Parkin-independent mitophagy controls chemotherapeutic response in cancer cells [PDF]
, 2017 Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer.
Bossowski, Jozef P. +13 more
core +2 more sources
The effect of 4 weeks of continuous aerobic training with different volumes and starvation on the expression of some genes involved in liver mitophagy in healthy male Wistar rats [PDF]
ورزش و علوم زیست حرکتیIntroduction and Purpose: An increase in the number of defective mitochondria and their persistence can lead to apoptosis and necrosis of cells. Regular physical exercise along with time-restricted eating (TRE) can play an important role in improving ...
Hamzeh Bayani +3 more
doaj +1 more source
BNIP3 contributes to cisplatin‐induced apoptosis in ovarian cancer cells
FEBS Open Bio, 2020 BNIP3 is a proapoptotic protein that mediates apoptosis, necrosis and autophagy. However, the involvement of BNIP3 in cisplatin‐induced apoptosis in ovarian cancer is not clear.
Jinghui Jia +6 more
doaj +1 more source
A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia
Autophagy Reports, 2023 BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He +4 more
doaj +1 more source
Cerebral Ischemic Preconditioning Aggravates Death of Oligodendrocytes
Biomolecules, 2022 Neurodegeneration can benefit from ischemic preconditioning, a natural adaptive reaction to sublethal noxious stimuli. Although there is growing interest in advancing preconditioning to preserve brain function, preconditioning is not yet considered ...
Teng Guan +7 more
doaj +1 more source
Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology.
PLoS ONE, 2015 Bnip3 is a hypoxia-regulated member of the Bcl-2 family of proteins that is implicated in apoptosis, programmed necrosis, autophagy and mitophagy. Mitochondria are thought to be the primary targets of Bnip3 although its activities may extend to the ER ...
John W Thompson +7 more
doaj +1 more source
Expression and Functional Characterization of the BNIP3 Protein in Renal Cell Carcinomas
Translational Oncology, 2017 BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1.
Stephan Macher-Goeppinger +6 more
doaj +1 more source
Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. [PDF]
, 2020 Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced ...
Chen, Wei-Rong +8 more
core
Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. [PDF]
, 2016 Mitochondria abnormalities in skeletal muscle may contribute to frailty and sarcopenia, commonly present in patients with chronic kidney disease (CKD).
Billings, Frederic T +9 more
core +1 more source
Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice [PDF]
, 2014 Purpose: Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment. Tumor growth increases oxidative stress and cytokine production, which causes skeletal muscle wasting and cardiac dysfunction. The purpose
Clark, Yvonne +3 more
core +2 more sources