Results 71 to 80 of about 136,719 (278)
Prx1 regulates HIF-1α expression. [PDF]
, 2013 A. 2H-11 cells were stimulated with 20 nM rPrx1. Total RNA was collected at various times after stimulation and qPCR was performed with HIF-1α specific primers.
Sandra O. Gollnick (297886) +5 more
core +1 more source
AntioxidantsAcute liver injury (ALI) is a potentially life-threatening condition lacking effective clinical drugs. Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of both inflammation and metabolism.
Jiayu Yang +11 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
EGC promotes HIF-1α proteasome pathway degradation. [PDF]
, 2013 (A) Expression curve of HIF-1α under hypoxia. The results showed that the expression level of HIF-1α reached the peak at the 6th hour, but had a slight decrease after 10 hours; (B) EGC inhibited HIF-1α expression in a dose-dependent manner in both breast
Zhiyu Wang (282312) +8 more
core +1 more source
HIF-1α contributes to Ang II-induced inflammatory cytokine production in podocytes
BMC Pharmacology and Toxicology, 2019 Background Studies have indicated that changed expression of hypoxia-inducible factor-1α (HIF-1α) in epithelial cells from the kidney could affect the renal function in chronic kidney disease (CKD).
Hao Huang +10 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions [PDF]
, 2012 Sirtuins and hypoxia-inducible transcription factors (HIF) have well-established roles in regulating cellular responses to metabolic and oxidative stress.
Candinas Daniel +43 more
core +1 more source
Additional file 1 of AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth [PDF]
, 2023 Additional file 1: Table S1. Enriched top 10 gene ontology annotations for biological process in transcriptome of S/G-deprived U87MG cells, compared to control. Table S2.
Linyong Du (7006637) +14 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Journal of the Formosan Medical Association, 2022 Background/Purpose: Recent emerging evidence indicates that dysfunction of metabolic remodeling underlies aberrant T cell immune responses in systemic lupus erythematosus (SLE).
Hsiu-Jung Liao +4 more
doaj +1 more source