Results 131 to 140 of about 136,719 (278)
Advanced Science, EarlyView.A sprayable near‐infrared‐activated nanoplatform incorporating MXene, ZnHCF nanozyme, and deferoxamine efficiently breaks the vicious cycle of diabetic wounds. Upon irradiation, interfacial electron transfer and photothermal effects enhance multi‐enzyme activity, enabling explosive ROS elimination, alleviation of hypoxia, and controlled DFO release ...
Jiahao Guo +5 more
wiley +1 more source
Correlation of HIF-1β with HIF-1α and VEGF. [PDF]
, 2015 HIF, Hypoxia Inducible Factor; VEGF, Vascular Endothelial Growth FactorCorrelation of HIF-1β with HIF-1α and VEGF.
Najla Fakhruddin (750404) +5 more
core +1 more source
Advanced Science, EarlyView.A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley +1 more source
ELR510444 decreases HIF-1α and HIF-2α expression. [PDF]
, 2013 (A) ELR510444 (chemical structure on left) inhibits HIF-1α activity. RCC4 cells were treated with the indicated concentrations of ELR510444 for 16 h. Cells were harvested, nuclei isolated and lysed, and HIF-1α activity was measured using a commercial ...
Joe D. Lewis (334193) +8 more
core +1 more source
Neurobiology of Disease, 2014 Recent findings suggest that Notch-1 signaling contributes to neuronal death in ischemic stroke, but the underlying mechanisms are unknown. Hypoxia inducible factor-1α (HIF-1α), a global regulator of cellular responses to hypoxia, can interact with Notch
Yi-Lin Cheng +13 more
doaj +1 more source
FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model
Advanced Science, EarlyView.FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble +9 more
wiley +1 more source
Expression and correlation of HIF-1α, HIF-2α and HAF in ccRCC. [PDF]
, 2018 (A, C and E) Positive nuclear staining to HIF-1α, HIF-2α and HAF, respectively, in primary ccRCCs at high magnification (x100). (B, D and F) Heterogenous nuclear staining of HIF-1α, HIF-2α and HAF, respectively, in a tumor at low magnification (x20). (G,
Nathalie Rioux-Leclercq (249571) +10 more
core +1 more source
Advanced Science, EarlyView.This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng +14 more
wiley +1 more source
Immunohistological and western blot analyses of HIF-1α. [PDF]
, 2016 (A) PAB liver stained by HIF-1α (original magnification, ×20). (B) Sham-operated control liver stained by HIF-1α (original magnification, ×20). (C) Enlarged view of the boxed area in the Image (A) (original magnification, ×100). (D) Western blot analysis
Sadataka Kawachi (849638) +12 more
core +1 more source
Ecotoxicology and Environmental SafetyCr(VI) is known to be seriously toxic and carcinogenic. Hypoxia-inducible factor-1α (HIF-1α) is a crucial regulator to promote tumor development. In this study, we found that Cr(VI) significantly increased the expression of HIF-1α in A549 cells and in ...
Yanqiu Yang +7 more
doaj +1 more source