Results 11 to 20 of about 139,280 (119)

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

Haematologica, 2012
Background Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected.
Maria Mastrogiannaki, Pavle Matak, Jacques R.R. Mathieu, Stéphanie Delga, Patrick Mayeux, Sophie Vaulont, Carole Peyssonnaux   +6 more
doaj   +1 more source

Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells

Haematologica, 2010
Background Multiple myeloma is an incurable malignancy of bone marrow plasma cells. Progression of multiple myeloma is accompanied by an increase in bone marrow angiogenesis.
Sally K. Martin, Peter Diamond, Sharon A. Williams, Luen Bik To, Daniel J. Peet, Nobutaka Fujii, Stan Gronthos, Adrian L. Harris, Andrew C.W. Zannettino   +8 more
doaj   +1 more source

Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1

Molecules, 2018
Induction of a series of anti-hypoxic proteins protects cells during exposure to hypoxic conditions. Hypoxia-inducible factor-α (HIF-α) is a major transcription factor that orchestrates this protective effect.
Shin-ichi Kawaguchi, Yuhei Gonda, Takuya Yamamoto, Yuki Sato, Hiroyuki Shinohara, Yohsuke Kobiki, Atsuhiko Ichimura, Takashi Dan, Motohiro Sonoda, Toshio Miyata, Akiya Ogawa, Tadayuki Tsujita   +11 more
doaj   +1 more source

Roxadustat: Not just for anemia

Frontiers in Pharmacology, 2022
Roxadustat is a recently approved hypoxia-inducible factor prolyl hydroxylase inhibitor that has demonstrated favorable safety and efficacy in the treatment of renal anemia.
Xiaoyu Zhu, Lili Jiang, Xuejiao Wei, Mengtuan Long, Yujun Du   +4 more
doaj   +1 more source

Bortezomib and metformin opposingly regulate the expression of hypoxia-inducible factor alpha and the consequent development of chemotherapy-induced painful peripheral neuropathy

Molecular Pain, 2019
Chemotherapy-induced painful peripheral neuropathy is a significant clinical problem that is associated with widely used chemotherapeutics. Unfortunately, the molecular mechanisms by which chemotherapy-induced painful peripheral neuropathy develops have ...
Taylor Ludman, Ohannes K Melemedjian
doaj   +1 more source

Compound C prevents Hypoxia-Inducible Factor-1α protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I

BMC Research Notes, 2011
The transcription factor Hypoxia-Inducible Factor-1α is a master regulator of the cellular response to low oxygen concentration. Compound C, an inhibitor of AMP-activated kinase, has been reported to inhibit hypoxia dependent Hypoxia-Inducible Factor-1α ...
Hagen Thilo, Chua Yee Liu
doaj   +1 more source

A Comprehensive Review on Environmental and Microenvironmental Oxygen Sensing Pathways Mediated by Hypoxia-Inducible Factors (HIFs)

مجله دانشکده پزشکی اصفهان, 2019
Oxygen deficiency, referred to as hypoxia, can be divided into two categories of environmental (exogenous) which is sensitized by respiratory cells, and microenvironmental (endogenous) responses by other cells in the body, like cancer cells.
Fatemeh Choopani, Ali Choopani, Mahmood Tavallaei, Nasrin Kariminejad, Houri Edalat   +4 more
doaj   +1 more source

SIRT3 inhibition suppresses hypoxia‐inducible factor 1α signaling and alleviates hypoxia‐induced apoptosis of type B spermatogonia GC‐2 cells

FEBS Open Bio, 2023
Hypoxia has been reported to be an important factor leading to male infertility, and it has been reported that hypoxia can induce the apoptosis of mouse spermatogenic cells.
Zixuan Wang, Chunchun Zhu, Yangyang Song, Xiaoyun Chen, Jie Zheng, Lian He, Xing Liu, Zhu Chen   +7 more
doaj   +1 more source

Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats

Neural Regeneration Research, 2021
Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains.
Qiu-Shi Gao, Ya-Han Zhang, Hang Xue, Zi-Yi Wu, Chang Li, Ping Zhao   +5 more
doaj   +1 more source

Peculiarities of expression of HIF-1Α and HIF-3Α in hypothalamus of Wistar rats under the influence of intermittent hypobaric hypoxia

Patologìâ, 2017
The purpose of this study was to establish the features of the expression of hif‑1α and hif-3α genes and the accumulation of HIF-1α and HIF-3α proteins in the paraventricular (PVH) and supraoptic (SO) nuclei of the hypothalamus under the conditions of ...
A. V. Abramov, V. A. Shamenko
doaj   +1 more source