Hypoxia-Inducible Factor-1 [PDF]
Definitions, 2020 Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia.
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Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis [PDF]
Cellular & Molecular Biology LettersBackground Glucocorticoids (GCs) are key regulators of hematopoiesis, but the effects of chronically elevated endogenous GC levels on hematopoietic stem cell (HSC) function and immune cell development remain poorly understood.
Deepika Watts +12 more
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Hypoxia-inducible factor-1 alpha expression in endometriosis: A retrospective observational case–control study of ovarian cyst capsules and endometrial tissue samples [PDF]
Journal of International Medical ResearchBackground This study aimed to compare the expression patterns of hypoxia-inducible factor-1α in ovarian cyst capsules and endometrial tissue samples from patients with and without endometriosis to evaluate its potential as a biomarker of hypoxia in ...
Ezgi Tolu Cenk +6 more
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Advances in Hypoxia-Inducible Factor Biology. [PDF]
Cell Metabolism, 2017 Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis and metabolic activation. Beyond this, HIF influences many other processes. Hypoxia, in part through HIF-dependent mechanisms, influences epigenetic factors, including DNA methylation ...
Hani Choudhry, A. Harris
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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Cell, 2011 W. Luo +8 more
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Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines
Cells, 2021 Hypoxia and inflammation are frequently co-incidental features of the tissue microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on inflammatory pathways in immune cells has been well characterized, less is known about ...
Mykyta I Malkov, Chee T. Lee, C. Taylor
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Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. [PDF]
PLoS ONE, 2017 Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible ...
Veronika Bäcker +4 more
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Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Cell, 2011 E. Dang +17 more
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Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology
Journal of Physiology, 2020 Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP levels.
S. J. Kierans, C. Taylor
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Cells, 2021 Hypoxia-inducible factor 1 can sufficiently control the progress of neurological symptoms after ischemic stroke owing to their actions associated with its downstream genes.
Nashwa Amin +10 more
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