Results 11 to 20 of about 13,811 (214)

BNIP3 in melanoma: isn’t it IRONic? [PDF]

Molecular & Cellular Oncology, 2021
Melanoma cells exploit mitophagy and hypoxia signaling to promote their growth. In a recent study, we found that loss of B-cell lymphoma 2 (BCL-2)/adenovirus E1B 19kDa protein-interacting protein 3 (BNIP3) curbed Hypoxia Inducible Factor 1 alpha (HIF-1α)
Mónica Vara-Pérez, Patrizia Agostinis
doaj   +4 more sources

TAp73 transcriptionally represses BNIP3 expression [PDF]

Cell Cycle, 2015
TAp73 is a tumor suppressor transcriptional factor, belonging to p53 family. Alteration of TAp73 in tumors might lead to reduced DNA damage response, cell cycle arrest and apoptosis.
Barlev, NA, Knight, Richard A, Margherita Annicchiarico-Petruzzelli (735920), Amelio, I, Knight, RA, MELINO, GENNARO, Knight, Richard A., Petrova, V, Amelio, I., Nikolai A Barlev (776101), Agostini, M, Mancini, Mara, Annicchiarico Petruzzelli, M, Annicchiarico-Petruzzelli, M, Richard A Knight (776100), Ivano Amelio (735923), Petrova, Varvara, Massimiliano Agostini (735918), Varvara Petrova (735916), Mancini, M, Melino, G, Gerry Melino (735922), Agostini, Massimiliano, Annicchiarico-Petruzzelli, Margherita, Mara Mancini (735917), Barlev, Nikolai A., Amelio, Ivano, Barlev, Nikolai A, Melino, Gerry   +28 more
core   +5 more sources

BNIP3 expression in follicular lymphoma.

Histopathology, 2007
AIMS: To investigate the role of BNIP3, a 19-kDa interacting protein of the Bcl-2 family, alongside Bcl-2 in follicular lymphoma in comparison with reactive lymphoid hyperplasia.
Campo, L, K C Gatter, F Pezzella, L Campo, Gatter, KC, J Sington, A Giatromanolaki, Turley, H, Pezzella, Francesco, Sington, J, Pezzella, F, H Turley, Giatromanolaki, A   +12 more
core   +3 more sources

Role of BNIP3 in TNF-induced cell death - TNF upregulates BNIP3 expression

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Tumor necrosis factor alpha (TNF) is a cytokine that induces caspase-dependent (apoptotic) and caspase-independent (necrosis-like) cell death in different cells.
Ghavami, Saeid, Kadkhoda, Kamran, Mutawe, Mark M., Eshraghi, Mehdi,, Ghavami, Saeid,, Halayko, Andrew J.,, Klonisch, Thomas,, Eshraghi, Mehdi, Los, Marek Jan,, Wesselborg, Sebastian, Mutawe, Mark M.,, Klonisch, Thomas, Wesselborg, Sebastian,, Halayko, Andrew J., Los, Marek, Maddika, Subbareddy,, Los, Marek Jan, Kadkhoda, Kamran,, Bay, Graham H.,, Maddika, Subbareddy, Bay, Graham H.   +20 more
core   +4 more sources

ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3 [PDF]

Scientific Reports, 2021
UNC51-like kinase-1 (ULK1) is the catalytic component of the autophagy pre-initiation complex that stimulates autophagy via phosphorylation of ATG14, BECLN1 and other autophagy proteins.
Logan P. Poole, Althea Bock-Hughes, Damian E. Berardi, Kay F. Macleod   +3 more
doaj   +4 more sources

BNIP3 in Lung Cancer: To Kill or Rescue? [PDF]

Cancers, 2020
Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons.
Boris Zhivotovsky, Maria A. Yapryntseva, Anna S. Gorbunova, Tatiana V. Denisenko, Yapryntseva, MA, Gorbunova, AS, Denisenko, TV, Zhivotovsky, B,   +7 more
core   +3 more sources

BNIP3 Downregulation Ameliorates Muscle Atrophy in Cancer Cachexia [PDF]

Cancers
Background and aims: Cancer cachexia is a complex syndrome affecting most cancer patients and is directly responsible for about 20% of cancer-related deaths.
Penna, Fabio, Fornelli, Claudia, Sebastián Muñoz, David, Zorzano Olarte, Antonio, Beltrà, Marc, Costelli, Paola   +5 more
core   +5 more sources

Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy. [PDF]

PLoS ONE, 2015
BNIP3 is a dual function protein, able to activate autophagy and induce cell death. Upon expression of BNIP3, which is upregulated by hypoxia, the protein induces mitochondrial dysfunction, often leading to cell death.
Katherine E Liu, William A Frazier
doaj   +3 more sources

Functions of BNIP3 in Nutrient Stress Responses [PDF]

, 2019
BNIP3 is a mitophagy receptor that targets mitochondria for degradation at the autophagolysosome. By mediating mitophagy, BNIP3 functions to decrease mitochondrial mass as an adaptive response to stress, namely hypoxia and nutrient starvation.
Springer, Maya Zafrir
core   +2 more sources

BNip3 and signal-specific programmed death in the heart

Journal of Molecular and Cellular Cardiology, 2005
The BH3-only proteins, including BNip3, are members of the Bcl-2 family of cell death-regulating factors. Whereas proteins such as Bax and Bak play a central role in most forms of apoptosis, the BH3-only proteins appear to modulate apoptosis through cell
Webster, Keith A, Graham, Regina M, Bishopric, Nanette H   +2 more
core   +3 more sources