Results 141 to 150 of about 136,719 (278)

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

DKG stabilizes HIF-1α by inhibiting HIF-1α proline hydroxylation and degradation. [PDF]

, 2014
(A) DKG increases HIF-1α protein stability. MDA-MB-231 cells were pretreated with DKG (5 mM, 2-hour), then treated with CHX (20 µg/ml) in the presence or absence of DKG (5 mM) for an additional time period as indicated (upper panel).
Peifeng Hou (665040), Chun-Ting Cheng (665042), Ching-Ying Kuo (665041), David K. Ann (665043), Jing-Ping Liou (141917), Qiang Chen (114038)   +5 more
core   +1 more source

Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms

Brazilian Journal of Medical and Biological Research, 2017
The aim of this study was to investigate the mechanism of propranolol on the regression of hemangiomas. Propranolol-treated hemangioma tissues were collected and the expression of hypoxia inducible factor-1α (HIF-1α) was examined. We also established HIF-
Y.Z. Chen, N. Bai, J.H. Bi, X.W. Liu, G.Q. Xu, L.F. Zhang, X.Q. Li, R. Huo   +7 more
doaj   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance [PDF]

, 2015
Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM). Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely hypoxia-inducible factor-1α (HIF-1α) or HIF-2α, in human acute myeloid leukemia (AML) samples ...
Gezer, Deniz, Tessa L. Holyoake, Ratcliffe, Peter, Ratcliffe, Peter J., Iglesias, Juan Manuel, O'Duibhir, Eoghan, Panagopoulou, Theano I., Villacreces, Arnaud, Amelie V. Guitart, Ratcliffe, Peter J, Holyoake, Tessa L., Holyoake, Tessa L, Glykofrydis, Fokion, So, Chi Wai Eric, Sepulveda, Catarina, Panagopoulou, Theano I, Milica Vukovic, Dónal O'Carroll, Kranc, Kamil R, Juan Menendez-Gonzalez, Lewis Allen, Juan Manuel Iglesias, Peter J. Ratcliffe, Arnaud Villacreces, Holyoake, Tessa, Schaak, Katrin, Alasdair Ivens, Kamil R. Kranc, Vukovic, Milica, Deniz Gezer, Armesilla-Diaz, Alejandro, Guitart, Amelie V., Ivens, Alasdair, Guitart, Amelie V, Chithra Subramani, Chi Wai Eric So, Fokion Glykofrydis, Alejandro Armesilla-Diaz, Katrin Schaak, Panagopoulou, Theano, Allen, Lewis, Kranc, Kamil R., Eoghan O'Duibhir, O'Carroll, Dónal, Post, Annemarie E M, Theano I. Panagopoulou, Post, Annemarie E.M., Wood, Andrew, Catarina Sepulveda, Annemarie E.M. Post, Andrew Wood, Subramani, Chithra, Guitart, Amelie, V, Kranc, Kamil, Menendez-Gonzalez, Juan   +54 more
core   +1 more source

mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage

BMC Molecular and Cell Biology
Background Sepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other papers have shown that HIF-1α has a protective effect on intestinal mucosal injury in septic rats.
Zeyong Huang, Wenbin Teng, Liuxu Yao, Kai Xie, Suqin Hang, Rui He, Yuhong Li   +6 more
doaj   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

A Pathology‐Instructed Theranostic Platform with Mechanoadaptive and ROS‐Powered Nanobreathing Functions for Precision Myocardial Repair

Advanced Science, EarlyView.
We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...
Zheng Luo, Cui Yang, Liuzhou Mao, Panqin Ma, Chiyu Jia, Karen Yuanting Tang, Xian Jun Loh, Yun‐Long Wu   +7 more
wiley   +1 more source