HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation [PDF]
Cell Stress, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao +4 more
doaj +5 more sources
BNIP3 in melanoma: isn’t it IRONic? [PDF]
Molecular & Cellular Oncology, 2021 Melanoma cells exploit mitophagy and hypoxia signaling to promote their growth. In a recent study, we found that loss of B-cell lymphoma 2 (BCL-2)/adenovirus E1B 19kDa protein-interacting protein 3 (BNIP3) curbed Hypoxia Inducible Factor 1 alpha (HIF-1α)
Mónica Vara-Pérez, Patrizia Agostinis
doaj +3 more sources
ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3 [PDF]
Scientific Reports, 2021 UNC51-like kinase-1 (ULK1) is the catalytic component of the autophagy pre-initiation complex that stimulates autophagy via phosphorylation of ATG14, BECLN1 and other autophagy proteins.
Logan P. Poole +3 more
doaj +4 more sources
Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features [PDF]
BMC Cancer, 2009 Background Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a pro-apoptotic member of the Bcl-2 family induced under hypoxia. Low or absent expression has recently been described in human tumors, including gastrointestinal tumors, resulting ...
de Weger Roel A +5 more
doaj +2 more sources
BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton [PDF]
Cell Death and Disease, 2014 BNIP3 is an atypical BH3-only member of the BCL-2 family of proteins with reported pro-death as well as pro-autophagic and cytoprotective functions, depending on the type of stress and cellular context.
Dmitri V Krysko +2 more
exaly +3 more sources
Tumor suppressor functions of BNIP3 and mitophagy [PDF]
Autophagy, 2015 There is a growing realization that tumor cells rely on healthy mitochondria to promote their growth under changing microenvironmental stresses and do so by dynamically modulating both their mitochondrial mass and state of mitochondrial fusion. Our recent work adds to this appreciation by showing that the mitophagy receptor BNIP3 functions as a tumor ...
Kay F Macleod
exaly +3 more sources
BNip3 regulates mitochondrial function and lipid metabolism in the liver [PDF]
Molecular and Cellular Biology, 2012 BNip3 localizes to the outer mitochondrial membrane, where it functions in mitophagy and mitochondrial dynamics. While the BNip3 protein is constitutively expressed in adult liver from fed mice, we have shown that its expression is superinduced by ...
Beaton, Michelle +9 more
core +6 more sources
Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death [PDF]
Autophagy, 2012 Hypoxia-inducible pro-death protein BNIP3 (BCL-2/adenovirus E1B 19-kDa interacting protein 3), provokes mitochondrial permeabilization causing cardiomyocyte death in ischemia-reperfusion injury.
Haiyan Liu, Abhinav Diwan
exaly +3 more sources
EIF4A3-Induced circ-BNIP3 Aggravated Hypoxia-Induced Injury of H9c2 Cells by Targeting miR-27a-3p/BNIP3 [PDF]
Molecular Therapy - Nucleic Acids, 2020 Acute myocardial infarction (AMI) results from long-term diminished blood supply diminishment (ischemia) to the heart, and the main reason for ischemia is hypoxia. BCL2 interaction protein 3 (BNIP3) can be upregulated by hypoxia and participates in the mediation of hypoxia-activated apoptosis in cardiac myocyte death.
Li, Yansong +4 more
exaly +3 more sources
Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover [PDF]
Cell Death and Differentiation, 2010 Bnip3 (Bcl-2/adenovirus E1B 19-kDa-interacting protein 3) is a mitochondrial BH3-only protein that contributes to cell death through activation of the mitochondrial pathway of apoptosis. Bnip3 is also known to induce autophagy, but the functional role of autophagy is unclear.
Anne Murphy, Åsa B Gustafsson
exaly +3 more sources