Results 51 to 60 of about 4,389,282 (265)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Impairment of HIF-1α-mediated metabolic adaption by NRF2-silencing in breast cancer cells

Redox Biology, 2019
Hypoxia, a common element in the tumor environment, leads to Hypoxia-Inducible Factor-1α (HIF-1α) stabilization to modulate cellular metabolism as an adaptive response. In a previous study, we showed that inhibition of the nuclear factor erythroid 2-like-
Sujin Lee, Steffanus Pranoto Hallis, Kyeong-Ah Jung, Dayoung Ryu, Mi-Kyoung Kwak   +4 more
doaj   +1 more source

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Green Dixy E, Ihnat Michael A, Green, Dixy E., Satyendra S Shenoy, Shenoy Satyendra S, Green DE, Thorpe JE, Ceriello Antonio, Kamat CD, Ceriello, Antonio, Antonio Ceriello, Shenoy, Satyendra S, Dixy E Green, Kamat Chandrashekhar D, Linda A Warnke, Warnke, Linda A., Warnke Linda A, Shenoy SS, Chandrashekhar D Kamat, Michael A Ihnat, Warnke LA, Kamat, Chandrashekhar D., Ihnat, Michael A., Ihnat M.A., Thorpe, Jessica E, Thorpe Jessica E, Jessica E Thorpe   +26 more
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions

SAGE Open Medicine, 2016
Introduction: We evaluated the association between two single nucleotide polymorphisms of the vascular endothelial growth factor gene and one of the hypoxia-inducible factor-1α gene and the degree of coronary collateral formation in patients with a ...
Vincent Amoah, Benjamin Wrigley, Eric Holroyd, Andrew Smallwood, Angel L Armesilla, Alan Nevill, James Cotton   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

SCF, regulated by HIF-1α, promotes pancreatic ductal adenocarcinoma cell progression.

PLoS ONE, 2015
Stem cell factor (SCF) and hypoxia-inducible factor-1α (HIF-1α) both have important functions in pancreatic ductal adenocarcinoma (PDAC). This study aims to analyze the expression and clinicopathological significance of SCF and HIF-1α in PDAC specimens ...
Chuntao Gao, Shasha Li, Tiansuo Zhao, Jing Chen, He Ren, Huan Zhang, Xiuchao Wang, Mingxiao Lang, Jingcheng Liu, Song Gao, Xiao Zhao, Jun Sheng, Zhanna Yuan, Jihui Hao   +13 more
doaj   +1 more source

Investigation of hypoxia-inducible factor-1α in hippocampal sclerosis: A postmortem study

, 2012
Purpose: Hypoxia-inducible factor-1α (HIF-1α) is involved in critical aspects of cell survival in response to hypoxia and regulates vascular endothelial growth factor (VEGF) expression.
Martinian, L., Liu, J.Y.W., Catarino, C.B., Sisodiya, S.M., Feast, A., Thom, M.   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source