Results 31 to 40 of about 12,383 (188)
Cerebral Ischemic Preconditioning Aggravates Death of Oligodendrocytes
Biomolecules, 2022 Neurodegeneration can benefit from ischemic preconditioning, a natural adaptive reaction to sublethal noxious stimuli. Although there is growing interest in advancing preconditioning to preserve brain function, preconditioning is not yet considered ...
Teng Guan +7 more
doaj +1 more source
Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology.
PLoS ONE, 2015 Bnip3 is a hypoxia-regulated member of the Bcl-2 family of proteins that is implicated in apoptosis, programmed necrosis, autophagy and mitophagy. Mitochondria are thought to be the primary targets of Bnip3 although its activities may extend to the ER ...
John W Thompson +7 more
doaj +1 more source
Expression and Functional Characterization of the BNIP3 Protein in Renal Cell Carcinomas
Translational Oncology, 2017 BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1.
Stephan Macher-Goeppinger +6 more
doaj +1 more source
BNIP3 Upregulation Characterizes Cancer Cell Subpopulation With Increased Fitness and Proliferation
Frontiers in Oncology, 2022 BNIP3 is a BH3-only protein with both pro-apoptotic and pro-survival roles depending on the cellular context. It remains unclear how BNIP3 RNA level dictates cell fate decisions of cancer cells.
Yanyan Zhu +9 more
doaj +1 more source
BNIP3 promotes calcium and calpain-dependent cell death [PDF]
Life Sciences, 2015 Loss of cardiac muscle by programmed cell death contributes to the progression of ischemic heart disease. Hypoxia, metabolite waste buildup and energy depletion are components of ischemia which may initiate caspase dependent and independent cell death pathways.
Regina M, Graham +2 more
openaire +2 more sources
Regulation of Mitochondrial Integrity, Autophagy and Cell Survival by BNIP3 [PDF]
Autophagy, 2007 Understanding the role of BNIP3 in the systemic response to hypoxia has been complicated by conflicting results that indicate on the one hand that BNIP3 promotes cell death, and other data, including our own that BNIP3 is not sufficient for cell death, but rather plays a critical role in hypoxia-induced autophagy.
Kristin, Tracy, Kay F, Macleod
openaire +2 more sources
The ER membrane protein complex restricts mitophagy by controlling BNIP3 turnover
The EMBO Journal, 2023 Lysosomal degradation of autophagy receptors is a common proxy for selective autophagy. However, we find that two established mitophagy receptors, BNIP3 and BNIP3L/NIX, are constitutively delivered to lysosomes in an autophagy-independent manner.
Jose M Delgado +4 more
doaj +1 more source
BMC Cancer, 2009 Background Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a pro-apoptotic member of the Bcl-2 family induced under hypoxia. Low or absent expression has recently been described in human tumors, including gastrointestinal tumors, resulting ...
de Weger Roel A +5 more
doaj +1 more source
Cloning of BNIP3h, a member of proapoptotic BNIP3 family genes [PDF]
Experimental & Molecular Medicine, 2001 Apoptosis is regulated by interaction of antiapoptotic Bcl-2 family proteins with various proapoptotic proteins, several of which are also members of the Bcl-2 family. BNIP3 (formerly NIP3) is a proapoptotic mitochondrial protein classified in the Bcl-2 family based on limited sequence homology-3 (BH3) domain and COOH-terminal transmembrane domain ...
M, Farooq +7 more
openaire +2 more sources
Endocrine Regulations, 2020 Objective. The aim of the present study was to investigate the effect of adipokine NAMPT (nicotinamide phosphoribosyltransferase) silencing on the expression of genes encoding IRS1 (insulin receptor substrate 1) and some other proliferation related ...
Tsymbal Daria O. +5 more
doaj +1 more source