Results 71 to 80 of about 13,811 (214)

BNIP3 as a new tool to promote healthy brain aging

Aging Cell, 2023
AbstractThe article “Neuronal induction of BNIP3‐mediated mitophagy slows systemic aging in Drosophila” reveals BCL2‐interacting protein 3 as a therapeutic target to counteract brain aging and prolong overall organismal health with age. In this spotlight, we consider the roles of BNIP3, a mitochondrial outer membrane protein, in the adult nervous ...
Kit Neikirk, Andrea G. Marshall, Monica M. Santisteban, Antentor Hinton   +3 more
openaire   +2 more sources

BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy

Cell Death and Disease, 2022
Autophagy-mediated mitochondrial degradation plays pivotal roles in both the acquisition and maintenance of pluripotency, but the molecular mechanisms that link autophagy-mediated mitochondrial homeostasis to pluripotency regulation are unclear. Here, we
Kun Liu, Qian Zhao, Hongyan Sun, Lei Liu, Chaoqun Wang, Zheng Li, Youqing Xu, Liang Wang, Lin Zhang, Honghai Zhang, Quan Chen, Tongbiao Zhao   +11 more
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

The Regulatory Role and Mechanism of Myoferlin in Mitophagy During Papillary Thyroid Carcinogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Papillary thyroid carcinoma (PTC) is the most prevalent subtype of thyroid cancer; however, the regulatory mechanisms by which mitophagy influences its progression remain inadequately elucidated. This study sought to examine the role of myoferlin (MYOF) in mitophagy and its molecular basis during PTC development. Utilizing three paired PTC and
Wen‐Chao Lyu, Yang‐Shuai Wang, Chun‐Yang Shang, Ming Qi, Tong‐Chang Li, Li‐Xin Lian, Hai‐Quan Qiao   +6 more
wiley   +1 more source

Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study

Journal of Translational Medicine, 2012
Background This study was designed to determine the pattern and correlation between expression of the HIF-1α transcriptional targets TGM2 and BNIP3 in laryngeal cancer, and investigate the association of BNIP3 and TGM2 with clinical outcome in laryngeal ...
Jin Ting, Lin Huan-Xin, Lin Hui, Guo Li-Bing, Ge Nan, Cai Xiu-Yu, Sun Rui, Chen Wen-Kuan, Li Qiu-Li, Hu Wei-Han   +9 more
doaj   +1 more source

The Allium cepa Derived Compound Propyl Propane Thiosulfonate (PTSO) Improves Tumorigenesis Due to Its Immunomodulatory Effect: A Preclinical Study

Phytotherapy Research, EarlyView.
In vitro and in vivo effects of PTSO in colorectal cancer preclinical models, highlighting antiproliferative, pro‐apoptotic, barrier‐enhancing, antitumor, prebiotic and immunomodulatory properties. Created using BioRender. ABSTRACT Allium‐derived organosulfur compounds offer significant health benefits.
María Jesús Rodríguez‐Sojo, Laura Hidalgo‐García, Jose Alberto Molina‐Tijeras, Laura López‐Escanez, Luckman Gbati, Teresa Vezza, Patricia Diez‐Echave, Antonio Jesús Ruiz‐Malagón, Jorge García‐García, Federico García, Alberto Baños, Lidia Gil‐Martínez, Rocío López‐Posadas, Markus F. Neurath, Julio Gálvez, María Elena Rodríguez‐Cabezas, Alba Rodríguez‐Nogales   +16 more
wiley   +1 more source

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

C-terminal BNIP3 phosphorylation inhibits BNIP3-induced loss of mitochondrial function.

, 2015
(A) Representative examples of JC1 dual color fluorescence, examined by confocal microscopy. Red JC1 fluorescence is localized to polarized mitochondria whereas green fluorescence is independent of membrane polarization. Scale bar represents 10 μm.
William A. Frazier (759144), Katherine E. Liu (759143)   +1 more
core   +1 more source

Dual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX

Life Science Alliance
The mitochondrial phosphatase PPTC7 was previously found to suppress mitophagy, but the underlying mechanisms were unclear. Here, the authors show that PPTC7 dynamically localizes to the outer mitochondrial membrane to promote the turnover of the ...
Lianjie Wei, Mehmet Oguz Gok, Jordyn D Svoboda, Keri-Lyn Kozul, Merima Forny, Jonathan R Friedman, Natalie M Niemi   +6 more
doaj   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source