Results 11 to 20 of about 4,288,026 (254)

Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis

Clinical and Experimental Gastroenterology, 2014
Ram Gupta,1 Anita R Chaudhary,2 Binita N Shah,1 Avinash V Jadhav,3 Shitalkumar P Zambad,1 Ramesh Chandra Gupta,4 Shailesh Deshpande,4 Vijay Chauthaiwale,4 Chaitanya Dutt4 1Department of Pharmacology, 2Cellular and Molecular Biology, 3Preclinical Safety ...
Gupta R, Chaudhary AR, Shah BN, Jadhav AV, Zambad SP, Gupta RC, Deshpande S, Chauthaiwale V, Dutt C   +8 more
doaj   +1 more source

Hypoxia-Inducible Factors and Cancer [PDF]

Current Sleep Medicine Reports, 2017
Hypoxia inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell ...
Jonathan C, Jun, Aman, Rathore, Haris, Younas, Daniele, Gilkes, Vsevolod Y, Polotsky   +4 more
openaire   +2 more sources

Microarray analysis of pathways involved in bladder cancer invasion and metastasis. [PDF]

, 2008
MDHypoxia-inducible genes have been linked to the aggressive phenotype of cancer. However, nearly all work on hypoxia-regulated genes has been conducted in vitro on cell lines.
Ord, Jonathan J
core   +4 more sources

Hypoxia-Inducible Factor in Thyroid Carcinoma [PDF]

Journal of Thyroid Research, 2011
Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy.
Burrows, Natalie, Babur, Muhammad, Resch, Julia, Williams, Kaye J, Brabant, Georg   +4 more
openaire   +3 more sources

The human side of hypoxia‐inducible factor [PDF]

British Journal of Haematology, 2008
SummaryWhen humans are exposed to hypoxia, systemic and intracellular changes operate together to minimise hypoxic injury and restore adequate oxygenation. Emerging evidence indicates that the hypoxia‐inducible factor (HIF) family of transcription factors plays a central regulatory role in these homeostatic changes at both the systemic and cellular ...
Smith, T, Robbins, P, Ratcliffe, P
openaire   +3 more sources

Hypoxia-inducible factors and diabetes [PDF]

Journal of Clinical Investigation, 2020
Hypoxia can be defined as a relative deficiency in the amount of oxygen reaching the tissues. Hypoxia-inducible factors (HIFs) are critical regulators of the mammalian response to hypoxia. In normal circumstances, HIF-1α protein turnover is rapid, and hyperglycemia further destabilizes the protein.
openaire   +2 more sources

Advances in Hypoxia-Inducible Factor Biology [PDF]

Cell Metabolism, 2018
Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis and metabolic activation. Beyond this, HIF influences many other processes. Hypoxia, in part through HIF-dependent mechanisms, influences epigenetic factors, including DNA methylation ...
Choudhry, H, Harris, A
openaire   +3 more sources

Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens [PDF]

, 2010
Background: Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases ...
Peschel, Andreas, Edelmann, Markus, Schäfer, Andrea, Werth Nadine, Andreas Peschel, Volkhard A. J. Kempf, Edelmann Markus, Yazdi Amir S., Becker, Karsten, Rosenberger, Christian, Nadine Werth, Amir S Yazdi, Volkhard A J Kempf, Bernhardt Wanja, Kempf, Volkhard A. J., Amr, Amro, Rosenberger Christian, Amr Amro, Werth, Nadine, Andrea Schäfer, Peschel Andreas, von Eiff Christof, Christiane Beerlage, Kempf Volkhard A. J., Eiff, Christof von, Amro Amr, Becker Karsten, Beerlage, Christiane, Christof von Eiff, Wanja Bernhardt, Yazdi, Amir Sadegh, Bernhardt, Wanja, Christian Rosenberger, Karsten Becker, Schäfer Andrea, Beerlage Christiane, Amir S. Yazdi, Markus Edelmann   +37 more
core   +2 more sources

SnapShot: Hypoxia-Inducible Factors

Cell, 2015
Molecular oxygen (O2) is a key substrate for mitochondrial ATP production and numerous intracellular biochemical reactions. The maintenance of O2 homeostasis is therefore essential for the survival of most species. During O2 deprivation, mammalian cells rely on multiple adaptations mediated by the hypoxia-inducible factors (HIFs), mTOR, autophagy, and ...
Lee, Kyoung Eun, Simon, M. Celeste
openaire   +2 more sources

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK, Wann, Angus K.T., Chapple, JP, Knight, MM, Knight, Martin M., Thompson, CL, Thompson, Clare L., Chapple, J. Paul   +7 more
core   +1 more source