Results 141 to 150 of about 84,588 (227)

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

Dual Targeting of HIF-1α and DLL4 by Isoxanthohumol Potentiates Immune Checkpoint Blockade. [PDF]

Int J Mol Sci
Kim D, You J, Bae SH, Jeong JH, Jung JH, Kim JA, Lee YM.   +6 more
europepmc   +1 more source

CCL26‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik, Sevil Tekman, Betul Gundogdu, Ahsen Kilic, Rumeysa Polat, Omer Aydin, Omer Faruk Karatas   +6 more
wiley   +1 more source

The HIF-1α Pathway Regulates Satellite Cell Fate During Aging Through Histone Lactylation. [PDF]

Aging Cell
Piccoli M, Mornatti L, Lavota I, Risuglia M, Creo P, Vizzino E, Rota P, Tarantino A, Mangiavini L, Ciconte G, Signorelli P, Peretti GM, Cenci S, Pappone C, Anastasia L, Cirillo F.   +15 more
europepmc   +1 more source

Hypoxia Induces a Mitotic Survival Advantage After Radiotherapy in Head and Neck Cancer Cells

International Journal of Cancer, EarlyView.
Hypoxic tumor environments significantly limit radiotherapy effectiveness against cancer, particularly in head and neck squamous cell carcinoma (HNSCC). Here, the authors tracked hypoxic and post‐hypoxic cells using a hypoxia‐fate mapping system in human papillomavirus (HPV)‐positive and HPV‐negative HNSCC models.
Marilyn Wegge, Rüveyda Dok, Ludwig J. Dubois, Sandra Nuyts   +3 more
wiley   +1 more source

HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm. [PDF]

Bone Res
Weng Y, Xiong J, Zhao Q, Tan Z.
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Quercetin ameliorates cyclophosphamide-induced premature ovarian insufficiency by modulating SIRT1/HIF-1α pathway. [PDF]

J Ovarian Res
Wang M, Chen H, Lin S, Meng Z, Zhang Y, Liu F, Li M, Sun C, Guan M, Song L, Zhao G, Zhang D, Qin J.   +12 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Prognostic Value of UBE2S, HIF-1α, and FOXM1 Expression in Esophageal Squamous Cell Carcinoma. [PDF]

Anal Cell Pathol (Amst)
Li W, Zhou K, Li M, Su L, Liu X, Lv Y, Ma Y.   +6 more
europepmc   +1 more source