Results 111 to 120 of about 136,040 (279)
Advanced Science, EarlyView.Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao +7 more
wiley +1 more source
HGF enhances HIF-1α activation.
, 2013 (A) OASFs were incubated with HGF for indicated time intervals, and HIF-1α expression was examined by Western blotting. (B) OASFs were incubated with HGF for indicated time intervals, and nucleus HIF-1α accumulation was determent by Western blotting. (C)
Ming-Chih Chou (296999) +5 more
core +1 more source
Glycine decarboxylase and HIF-1α expression are negative prognostic factors in primary resected early-stage non-small cell lung cancer. [PDF]
, 2017 Glycine decarboxylase (GLDC) was recently described as a critical enzyme of tumor-initiating cells and, thus, a driver of tumorigenesis in lung non-small cell cancer (NSCC). It is important in metabolism under hypoxic conditions. Hypoxia-inducible factor
Schmid, Ralph +7 more
core +1 more source
Advanced Science, EarlyView.This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen +7 more
wiley +1 more source
Citrullination modulation stabilizes HIF-1α to promote tumour progression
Nature CommunicationsCitrullination plays an essential role in various physiological or pathological processes, however, whether citrullination is involved in regulating tumour progression and the potential therapeutic significance have not been well explored.
Rui Chen +12 more
doaj +1 more source
PIN1 enhances the stability of HIF-1α.
, 2016 A) Lysates of cells were transfected with DNA-based siRNA expression vectors for 72 h, then exposed to hypoxia for 4 h, and then treated with CHX (10 μM) for the indicated time periods under hypoxic condition were used for Western blotting analysis with ...
Nayoung Kwon (846567) +13 more
core +1 more source
Advanced Science, EarlyView.This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka +4 more
wiley +1 more source
Crosstalk between FGF2 and HIF-1α.
, 2013 A. FGF2 and HIF-1α gene silencing using targeted-siRNA. 911 cells were transfected with FGF2 (left) or HIF-1α (right) targeted siRNA (siFGF2 or siHIF-1α, respectively).
Céline Toutain (88345) +6 more
core +1 more source
Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source
HIF-1α and HIF-2α expression in mouse kidney.
, 2012 The physiological expression pattern of HIF-1α and HIF-2α was analyzed by immunohistochemistry on kidney sections of normoxic and hypoxic (6 h, 7% O2) mice.
Ruth E. Schietke (186088) +19 more
core +1 more source