Results 21 to 30 of about 84,588 (227)

Emerging Roles Of hsa-circ-0046600 Targeting The miR-640/HIF-1α Signalling Pathway In The Progression Of HCC.

OncoTargets and therapy, 2019
Circular RNAs (circRNAs) play important roles in the development and progression of various human cancers. hsa-circ-0046600 is a circRNA of unknown function. The purpose of this study was to investigate the biological function of hsa-circ-0046600 in hepatocellular carcinoma (HCC) and elucidate the possible molecular mechanisms of this circRNA.GSE97332,
Zhai,Zhensheng, Fu,Qiang, Liu,Chuanjiang, Zhang,Xu, Jia,Pengchong, Xia,Peng, Liu,Pan, Liao,Shixiu, Qin,Tao, Zhang,Hongwei   +9 more
openaire   +3 more sources

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.

PLoS ONE, 2010
BackgroundHypoxia inducible factor-1α (HIF-1α) is responsible for the majority of HIF-1-induced gene expression changes under hypoxia and for the "angiogenic switch" during tumor progression.
Lavinia Nardinocchi, Valentina Pantisano, Rosa Puca, Manuela Porru, Aurora Aiello, Annalisa Grasselli, Carlo Leonetti, Michal Safran, Gideon Rechavi, David Givol, Antonella Farsetti, Gabriella D'Orazi   +11 more
doaj   +1 more source

Hypoxia inducible factor-1α is an important regulator of macrophage biology

Heliyon, 2023
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate
Bingquan Qiu, Piaoliu Yuan, Xiaojuan Du, Hongfang Jin, Junbao Du, Yaqian Huang   +5 more
doaj   +1 more source

Overexpression of Hypoxia-Inducible Factor-1α and Its Relation with Aggressiveness and Grade of Oral Squamous Cell Carcinoma

Diagnostics, 2023
Hypoxia-inducible factor-1α (HIF-1α) has been shown to be involved in cancer metastasis in several cancer types. There is however conflicting evidence of HIF-1α expression with oral cancer prognosis.
Sumera Sumera, Asif Ali, Yasar M. Yousafzai, Zubair Durrani, Mohammed Alorini, Benish Aleem, Rabia Zahir   +6 more
doaj   +1 more source

Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

Hepatology, 2016
Cancer metastasis is a multistep process that involves a series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors. This study investigated the role of tissue inhibitor of metalloproteinases (TIMP) 2 in the context of ...
Chan, Lo Kong, Lo, Regina Cheuk Lam, Lee, Joyce Man Fong, Wong, Carmen Chak Lui, Wong, Jack Chun Ming, Ng, Irene Oi Lin, Kai, Alan Ka Lun   +6 more
openaire   +5 more sources

HIF-1α protects against oxidative stress by directly targeting mitochondria

Redox Biology, 2019
The transcription factor hypoxia inducible factor-1α (HIF-1α) mediates adaptive responses to oxidative stress by nuclear translocation and regulation of gene expression.
Hong-Sheng Li, Yan-Ni Zhou, Lu Li, Sheng-Fu Li, Dan Long, Xue-Lu Chen, Jia-Bi Zhang, Li Feng, You-Ping Li   +8 more
doaj   +1 more source

HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis

World Journal of Surgical Oncology, 2020
Background The role of hypoxia-inducible factor-1α (HIF-1α) in primary colorectal cancer (CRC) and colorectal liver metastasis (CRLM) has remained unclear.
Yuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saito, Chie Takasu, Shinichiro Yamada, Mitsuo Shimada   +7 more
doaj   +1 more source

Silencing HIF-1α reduces the adhesion and secretion functions of acute leukemia hBMSCs

Brazilian Journal of Medical and Biological Research, 2012
Hypoxia inducible factor-1α (HIF-1α) is an important transcription factor, which plays a critical role in the formation of solid tumor and its microenviroment.
Zeng Dong-Feng, Liu Ting, Chang Cheng, Zhang Xi, Liang Xue, Chen Xing-Hua, Kong Pei-Yan   +6 more
doaj   +1 more source

Reciprocal Regulation of MAGED2 and HIF-1α Augments Their Expression under Hypoxia: Role of cAMP and PKA Type II

Cells, 2022
Hypoxia stabilizes the transcription factor HIF-1α, which promotes the transcription of many genes essential to adapt to reduced oxygen levels. Besides proline hydroxylation, expression of HIF-1α is also regulated by a range of other posttranslational ...
Elie Seaayfan, Sadiq Nasrah, Lea Quell, Aline Radi, Maja Kleim, Ralph T. Schermuly, Stefanie Weber, Kamel Laghmani, Martin Kömhoff   +8 more
doaj   +1 more source

Hypoxia-inducible factor-1alpha and MAPK co-regulate activation of hepatic stellate cells upon hypoxia stimulation. [PDF]

PLoS ONE, 2013
BACKGROUND: Hepatic stellate cell (HSC) plays a key role in pathogenesis of liver fibrosis. During liver injury, hypoxia in local micro-environment is inevitable.
Yueqin Wang, Yimin Huang, Fei Guan, Yan Xiao, Jing Deng, Huoying Chen, Xiaolin Chen, Jianrong Li, Hanju Huang, Chunwei Shi   +9 more
doaj   +1 more source