Results 151 to 160 of about 136,040 (279)
陆军军医大学学报Objective To investigate the mechanism by which hypoxia-inducible factor (HIF)-1α and circ-UBE2G1 mutually regulate and promote thyroid cancer (THCA) metastasis under hypoxic microenvironment.
DENG Xiaoling +2 more
doaj +1 more source
Protein replacement of endogenous HIF-1α protein using 47snoMEN.
, 2016 (a) Structures for the targeted endogenous HIF-1α protein replacement plasmid using U47snoMEN. (b) Schematic diagram of endogenous HIF complex. (c) U2OS and U2OS GFP–HIF-1α stable cell lines were exposed to hypoxia prior to lysis and analysed by Western ...
Motoharu Ono (259551) +10 more
core +1 more source
FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model
Advanced Science, EarlyView.FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble +9 more
wiley +1 more source
Correlation of HIF-1β with HIF-1α and VEGF.
, 2015 HIF, Hypoxia Inducible Factor; VEGF, Vascular Endothelial Growth FactorCorrelation of HIF-1β with HIF-1α and VEGF.
Najla Fakhruddin (750404) +5 more
core +1 more source
Advanced Science, EarlyView.This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng +14 more
wiley +1 more source
ELR510444 decreases HIF-1α and HIF-2α expression.
, 2013 (A) ELR510444 (chemical structure on left) inhibits HIF-1α activity. RCC4 cells were treated with the indicated concentrations of ELR510444 for 16 h. Cells were harvested, nuclei isolated and lysed, and HIF-1α activity was measured using a commercial ...
Joe D. Lewis (334193) +8 more
core +1 more source
Advanced Science, EarlyView.This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun +14 more
wiley +1 more source
Expression and correlation of HIF-1α, HIF-2α and HAF in ccRCC.
, 2018 (A, C and E) Positive nuclear staining to HIF-1α, HIF-2α and HAF, respectively, in primary ccRCCs at high magnification (x100). (B, D and F) Heterogenous nuclear staining of HIF-1α, HIF-2α and HAF, respectively, in a tumor at low magnification (x20). (G,
Nathalie Rioux-Leclercq (249571) +10 more
core +1 more source
Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy
Advanced Science, EarlyView.A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao +11 more
wiley +1 more source
Hypoxia and the endometrium: An indispensable role for HIF-1α as therapeutic strategies
Redox BiologyHypoxia-inducible factor 1 alpha (HIF-1α) is a major molecular mediator of the hypoxic response. In the endometrium, local hypoxic conditions induced by hormonal fluctuations and endometrial vascular remodeling contribute to the production of HIF-1α ...
Wanlin Dai +8 more
doaj +1 more source