Results 21 to 30 of about 136,040 (279)
Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities [PDF]
, 2014 E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
Dias, David M +20 more
core +1 more source
Journal of Orthopaedic Surgery and Research, 2023 Objective Hypoxia can promote stem cell proliferation and migration through HIF-1α. Hypoxia can regulate cellular endoplasmic reticulum (ER) stress. Some studies have reported the relationship among hypoxia, HIF-α, and ER stress, however, while little is
Jianxin Wu +8 more
doaj +1 more source
Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]
, 2014 The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm +9 more
core +1 more source
Cellular and Molecular Biology, 2018 Prevalence of neural tube defect (NTD) has reduced after folic acid intake. However; which mechanisms are effective in NTD are not known exactly. In this study; due to the possible effects on hypoxic pathway and embryonic development, particularly on extracellular matrix components, Hif-1α Pro582Ser and TGF-β3 IVS5+104 A/G SfaN1 polymorphisms were ...
ć°brahim Halil Yildirim, Nadir Koçak
openaire +2 more sources
HIF-1α, a novel piece in the NF-κB puzzle [PDF]
, 2015 Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core +1 more source
Cells, 2023 Hypoxia-inducible factor (HIF)-1α represents an oxygen-sensitive subunit of HIF transcriptional factor, which is usually degraded in normoxia and stabilized in hypoxia to regulate several target gene expressions.
Flaminia Chellini +7 more
doaj +1 more source
Ginsenoside compound K inhibits growth of lung cancer cells via HIF-1α-mediated glucose metabolism
Cellular and Molecular Biology, 2019 Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths. Compound K, an active metabolite of ginsenosides, is reported to exhibit anti-cancer property in various types of human malignancies. The present study investigated the role of compound K on glucose metabolism in NSCLC cells and its underlying mechanism.
Hua-Fei, Chen +7 more
openaire +3 more sources
HIF-1α Induces Multidrug Resistance in Gastric Cancer Cells by Inducing MiR-27a. [PDF]
PLoS ONE, 2015 This study aimed to determine the correlation between HIF-1α and miR-27a expression and to evaluate the effect of inhibition of HIF-1α expression on miR-27a expression and drug resistance in gastric cancer (GC).
Qun Zhao +5 more
doaj +1 more source
Correlation of VEGF and HIF-1α in breast carcinoma (an immunohistochemical study)
IP Journal of Diagnostic Pathology and Oncology, 2020 Introduction: By 2030 the incidence of breast cancer in India will increase to around 200,000 per year. During tumor growth, angiogenesis is induced by many stimuli. Reduced oxygen stimulates hypoxia induced factor 1 alpha (HIF-1?), activating proangiogenic cytokines i.e. vascular endothelial growth factor (VEGF).
openaire +2 more sources
Cell Transplantation, 2013 A high proportion of β-cells die within days of islet transplantation. Reports suggest that induction of hypoxia-inducible factor-1α (HIF-1α) predicts adverse transplant outcomes.
Rebecca A. Stokes +12 more
doaj +1 more source