Results 11 to 20 of about 84,588 (227)

Insulin regulates hypoxia-inducible factor-1α transcription by reactive oxygen species sensitive activation of Sp1 in 3T3-L1 preadipocyte. [PDF]

PLoS ONE, 2013
Oxygen sensing transcription factor HIF-1 is activated due to accumulation of regulatory subunit HIF-1α by posttranslational stability mechanism during hypoxia or by several other stimuli even in normoxia.
Sudipta Biswas, Reshmi Mukherjee, Nisha Tapryal, Amit K Singh, Chinmay K Mukhopadhyay   +4 more
doaj   +1 more source

Hypoxia regulates adipose mesenchymal stem cells proliferation, migration, and nucleus pulposus-like differentiation by regulating endoplasmic reticulum stress via the HIF-1α pathway

Journal of Orthopaedic Surgery and Research, 2023
Objective Hypoxia can promote stem cell proliferation and migration through HIF-1α. Hypoxia can regulate cellular endoplasmic reticulum (ER) stress. Some studies have reported the relationship among hypoxia, HIF-α, and ER stress, however, while little is
Jianxin Wu, Lei Yu, Yi Liu, Bing Xiao, Xiaojian Ye, Hong Zhao, Yanhai Xi, Zhicai Shi, Weiheng Wang   +8 more
doaj   +1 more source

HIF-1α Induces Multidrug Resistance in Gastric Cancer Cells by Inducing MiR-27a. [PDF]

PLoS ONE, 2015
This study aimed to determine the correlation between HIF-1α and miR-27a expression and to evaluate the effect of inhibition of HIF-1α expression on miR-27a expression and drug resistance in gastric cancer (GC).
Qun Zhao, Yong Li, Bi-Bo Tan, Li-Qiao Fan, Pei-Gang Yang, Yuan Tian   +5 more
doaj   +1 more source

HIF-1α/MMP-9 Axis Is Required in the Early Phases of Skeletal Myoblast Differentiation under Normoxia Condition In Vitro

Cells, 2023
Hypoxia-inducible factor (HIF)-1α represents an oxygen-sensitive subunit of HIF transcriptional factor, which is usually degraded in normoxia and stabilized in hypoxia to regulate several target gene expressions.
Flaminia Chellini, Alessia Tani, Martina Parigi, Francesco Palmieri, Rachele Garella, Sandra Zecchi-Orlandini, Roberta Squecco, Chiara Sassoli   +7 more
doaj   +1 more source

Studying the C1772T polymorphism of Hif-1α and TGF-β3 IVS5+104 A/G polymorphism in children with congenital non-syndromic neural tube defects and their mothers

Cellular and Molecular Biology, 2018
Prevalence of neural tube defect (NTD) has reduced after folic acid intake. However; which mechanisms are effective in NTD are not known exactly. In this study; due to the possible effects on hypoxic pathway and embryonic development, particularly on extracellular matrix components, Hif-1α Pro582Ser and TGF-β3 IVS5+104 A/G SfaN1 polymorphisms were ...
ć°brahim Halil Yildirim, Nadir Koçak
openaire   +2 more sources

Ginsenoside compound K inhibits growth of lung cancer cells via HIF-1α-mediated glucose metabolism

Cellular and Molecular Biology, 2019
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths. Compound K, an active metabolite of ginsenosides, is reported to exhibit anti-cancer property in various types of human malignancies. The present study investigated the role of compound K on glucose metabolism in NSCLC cells and its underlying mechanism.
Hua-Fei, Chen, Li-Xin, Wu, Xiao-Feng, Li, You-Cai, Zhu, Wen-Xian, Wang, Chun-Wei, Xu, Zhang-Zhou, Huang, Kai-Qi, Du   +7 more
openaire   +3 more sources

Prognostic stratification based on HIF-1α signaling for evaluating hypoxia status and immune landscape in hepatocellular carcinoma

Journal of Big Data, 2023
Hepatocellular carcinoma (HCC) has a desmoplastic and hypoxic tumor microenvironment (TME), resulting in poor prognosis and treatment resistance. This study aimed to construct a novel prognostic classifier to investigate the degree of hypoxia and immune ...
Hongkai Zhuang, Zedan Zhang, Bo Chen, Chenwei Tang, Xinming Chen, Wenliang Tan, Lei Yang, Zhiqin Xie, Xiaowu Ma, Qingbin Wang, Bingkun Wang, Changzhen Shang, Yajin Chen   +12 more
doaj   +1 more source

hZIP1 Inhibits Progression of Clear Cell Renal Cell Carcinoma by Suppressing NF-kB/HIF-1α Pathway

Frontiers in Oncology, 2021
PurposeAccumulating literature has suggested that hZIP1 and HIF-1α play vital roles in the tumor process of clear cell renal cell carcinoma (ccRCC). However, the functional roles of hZIP1 and HIF-1α in ccRCC remain largely unknown.MethodsHIF-1α protein ...
Bo Zhan, Xiao Dong, Yulin Yuan, Zheng Gong, Bohan Li   +4 more
doaj   +1 more source

Correlation of VEGF and HIF-1α in breast carcinoma (an immunohistochemical study)

IP Journal of Diagnostic Pathology and Oncology, 2020
Introduction: By 2030 the incidence of breast cancer in India will increase to around 200,000 per year. During tumor growth, angiogenesis is induced by many stimuli. Reduced oxygen stimulates hypoxia induced factor 1 alpha (HIF-1?), activating proangiogenic cytokines i.e. vascular endothelial growth factor (VEGF).
openaire   +2 more sources

Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival after Islet Transplantation of Human and Mouse Islets

Cell Transplantation, 2013
A high proportion of β-cells die within days of islet transplantation. Reports suggest that induction of hypoxia-inducible factor-1α (HIF-1α) predicts adverse transplant outcomes.
Rebecca A. Stokes, Kim Cheng, Natasha Deters, Sue Mei Lau, Wayne J. Hawthorne, Philip J. O'connell, Jessica Stolp, Shane Grey, Thomas Loudovaris, Thomas W. Kay, Helen E. Thomas, Frank J. Gonzalez, Jenny E. Gunton   +12 more
doaj   +1 more source