Results 131 to 140 of about 136,040 (279)

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia.

, 2018
Poor oxygenation is a common hallmark of solid cancers that strongly associates with aggressive tumor progression and treatment resistance. While a hypoxia-inducible factor 1α (HIF-1α)-associated transcriptional overexpression of the hepatocyte growth ...
Daniel M. Aebersold, Medova, Michaela, Bubendorf, Lukas, Nisa Hernández, Lluís, Lluís Nisa, Jacopo Gavini, Aebersold, Daniel, Poliakova, Michaela, Dominic Leiser, Michaela Poliaková, Aurélie Quintin, Quintin, Aurélie, Keogh-Stroka, Deborah M., Michaela Medová, Gavini, Jacopo, Astrid A. Glück, Berezowska, Sabina, Blaukat, Andree, Orlando, Eleonora, Lukas Bubendorf, Yitzhak Zimmer, Eleonora Orlando, Leiser, Dominic, Andree Blaukat, Sabina Berezowska, Glück, Astrid Andreina, Zimmer, Yitzhak, Deborah M. Stroka   +27 more
core   +1 more source

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance [PDF]

, 2015
Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM). Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely hypoxia-inducible factor-1α (HIF-1α) or HIF-2α, in human acute myeloid leukemia (AML) samples ...
Gezer, Deniz, Tessa L. Holyoake, Ratcliffe, Peter, Ratcliffe, Peter J., Iglesias, Juan Manuel, O'Duibhir, Eoghan, Panagopoulou, Theano I., Villacreces, Arnaud, Amelie V. Guitart, Ratcliffe, Peter J, Holyoake, Tessa L., Holyoake, Tessa L, Glykofrydis, Fokion, So, Chi Wai Eric, Sepulveda, Catarina, Panagopoulou, Theano I, Milica Vukovic, Dónal O'Carroll, Kranc, Kamil R, Juan Menendez-Gonzalez, Lewis Allen, Juan Manuel Iglesias, Peter J. Ratcliffe, Arnaud Villacreces, Holyoake, Tessa, Schaak, Katrin, Alasdair Ivens, Kamil R. Kranc, Vukovic, Milica, Deniz Gezer, Armesilla-Diaz, Alejandro, Guitart, Amelie V., Ivens, Alasdair, Guitart, Amelie V, Chithra Subramani, Chi Wai Eric So, Fokion Glykofrydis, Alejandro Armesilla-Diaz, Katrin Schaak, Panagopoulou, Theano, Allen, Lewis, Kranc, Kamil R., Eoghan O'Duibhir, O'Carroll, Dónal, Post, Annemarie E M, Theano I. Panagopoulou, Post, Annemarie E.M., Wood, Andrew, Catarina Sepulveda, Annemarie E.M. Post, Andrew Wood, Subramani, Chithra, Guitart, Amelie, V, Kranc, Kamil, Menendez-Gonzalez, Juan   +54 more
core   +1 more source

A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair

Advanced Science, EarlyView.
A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao, Xinyu Wang, Zhifeng Wu, Xinya Zhang, Xiao Geng, Ti Zhang, Yue Wang, Hongwei Xia, Jun Zhang, Xianbo Qiu, Cuiru Sun, Yingjie Yu, Wenli Dai, Hua Tian, Qing Cai   +14 more
wiley   +1 more source

Suppression of hepcidin transcript levels is not mediated by HIF-1α or HIF-2α.

, 2013
(A) SiRNA-mediated knock-down of HIF-1α (1α) or HIF-2α (2α) did not attenuate the down-regulation of hepcidin mRNA levels in HepG2 cells after 16 h of stimulation; luciferase (luc) siRNA served as negative control.
Bernd Klanke (186110), Christina Warnecke (369153), Anja-Katrin Bosserhoff (312341), Ulrike Maegdefrau (369152), Gunnar Schley (186149), Melanie Volke (369151), Daniel P. Gale (288230), Kai-Uwe Eckardt (186164), Patrick H. Maxwell (22308)   +8 more
core   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

HIF-1α is involved in the regulation of MUC5AC expression.

, 2014
When HIF-1α expression is increased, MUC5AC expression is induced; conversely, when HIF-1α expression is decreased, MUC5AC expression is reduced accordingly. (A) Gain-of-function study with mammalian HIF-1α expression vector in NCI-H292 cells. DNA of the
Joo-Heon Yoon (311505), Chang-Hoon Kim (491637), Woo-Chul Shin (565860), Yoon-Ju Kim (565859), Hyung-Ju Cho (207601), Hyun-Ah Song (565861)   +5 more
core   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

HIF-1α in Heart: Protective Mechanisms

, 2013
Hypoxia-inducible factor- 1α (HIF-1α) is a transcription factor that directs many of the cellular responses to hypoxia. In these studies, we have used a mouse model containing a cardiac-specific, oxygen-stabilized, doxycycline (Dox)-off regulated HIF-1α ...
Chen, Ping, Li, Ying, Shohet, Ralph, Der, Tatyana, Ardell, Chris, Wright, Gary L., Wu, Joe, Chen, Minghua   +7 more
core   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source