Results 21 to 30 of about 122,157 (267)

Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization

Neural Regeneration Research, 2023
Inhibiting retinal neovascularization is the optimal strategy for the treatment of retina-related diseases, but there is currently no effective treatment for retinal neovascularization.
Yong Yu, Li-Kun Xia, Yu Di, Qing-Zhu Nie, Xiao-Long Chen   +4 more
doaj   +1 more source

Hypoxia inducible factor 1α, hypoxanthine‐guanine phosphoribolsyl transferase and NADPH oxidase 4 from northern elephant seals: cDNA characterization and tissue expression

The FASEB Journal, 2011
Northern elephant seals ( Mirounga angustirostris ) are naturally adapted to prolonged periods (1–3 months) of food deprivation (fasting) and tissue ischemia. Fasting elephant seal pups do not exhibit signs of oxidative damage or inflammation despite increases in the renin‐angiotensin system,
Jose Guadalupe Sonanez Organis, Jose Pablo Vazquez Medina, Andy Aguilar, Henry Forman, Daniel Crocker, Rudy Ortiz   +5 more
openaire   +1 more source

Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities [PDF]

, 2014
E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
Dias, David M, Carles Galdeano (1305135), Galdeano, Carles, Dias, David M., David M. Dias (1340694), Van Molle, Inge, Gadd, Morgan Stuart, Ciulli, Alessio, Sarah Hewitt (1340700), Soares, Pedro, Galdeano , Carles, Pedro Soares (393566), Gadd, Morgan S., Salvatore Scaffidi (1340703), Inge Van Molle (1284120), Morgan S. Gadd (149371), Scaffidi, Salvatore, Ipek Birced (1340697), Alessio Ciulli (762789), Hewitt, Sarah, Birced, Ipek   +20 more
core   +1 more source

PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia [PDF]

, 2014
A17 Hypoxia is an important developmental cue for multicellular organisms but it is also a contributing factor for several human pathologies, such as stroke, cardiovascular diseases and cancer.
Michael Batie (681257), Mudie, Sharon, Moniz, Sonia, Sonia Rocha (231588), Sonia Moniz (681259), Ortmann, Brian, Brian Ortmann (681260), Daniel Bandarra (681256), Sharon Mudie (231581), Batie, Michael, Biddlestone, John, Alena Shmakova (681261), Shmakova, Alena, Bandarra, Daniel, John Biddlestone (681258), Rocha, Sonia   +15 more
core   +1 more source

Ginsenoside 20(S)-Rg3 suppresses ovarian cancer migration via hypoxia-inducible factor 1 alpha and nuclear factor-kappa B signals

Tumor Biology, 2017
Hypoxia-inducible factor 1 is believed to play a prominent role in the survival and developing progress of cancers. As a result, inhibiting α subunit of hypoxia-inducible factor 1 represents an attractive strategy against tumor.
Ting Liu, Le Zhao, Huilian Hou, Lu Ding, Wei Chen, Xu Li   +5 more
doaj   +1 more source

Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition

Tumor Biology, 2017
Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma by activating the key transcription factor, hypoxia-inducible factor-1.
Ming Ye, Zejun Fang, Hongqian Gu, Rui Song, Jiangwei Ye, Hongzhang Li, Zhiguang Wu, Shenghui Zhou, Peng Li, Xiang Cai, Xiaokun Ding, Songshan Yu   +11 more
doaj   +1 more source

Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells [PDF]

International Neurourology Journal, 2019
Purpose Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain.
Seung-Yeon Yoo, Ji-Young Yoo, Han-Byeol Kim, Tai-Kyoung Baik, Jun-Ho Lee, Ran-Sook Woo   +5 more
doaj   +1 more source

Repurposing Combination Therapy of Voacamine With Vincristine for Downregulation of Hypoxia-Inducible Factor-1α/Fatty Acid Synthase Co-axis and Prolyl Hydroxylase-2 Activation in ER+ Mammary Neoplasia

Frontiers in Cell and Developmental Biology, 2021
The current study investigated the role of combination therapy with voacamine and vincristine in preventing mammary gland carcinoma through prolyl hydroxylase-2 activation.
Lakhveer Singh, Subhadeep Roy, Anurag Kumar, Shubham Rastogi, Dinesh Kumar, Mohd. Nazam Ansari, Abdulaziz S. Saeedan, Manjari Singh, Gaurav Kaithwas   +8 more
doaj   +1 more source

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +1 more source

PCAT-1 facilitates breast cancer progression via binding to RACK1 and enhancing oxygen-independent stability of HIF-1α

Molecular Therapy: Nucleic Acids, 2021
Hypoxia induces a series of cellular adaptive responses that enable promotion of inflammation and cancer development. Hypoxia-inducible factor-1α (HIF-1α) is involved in the hypoxia response and cancer promotion, and it accumulates in hypoxia and is ...
Jianlong Wang, Xuyi Chen, Haijuan Hu, Mengting Yao, Yanbiao Song, Aimin Yang, Xiuhua Xu, Ning Zhang, Jianzhao Gao, Bin Liu   +9 more
doaj   +1 more source