Results 31 to 40 of about 19,441 (231)
Scientific Reports, 2021 Preeclampsia (PE) is a severe multisystem pregnancy complication characterized by gestational hypertension and proteinuria. Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) is a mediator of mitophagy and has been proven to be associated with PE,
Xiaobo Zhou +6 more
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Cells, 2020 The Insulin-like Growth Factor I (IGF-1) signalling pathway is essential for cell growth and facilitates tumourogenic processes. We recently reported that IGF-1 induces a transcriptional programme for mitochondrial biogenesis, while also inducing ...
Sarah Riis +2 more
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BNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia
Cell Death and Disease, 2022 Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria.
Yun-Ling He +11 more
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BNIP3 in Lung Cancer: To Kill or Rescue? [PDF]
Cancers, 2020 Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes
Anna S. Gorbunova +3 more
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Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy. [PDF]
PLoS ONE, 2015 BNIP3 is a dual function protein, able to activate autophagy and induce cell death. Upon expression of BNIP3, which is upregulated by hypoxia, the protein induces mitochondrial dysfunction, often leading to cell death.
Katherine E Liu, William A Frazier
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Cells, 2019 : Stem cells isolated from the apical papilla of wisdom teeth (SCAPs) are an attractive model for tissue repair due to their availability, high proliferation rate and potential to differentiate in vitro towards mesodermal and neurogenic lineages.
Murielle Rémy +8 more
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BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria. [PDF]
PLoS ONE, 2012 Mieap, a p53-inducible protein, controls mitochondrial quality by repairing unhealthy mitochondria. During repair, Mieap induces the accumulation of intramitochondrial lysosomal proteins (designated MALM for Mieap-induced accumulation of lysosome-like ...
Yasuyuki Nakamura +7 more
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Hematology, 2023 Background: BCL2-interacting protein 3 (BNIP3) expression varies among cancers, and its role in myeloma cells remains unknown. We investigated the role of BNIP3 overexpression in myeloma cells, and particularly its effects on apoptosis and mitochondria ...
Pingping Xiao +7 more
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Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog [PDF]
Oncogene, 1998 We have identified a C. elegans protein, ceBNIP3, homologous to the human BCL-2/EIB-19K interacting BCL-2 family pro-apoptotic protein BNIP3. In transiently transfected mammalian cells, ceBNIP3 complexes with CED-9, the worm homolog of BCL-2. CeBNIP3 also efficiently heterodimerizes with the cell death protease proCED-3 by direct binding via the ...
M, Yasuda +3 more
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Cells, 2022 Previous work showed a role of BNIP3 in myocardial remodeling and progression to HFrEF. We utilized a multiomics approach to unravel BNIP3-related molecular mechanisms in the pathogenesis of HFrEF.
Antoine H. Chaanine +5 more
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