Results 41 to 50 of about 180,302 (314)

Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancer

Cancer Science, 2019
Since the first identification of hypoxic cells in sections of carcinomas in the 1950s, hypoxia has been known as a central hallmark of cancer cells and their microenvironment.
Y. Hayashi, A. Yokota, H. Harada, Gang Huang   +3 more
semanticscholar   +1 more source

Hmox1 (Heme Oxygenase-1) Protects Against Ischemia-Mediated Injury via Stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the degradation of heme to carbon monoxide, iron, and biliverdin.
L. Dunn, S. Kong, S. Tumanov, Weiyu Chen, J. Cantley, Anita Ayer, G. Maghzal, R. G. Midwinter, K. Chan, M. Ng, R. Stocker   +10 more
semanticscholar   +1 more source

Hypoxia up-regulates SERPINB3 through HIF-2\u3b1 in human liver cancer cells. [PDF]

, 2015
SERPINB3 is a cysteine-proteases inhibitor up-regulated in a significant number of cirrhotic patients carrying hepatocellular carcinoma (HCC) and recently proposed as a prognostic marker for HCC early recurrence.
Autelli, Riccardo, Biasiolo, A, Cambieri, I, Cannito, Stefania, Cillo, U, Cillo, U, Colombatto, Sebastiano, David, E, Fasolato, S, Morello, E, Musso, Tiziana, Novo, Erica, Parola, Maurizio, Paternostro, Claudia, Pontisso, P, Quarta, S, Rovida, E, Smedile, Antonina, Turato, C, Tusa, I, Villano, G   +20 more
core   +3 more sources

Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy

Scientific Reports, 2019
Previous studies have demonstrated intrarenal hypoxia in patients with diabetes. Hypoxia-inducible factor (HIF)-1 plays an important role in hypoxia-induced tubulointerstitial fibrosis.
Ryoichi Bessho, Y. Takiyama, Takao Takiyama, Hiroya Kitsunai, Yasutaka Takeda, Hidemitsu Sakagami, Tsuguhito Ota   +6 more
semanticscholar   +1 more source

Depletion of HIF-1α by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia

Cells, 2022
The transcription factor hypoxia-inducible factor (HIF) is the main oxygen sensor which regulates adaptation to cellular hypoxia. The aim of this study was to establish cultured murine hepatocyte derived cells (mHDC) as an in vitro model and to analyze ...
Akram Hamidi, Alexandra Wolf, Rositsa Dueva, Melanie Kaufmann, Kirsten Göpelt, George Iliakis, Eric Metzen   +6 more
doaj   +1 more source

Hypoxia Inducible Factor-1α: The Curator of Gut Homeostasis

Frontiers in Cellular and Infection Microbiology, 2020
The human gut microbiome is a stratified and resilient ecosystem co-inhabited by a diverse and dynamic pool of microorganisms. Microbial selection, establishment, and colonization are modulated through a complex molecular network of host-microbial ...
Tarun Kumar, R. Pandey, N. Chauhan
semanticscholar   +1 more source

Differential expression of hypoxia-inducible factor 1α in non-small cell lung cancer and small cell lung cancer

Clinics, 2012
OBJECTIVES: The aim of this study was to compare the expression of hypoxia-inducible factor 1α and vascular endothelial growth factor in small cell lung cancer and subtypes of non-small cell lung cancer and examine their relationships with ...
Eleni Karetsi, Maria G. Ioannou, Theodora Kerenidi, Markos Minas, Paschalis A. Molyvdas, Konstantinos I. Gourgoulianis, Efrosyni Paraskeva   +6 more
doaj   +1 more source

Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay [PDF]

, 2014
The molecular mechanisms by which glioblastoma multiforme (GBM) refracts and becomes resistant to radiotherapy treatment remains largely unknown. This radioresistance is partly due to the presence of hypoxic regions, which are frequently found in GBM ...
Cerasani, Manuela, Ciccarelli, Carmela, Di Cesare, Ernesto, Di Genova, Daniela, Festuccia, Claudio, Ficorella, Corrado, Fratticci, Amato, Gravina, Giovanni Luca, Mancini, Marta, Marampon, Francesco, Popov, Vladimir M, Zani, Bianca Maria   +11 more
core   +1 more source

Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

Nature Communications, 2018
Hypoxia-inducible factors (HIFs) are key elements for controlling immune cell metabolism and functions. While HIFs are known to be involved in T cells and macrophages activation, their functions in B lymphocytes are poorly defined.
Xianyi Meng, Bettina Grötsch, Yubin Luo, K. Knaup, M. Wiesener, Xiao-xiang Chen, J. Jantsch, S. Fillatreau, G. Schett, A. Bozec   +9 more
semanticscholar   +1 more source

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells.

PLoS ONE, 2011
DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival. Here, we demonstrate that hypoxia inducible factor-1α
Mahendran Botlagunta, Balaji Krishnamachary, Farhad Vesuna, Paul T Winnard, Guus M Bol, Arvind H Patel, Venu Raman   +6 more
doaj   +1 more source