Results 21 to 30 of about 4,389,282 (265)

PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia [PDF]

, 2014
A17 Hypoxia is an important developmental cue for multicellular organisms but it is also a contributing factor for several human pathologies, such as stroke, cardiovascular diseases and cancer.
Michael Batie (681257), Mudie, Sharon, Moniz, Sonia, Sonia Rocha (231588), Sonia Moniz (681259), Ortmann, Brian, Brian Ortmann (681260), Daniel Bandarra (681256), Sharon Mudie (231581), Batie, Michael, Biddlestone, John, Alena Shmakova (681261), Shmakova, Alena, Bandarra, Daniel, John Biddlestone (681258), Rocha, Sonia   +15 more
core   +1 more source

Hypoxia inducible factor 1α, hypoxanthine‐guanine phosphoribolsyl transferase and NADPH oxidase 4 from northern elephant seals: cDNA characterization and tissue expression

The FASEB Journal, 2011
Northern elephant seals ( Mirounga angustirostris ) are naturally adapted to prolonged periods (1–3 months) of food deprivation (fasting) and tissue ischemia. Fasting elephant seal pups do not exhibit signs of oxidative damage or inflammation despite increases in the renin‐angiotensin system,
Jose Guadalupe Sonanez Organis, Jose Pablo Vazquez Medina, Andy Aguilar, Henry Forman, Daniel Crocker, Rudy Ortiz   +5 more
openaire   +1 more source

Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens [PDF]

, 2010
Background: Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases ...
Peschel, Andreas, Edelmann, Markus, Schäfer, Andrea, Werth Nadine, Andreas Peschel, Volkhard A. J. Kempf, Edelmann Markus, Yazdi Amir S., Becker, Karsten, Rosenberger, Christian, Nadine Werth, Amir S Yazdi, Volkhard A J Kempf, Bernhardt Wanja, Kempf, Volkhard A. J., Amr, Amro, Rosenberger Christian, Amr Amro, Werth, Nadine, Andrea Schäfer, Peschel Andreas, von Eiff Christof, Christiane Beerlage, Kempf Volkhard A. J., Eiff, Christof von, Amro Amr, Becker Karsten, Beerlage, Christiane, Christof von Eiff, Wanja Bernhardt, Yazdi, Amir Sadegh, Bernhardt, Wanja, Christian Rosenberger, Karsten Becker, Schäfer Andrea, Beerlage Christiane, Amir S. Yazdi, Markus Edelmann   +37 more
core   +2 more sources

Ginsenoside 20(S)-Rg3 suppresses ovarian cancer migration via hypoxia-inducible factor 1 alpha and nuclear factor-kappa B signals

Tumor Biology, 2017
Hypoxia-inducible factor 1 is believed to play a prominent role in the survival and developing progress of cancers. As a result, inhibiting α subunit of hypoxia-inducible factor 1 represents an attractive strategy against tumor.
Ting Liu, Le Zhao, Huilian Hou, Lu Ding, Wei Chen, Xu Li   +5 more
doaj   +1 more source

Ekspresi Hypoxia-Inducible Factor-1α menginduksi Ekspresi Eritropoietin Intraseluler, dan Vascular Endothelial Growth Factor pada Penderita Kanker Payudara dengan Anemia

Jurnal Kedokteran Brawijaya, 2013
 Anemia merupakan faktor prognostik independen untuk pertahanan hidup pasien kanker. Penurunan kapasitas oksigen pada darah dapat menyebabkan terjadinya kondisi hipoksia pada jaringan kanker . Hipoksia pada jaringan kanker dapat mengaktivasi faktor transkripsi hypoxia-inducible factor-1α (HIF-1α) yang kemudian akan mentranskripsi banyak gen lain ...
Muhammad Darwin P, Handono Kalim, Djoko Wahono S, Aru W Sudoyo, Fatchiyah Fatchiyah   +4 more
openaire   +2 more sources

Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition

Tumor Biology, 2017
Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma by activating the key transcription factor, hypoxia-inducible factor-1.
Ming Ye, Zejun Fang, Hongqian Gu, Rui Song, Jiangwei Ye, Hongzhang Li, Zhiguang Wu, Shenghui Zhou, Peng Li, Xiang Cai, Xiaokun Ding, Songshan Yu   +11 more
doaj   +1 more source

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +1 more source

Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells [PDF]

International Neurourology Journal, 2019
Purpose Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain.
Seung-Yeon Yoo, Ji-Young Yoo, Han-Byeol Kim, Tai-Kyoung Baik, Jun-Ho Lee, Ran-Sook Woo   +5 more
doaj   +1 more source

Repurposing Combination Therapy of Voacamine With Vincristine for Downregulation of Hypoxia-Inducible Factor-1α/Fatty Acid Synthase Co-axis and Prolyl Hydroxylase-2 Activation in ER+ Mammary Neoplasia

Frontiers in Cell and Developmental Biology, 2021
The current study investigated the role of combination therapy with voacamine and vincristine in preventing mammary gland carcinoma through prolyl hydroxylase-2 activation.
Lakhveer Singh, Subhadeep Roy, Anurag Kumar, Shubham Rastogi, Dinesh Kumar, Mohd. Nazam Ansari, Abdulaziz S. Saeedan, Manjari Singh, Gaurav Kaithwas   +8 more
doaj   +1 more source

Dose-dependent effects of Allopurinol on human foreskin fibroblast cell and human umbilical vein endothelial cell under hypoxia [PDF]

, 2015
Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia ...
Sun, Yu, George Jacob, Sun Yu, Yu Sun, Sonia Rocha, Jacob George, George, Jacob, Rocha, Sonia, Rocha Sonia   +8 more
core   +1 more source