Results 11 to 20 of about 151,161 (274)

Compensatory Mitophagy via NEDD4/HIF-1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα. [PDF]

Adv Sci (Weinh)
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Feng D, Shen Q, Zhang J, Liu J, Gui Z, Wang Z, Han Q, Fei S, Chen H, Sun L, Tao J, Han Z, Ju X, Gu M, Zhang J, Tan R.   +15 more
europepmc   +2 more sources

Hydrostatic pressure activates HIF-1α via β-catenin to promote stemness in breast cancer cells. [PDF]

FEBS Open Bio
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Zhai D, Xu Y, Ma J, Duangrat R, Yan C, Liang J, Wei H, Jiang B, Li TS.   +8 more
europepmc   +2 more sources

Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities [PDF]

, 2014
E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
Dias, David M, Carles Galdeano (1305135), Galdeano, Carles, Dias, David M., David M. Dias (1340694), Van Molle, Inge, Gadd, Morgan Stuart, Ciulli, Alessio, Sarah Hewitt (1340700), Soares, Pedro, Galdeano , Carles, Pedro Soares (393566), Gadd, Morgan S., Salvatore Scaffidi (1340703), Inge Van Molle (1284120), Morgan S. Gadd (149371), Scaffidi, Salvatore, Ipek Birced (1340697), Alessio Ciulli (762789), Hewitt, Sarah, Birced, Ipek   +20 more
core   +1 more source

Hypoxia regulates adipose mesenchymal stem cells proliferation, migration, and nucleus pulposus-like differentiation by regulating endoplasmic reticulum stress via the HIF-1α pathway

Journal of Orthopaedic Surgery and Research, 2023
Objective Hypoxia can promote stem cell proliferation and migration through HIF-1α. Hypoxia can regulate cellular endoplasmic reticulum (ER) stress. Some studies have reported the relationship among hypoxia, HIF-α, and ER stress, however, while little is
Jianxin Wu, Lei Yu, Yi Liu, Bing Xiao, Xiaojian Ye, Hong Zhao, Yanhai Xi, Zhicai Shi, Weiheng Wang   +8 more
doaj   +1 more source

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]

, 2014
The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm, Moniz, Sonia, David Komander, Bremm, Anja, Komander, David, Sonia Rocha, Mader, Julia, Rocha, Sonia, Sonia Moniz, Julia Mader   +9 more
core   +1 more source

Studying the C1772T polymorphism of Hif-1α and TGF-β3 IVS5+104 A/G polymorphism in children with congenital non-syndromic neural tube defects and their mothers

Cellular and Molecular Biology, 2018
Prevalence of neural tube defect (NTD) has reduced after folic acid intake. However; which mechanisms are effective in NTD are not known exactly. In this study; due to the possible effects on hypoxic pathway and embryonic development, particularly on extracellular matrix components, Hif-1α Pro582Ser and TGF-β3 IVS5+104 A/G SfaN1 polymorphisms were ...
ć°brahim Halil Yildirim, Nadir Koçak
openaire   +2 more sources

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +1 more source

HIF-1α/MMP-9 Axis Is Required in the Early Phases of Skeletal Myoblast Differentiation under Normoxia Condition In Vitro

Cells, 2023
Hypoxia-inducible factor (HIF)-1α represents an oxygen-sensitive subunit of HIF transcriptional factor, which is usually degraded in normoxia and stabilized in hypoxia to regulate several target gene expressions.
Flaminia Chellini, Alessia Tani, Martina Parigi, Francesco Palmieri, Rachele Garella, Sandra Zecchi-Orlandini, Roberta Squecco, Chiara Sassoli   +7 more
doaj   +1 more source

Effects of siRNA-mediated HIF-1α gene silencing on angiogenesis in osteosarcoma

Pakistan Journal of Medical Sciences, 2017
Objective: To explore angiogenesis in osteosarcoma under the condition of hypoxia-inducible factor (HIF)-1? gene silenced by small interference RNA (siRNA).Methods: The SaOS-2 osteosarcoma cells, transfected with the recombinant plasmid pSilencer2.1-HIF-1? or pSilencer2.1-SCR, were classified as HIF-1?/siRNA group or SCR/siRNA group, respectively.
Zhang, Xu-dong, Wu, Qiang, Yang, Shu-hua
openaire   +2 more sources

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis. [PDF]

, 2011
BACKGROUND: Clear cell renal cell carcinoma (CCRCC) is the commonest form of kidney cancer. Up to 91% have biallelic inactivation of VHL, resulting in stabilisation of HIF-α subunits.
T Bhattacharyya, M A Esteban, S Kiriakidis, Kiriakidis, Serafim, Kiriakidis, S, P H Maxwell, Barod, R, M N Khan, Connor, T, Andrikopoulos, P, Bhattacharyya, T, Ashcroft, M, R Barod, T Connor, M Ashcroft, Khan, MN, Maxwell, PH, Esteban, MA, P Andrikopoulos   +18 more
core   +2 more sources