Results 31 to 40 of about 180,302 (314)

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells [PDF]

, 2013
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors.
Court, William, Cuda, F., Eccles, Suzanne A., Fox, Keith R., Hoakwie, Franciane, Lawrence, Charlotte, Male, Abigail, Miranda, Elena, Nordgren, Ida, Packham, Graham K., Tavassoli, Ali, Townsend, Paul   +11 more
core   +1 more source

Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition

Tumor Biology, 2017
Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma by activating the key transcription factor, hypoxia-inducible factor-1.
Ming Ye, Zejun Fang, Hongqian Gu, Rui Song, Jiangwei Ye, Hongzhang Li, Zhiguang Wu, Shenghui Zhou, Peng Li, Xiang Cai, Xiaokun Ding, Songshan Yu   +11 more
doaj   +1 more source

Ekspresi Hypoxia-Inducible Factor-1α menginduksi Ekspresi Eritropoietin Intraseluler, dan Vascular Endothelial Growth Factor pada Penderita Kanker Payudara dengan Anemia

Jurnal Kedokteran Brawijaya, 2013
 Anemia merupakan faktor prognostik independen untuk pertahanan hidup pasien kanker. Penurunan kapasitas oksigen pada darah dapat menyebabkan terjadinya kondisi hipoksia pada jaringan kanker . Hipoksia pada jaringan kanker dapat mengaktivasi faktor transkripsi hypoxia-inducible factor-1α (HIF-1α) yang kemudian akan mentranskripsi banyak gen lain ...
Muhammad Darwin P, Handono Kalim, Djoko Wahono S, Aru W Sudoyo, Fatchiyah Fatchiyah   +4 more
openaire   +2 more sources

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Cells, 2020
Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy.
M. Alique, E. Sanchez-Lopez, G. Bodega, C. Giannarelli, J. Carracedo, R. Ramírez   +5 more
semanticscholar   +1 more source

Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells [PDF]

International Neurourology Journal, 2019
Purpose Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain.
Seung-Yeon Yoo, Ji-Young Yoo, Han-Byeol Kim, Tai-Kyoung Baik, Jun-Ho Lee, Ran-Sook Woo   +5 more
doaj   +1 more source

Repurposing Combination Therapy of Voacamine With Vincristine for Downregulation of Hypoxia-Inducible Factor-1α/Fatty Acid Synthase Co-axis and Prolyl Hydroxylase-2 Activation in ER+ Mammary Neoplasia

Frontiers in Cell and Developmental Biology, 2021
The current study investigated the role of combination therapy with voacamine and vincristine in preventing mammary gland carcinoma through prolyl hydroxylase-2 activation.
Lakhveer Singh, Subhadeep Roy, Anurag Kumar, Shubham Rastogi, Dinesh Kumar, Mohd. Nazam Ansari, Abdulaziz S. Saeedan, Manjari Singh, Gaurav Kaithwas   +8 more
doaj   +1 more source

A novel inhibitor of hypoxia-inducible factor-1α P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells [PDF]

, 2011
Background Hypoxia-inducible factor-1 (HIF-1) is a master regulator of the transcriptional response to hypoxia. It is essential for angiogenesis and is associated with tumor progression and overexpression of HIF-1α has been demonstrated in ...
Sonal M Manohar, Amol A Padgaonkar, Archana Jalota-Badhwar, Vinay Sonawane, Maggie J Rathos, Sanjay Kumar, Kalpana S Joshi   +6 more
core   +1 more source

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +3 more sources

PCAT-1 facilitates breast cancer progression via binding to RACK1 and enhancing oxygen-independent stability of HIF-1α

Molecular Therapy: Nucleic Acids, 2021
Hypoxia induces a series of cellular adaptive responses that enable promotion of inflammation and cancer development. Hypoxia-inducible factor-1α (HIF-1α) is involved in the hypoxia response and cancer promotion, and it accumulates in hypoxia and is ...
Jianlong Wang, Xuyi Chen, Haijuan Hu, Mengting Yao, Yanbiao Song, Aimin Yang, Xiuhua Xu, Ning Zhang, Jianzhao Gao, Bin Liu   +9 more
doaj   +1 more source

Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner [PDF]

, 2018
17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain ...
Albrecht, Marjorie, Frump, Andrea L., Lahm, Tim, Petrache, Irina, Selej, Mona, Wood, Jordan A., Yakubov, Bakhtiyor   +6 more
core   +1 more source