, Green DE, Thorpe JE, Ceriello Antonio, Kamat CD, Ceriello, Antonio, Antonio Ceriello, Shenoy, Satyendra S, Dixy E Green, Kamat Chandrashekhar D, Linda A Warnke, Warnke, Linda A., Warnke Linda A, Shenoy SS, Chandrashekhar D Kamat, Michael A Ihnat, Warnke LA, Kamat, Chandrashekhar D., Ihnat, Michael A., Ihnat M.A., Thorpe, Jessica E, Thorpe Jessica E, Jessica E Thorpe   +26 more
core   +2 more sources

Effect of low-frequency low-intensity ultrasound with microbubbles on prostate cancer hypoxia

Tumor Biology, 2017
Angiogenesis plays an important role in tumor growth, invasiveness, and metastasis. It is well established that prostate cancer is exposed to fluctuating oxygen tensions and both acute and chronic hypoxia exist, and these conditions can upregulate ...
Rui Hou, Yanjun Xu, Qijie Lu, Yang Zhang, Bing Hu   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Regulation of erythropoiesis by hypoxia-inducible factors [PDF]

Blood Reviews, 2013
A classic physiologic response to systemic hypoxia is the increase in red blood cell production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type specific gene expression changes that result in increased erythropoietin (EPO) production in kidney and liver, in enhanced iron uptake and utilization and in adjustments of the
openaire   +2 more sources

Hypoxia helps glioma to fight therapy [PDF]

, 2009
Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena, V Amberger-Murphy   +1 more
core   +2 more sources

Roxadustat, a HIF-PHD inhibitor with exploitable potential on diabetes-related complications

Frontiers in Pharmacology, 2023
Diabetes mellitus (DM) is a group of metabolic diseases caused by absolute or relative deficiency of insulin secretion and characterized by chronic hyperglycemia.
Tingting Fang, Congcong Ma, Zhanming Zhang, Luning Sun, Ningning Zheng   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Endocrine targets of hypoxia-inducible factors [PDF]

Journal of Endocrinology, 2017
Endocrine is an important and tightly regulated system for maintaining body homeostasis. Endocrine glands produce hormones, which are released into blood stream to guide the target cells responding to all sorts of stimulations. For maintaining body homeostasis, the secretion and activity of a particular hormone needs to be adjusted in responding to ...
Hsiu-Chi, Lee, Shaw-Jenq, Tsai
openaire   +2 more sources

CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes [PDF]

, 2014
Standard culture of human induced pluripotent stem cells (hiPSCs) requires basic Fibroblast Growth Factor (bFGF) to maintain the pluripotent state, whereas hiPSC more closely resemble epiblast stem cells than true naïve state ES which requires LIF to ...
Tang, D, Suzuki, H., Forrest, Alistair R. R., Hasegawa, Y., Suzuki, H, Ovchinnikov, Dmitry A., Hitchens, Kelly J., Takahashi, N., Forrest, A.R.R., Kenna, Tony, Suzuki, Harukazu, Tang, D., Joshi, Anagha, Hayashizaki, Y., Wolvetang, Ernst, Tang, Dave, Suzuki, H., Forrest, Alistair R R, FANTOM Consortium, the FANTOM consortium, Vijayan, Dipti, Wells, Christine A., Hasegawa, Y, Hayashizaki, Yoshihide, Forrest, ARR, Takahashi, Naoko, Briggs, James, Hasegawa, Yuki, Blumenthal, Antje, Tang, D., Hayashizaki, Y, ?, ?, Sajantila, Antti, Hasegawa, Y., Takahashi, N, Takahashi, N., Forrest, A. R., Beckhouse, Anthony G., FANTOM Consortium,, Hayashizaki, Y.   +39 more
core   +1 more source