Results 111 to 120 of about 151,161 (274)
Advanced Science, EarlyView.The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang +11 more
wiley +1 more source
DMAG-induced inhibition of HIF-1α expression.
, 2013 As a complementary approach to siRNAHIF-1α treatment, DMAG-induced inhibition of HIF-1α levels in vivo (A) was examined by ELISA in the normal (uninfected) cornea and at 5 days after ocular infection. HIF-1α protein was significantly reduced at both time
Sharon A. McClellan (434587) +3 more
core +1 more source
Advanced Science, EarlyView.This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu +7 more
wiley +1 more source
1, 9 PA downregulates HIF-1α in a PHD- and HIF-1α ODD-dependent manner.
, 2013 (A) Requirement of O2 and Fe2+ in the 1, 9 PA-induced downregulation of HIF-1α. A431 cells were untreated or treated with 10 µM 1, 9 PA in 0.5% FBS culture medium under normoxic conditions in the absence or presence of DFO (100 µM) or MG132 (10 µM), and ...
Yang Lu (59885) +3 more
core +1 more source
Patologìâ, 2017 The purpose of this study was to establish the features of the expression of hif‑1α and hif-3α genes and the accumulation of HIF-1α and HIF-3α proteins in the paraventricular (PVH) and supraoptic (SO) nuclei of the hypothalamus under the conditions of ...
A. V. Abramov, V. A. Shamenko
doaj +1 more source
Advanced Science, EarlyView.USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen +7 more
wiley +1 more source
HIF-1α and HIF-2α expression in mouse kidney.
, 2012 The physiological expression pattern of HIF-1α and HIF-2α was analyzed by immunohistochemistry on kidney sections of normoxic and hypoxic (6 h, 7% O2) mice.
Ruth E. Schietke (186088) +19 more
core +1 more source
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance [PDF]
, 2015 Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM). Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely hypoxia-inducible factor-1α (HIF-1α) or HIF-2α, in human acute myeloid leukemia (AML) samples ...
Gezer, Deniz +54 more
core +1 more source
BMC Molecular and Cell BiologyBackground Sepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other papers have shown that HIF-1α has a protective effect on intestinal mucosal injury in septic rats.
Zeyong Huang +6 more
doaj +1 more source
Ecotoxicology and Environmental SafetyCr(VI) is known to be seriously toxic and carcinogenic. Hypoxia-inducible factor-1α (HIF-1α) is a crucial regulator to promote tumor development. In this study, we found that Cr(VI) significantly increased the expression of HIF-1α in A549 cells and in ...
Yanqiu Yang +7 more
doaj +1 more source