Results 91 to 100 of about 12,383 (188)

PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy

Cell Death and Disease
Mitophagy is a selective process that targets the damaged, dysfunctional, or superfluous mitochondria for degradation through autophagy. The SCFFBXL4 E3 ubiquitin ligase complex suppresses basal mitophagy by targeting BNIP3 and BNIP3L, two key mitophagy ...
Xiayun Xu, Yingji Chen, Siqi Fei, Xinyue Jiang, Xiaoting Zhou, Yimeng Xue, Yao Li, Shi-Min Zhao, Yan Huang, Chenji Wang   +9 more
doaj   +1 more source

BNIP3 Downregulation Ameliorates Muscle Atrophy in Cancer Cachexia

Cancers
Background and Aims: Cancer cachexia is a complex syndrome affecting most cancer patients and is directly responsible for about 20% of cancer-related deaths. Previous studies showed muscle proteolysis hyper-activation and mitophagy induction in tumor-bearing animals.
Claudia Fornelli, Marc Beltrà, Antonio Zorzano, Paola Costelli, David Sebastian, Fabio Penna   +5 more
openaire   +3 more sources

Purification of BNIP3-GFP v1

This protocol details the purification of BNIP3-GFP.
openaire   +1 more source

Coordinating BNIP3/NIX-mediated mitophagy in space and time

Biochemical Society Transactions
Mitochondria maintain organellar homeostasis through multiple quality control pathways, including the clearance of defective or unwanted mitochondria by selective autophagy. This removal of mitochondria, mitophagy, is controlled in large part by the outer mitochondrial membrane mitophagy receptors BNIP3 and NIX.
Natalie M. Niemi, Jonathan R. Friedman
openaire   +2 more sources

BNIP3-dependent mitophagy role in cisplatin resistance

Autophagy Reports, 2022
Cocetta V., Vianello C., Giacomello M., Montopoli M.   +3 more
openaire   +3 more sources

Overexpression of BNIP3 in renal carcinoma cells can promote apoptosis of renal carcinoma cells through HIF-1α-BNIP3-mediated autophagy

Frontiers in Oncology
BackgroundRenal cell carcinoma (RCC) is a prevalent malignancy with limited effective therapies, necessitating novel molecular targets. BNIP3, a pro-apoptotic protein regulated by hypoxia-inducible factor 1 (HIF-1), is implicated in autophagy and ...
Long Huang, Lin Wang, Dan Yuan, Yan Xu, Yu Wang, Kai Yao, Xiao Zhong, Quanda Liu, Kang Jia, Lei Lei, Haiyan Wang, Dongliang Liu   +11 more
doaj   +1 more source

KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells

Cellular & Molecular Biology Letters
Background Differentiating dental pulp stem cells (DPSCs) into odontoblasts is a critical process for tooth self-repair and dentine‒pulp engineering strategies in the clinic.
Zeying Zhang, Di Yang, Xiaoyuan Yan, Qiujing Qiu, Jiajie Guo, Lihong Qiu   +5 more
doaj   +1 more source

HIF1A/BNIP3 pathway affects ferroptosis in sepsis-induced cardiomyopathy through binding to BCL-2

Redox Report
Background: Sepsis-induced cardiomyopathy (SIC) involves ferroptosis, an iron-dependent cell death. Hypoxia-inducible factor-1α (HIF-1α) regulates autophagy and apoptosis, but its role in ferroptosis remains unclear.
Xiaoyue Wang, Jinze Li, Yixin Zhang, Ming huang, Pengqiang Yang, Tianwen Huang, Qinghong Cheng   +6 more
doaj   +1 more source

BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome

Frontiers in Immunology
IntroductionPreeclampsia (PE) is a hypertensive disorder of pregnancy characterized by pronounced placental oxidative stress and inflammatory damage. However, the contribution of mitophagy to inflammation-induced placental injury in PE remains unclear ...
Man Zhao, Zexin Yang, Yan Kang, Zhenya Fang, Changqing Zhang, Chunying Wang, Meijuan Zhou, Junjun Guo, Anna Li, Meihua Zhang   +9 more
doaj   +1 more source

BNIP3 IN MELANOMA: SITTING ON THE IRON THRONE Unraveling the role of BNIP3 in mitochondrial homeostasis, metabolism and melanoma growth

, 2021
Melanoma is the deadliest form of skin cancer due to its ability to metastasize rapidly and to become resistant to various forms of therapies. To support their aggressive phenotype, melanoma cells require metabolic plasticity, which they acquire by hijacking key adaptive responses like the hypoxia-inducible response and autophagy.
openaire   +1 more source