Results 121 to 130 of about 136,040 (279)

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Bamboo‐Like Whiskers‐Reinforced Bioceramics Accelerate Large Segmental Bone Regeneration via Dual Modulation of Type‐H Vessels and Osteoinduction

Advanced Science, EarlyView.
The graphical abstract image of bamboo‐like whisker‐reinforced Ca‐P bioceramics accelerating large segmental bone regeneration. ABSTRACT Regenerative repair of segmental bone defect remains a major clinical challenge. The conventional mental implants suffer from mechanical strength mismatch and long‐term foreign bodies presence.
Cong Feng, Haibo Teng, Chuyao Xu, Jiaze He, Keting Liu, Xueying Li, Kai Zhang, Xiangdong Zhu, Xiangfeng Li, Jianguo Xu, Xingdong Zhang   +10 more
wiley   +1 more source

DMAG-induced inhibition of HIF-1α expression.

, 2013
As a complementary approach to siRNAHIF-1α treatment, DMAG-induced inhibition of HIF-1α levels in vivo (A) was examined by ELISA in the normal (uninfected) cornea and at 5 days after ocular infection. HIF-1α protein was significantly reduced at both time
Sharon A. McClellan (434587), Linda D. Hazlett (434588), Elizabeth A. Berger (434586), Kerry S. Vistisen (164917)   +3 more
core   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

1, 9 PA downregulates HIF-1α in a PHD- and HIF-1α ODD-dependent manner.

, 2013
(A) Requirement of O2 and Fe2+ in the 1, 9 PA-induced downregulation of HIF-1α. A431 cells were untreated or treated with 10 µM 1, 9 PA in 0.5% FBS culture medium under normoxic conditions in the absence or presence of DFO (100 µM) or MG132 (10 µM), and ...
Yang Lu (59885), Zhen Fan (59888), Haiquan Lu (358224), Xinqun Li (59884)   +3 more
core   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage

BMC Molecular and Cell Biology
Background Sepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other papers have shown that HIF-1α has a protective effect on intestinal mucosal injury in septic rats.
Zeyong Huang, Wenbin Teng, Liuxu Yao, Kai Xie, Suqin Hang, Rui He, Yuhong Li   +6 more
doaj   +1 more source

p53-dependent HIF-1α /autophagy mediated glycolysis to support Cr(VI)-induced cell growth and cell migration

Ecotoxicology and Environmental Safety
Cr(VI) is known to be seriously toxic and carcinogenic. Hypoxia-inducible factor-1α (HIF-1α) is a crucial regulator to promote tumor development. In this study, we found that Cr(VI) significantly increased the expression of HIF-1α in A549 cells and in ...
Yanqiu Yang, Bin Song, Minna Guo, Jianfeng Gao, Liping Jiang, Qiujuan Li, Yong Liu, Jun Cao   +7 more
doaj   +1 more source

Expression of Hypoxia Inducible Factor-1α (HIF-1α) via Photodynamic Therapy in Oral Squamous Cell Carcinoma

, 2010
口腔癌的排名有逐年上升的趨勢，年增率高居癌症第一位，死亡率過半。癌症治療的方式多樣化，目地在延長病患壽命，甚至進一步治癒癌症。以手術切除常因造成顏面傷殘及病患心理壓力而放棄，為尋求減少侵犯性治療，進行新興的光動力治療。光動力治療(Photodynamic therapy, PDT)是新興的癌症治療的方式，光動力治療已運用在其它不易手術部位的癌療。光動力治療的藥物也有進一步的改善，先前我們採用新研發的二代光感藥物(photosensitizer) 5-氨基酮戊酸(5-aminolevulinic acid,
曾建福, Tseng, Chien-Fu
core  

HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation

, 2001
Hypoxia-inducible factor-1α (HIF-1α) plays a central role in oxygen homeostasis. In normoxia, HIF-1α is a short lived protein, whereas hypoxia rapidly increases HIF-1α protein levels by relaxing its ubiquitin–proteasome-dependent degradation.
Emmanuel Gothié, Pouysségur, Jacques, Edurne Berra, Jacques Pouysségur, Richard, Darren E, Berra, Edurne, Darren E Richard, Gothié, Emmanuel   +7 more
core   +1 more source