Results 111 to 120 of about 13,811 (214)
BNIP3 Phosphorylation is a Switch that Regulates Autophagy and Cell Death
, 2015 BNIP3 has a well-established role in triggering mitochondrial damage and cell death, as well as activating autophagy. Upon localizing to the outer mitochondrial membrane, BNIP3 induces mitochondrial depolarization, which can lead to cell death.
Liu, Katherine
core +1 more source
BNIP3 induces mitophagy in WT and PINK1-/- myocytes.
, 2015 (A) Representative fluorescent images of WT and PINK1-/- adult mouse cardiac myocytes overexpressing GFP-LC3 and either β-gal or BNIP3. (B) The percentage of cells with activated autophagy significantly increased in both WT and PINK1-/- cells in response
Rita H. Najor (760805) +5 more
core +1 more source
BNIP3-dependent mitophagy role in cisplatin resistance
Autophagy Reports, 2022 Cocetta V. +3 more
openaire +3 more sources
Frontiers in OncologyBackgroundRenal cell carcinoma (RCC) is a prevalent malignancy with limited effective therapies, necessitating novel molecular targets. BNIP3, a pro-apoptotic protein regulated by hypoxia-inducible factor 1 (HIF-1), is implicated in autophagy and ...
Long Huang +11 more
doaj +1 more source
Bnip3 interacts with LC3 to induce selective removal of endoplasmic reticulum and mitochondria via autophagy [PDF]
, 2011 Bcl-2 family proteins are known to regulate mitochondrial integrity and apoptosis. More recently, they have been found to play a role in regulating autophagy. Autophagy is a process involved in removing excess or damaged organelles.
Hanna, Rita Akram
core
MOESM2 of Testosterone induces renal tubular epithelial cell death through the HIF-1Îą/BNIP3 pathway
, 2019 Additional file 2: Figure S2. BNIP3 siRNA efficiency. To validate the BNIP3 siRNA knockdown efficiency, we detected the BNIP3 mRNA (A) and protein (B) level. Compared to the negative control siRNA group, BNIP3 siRNA significantly decreased BNIP3 mRNA and
Ziyu Fang (6413651) +15 more
core +1 more source
HIF1A/BNIP3 pathway affects ferroptosis in sepsis-induced cardiomyopathy through binding to BCL-2
Redox ReportBackground: Sepsis-induced cardiomyopathy (SIC) involves ferroptosis, an iron-dependent cell death. Hypoxia-inducible factor-1α (HIF-1α) regulates autophagy and apoptosis, but its role in ferroptosis remains unclear.
Xiaoyue Wang +6 more
doaj +1 more source
BNIP3 regulates AT101-induced cytotoxicity in MPNST cells.
, 2014 AT101 treated MPNST cells show a concentration-dependent increase in BNIP3 protein on western blot (A) and immunocytochemistry (B). AT101 treatment causes a significant increase in BNIP3 mRNA in MPNST cells compared to untreated cells (C).
Steven L. Carroll (563601) +5 more
core +1 more source
, 2021 Melanoma is the deadliest form of skin cancer due to its ability to metastasize rapidly and to become resistant to various forms of therapies. To support their aggressive phenotype, melanoma cells require metabolic plasticity, which they acquire by hijacking key adaptive responses like the hypoxia-inducible response and autophagy.
openaire +1 more source
Cellular & Molecular Biology LettersBackground Differentiating dental pulp stem cells (DPSCs) into odontoblasts is a critical process for tooth self-repair and dentine‒pulp engineering strategies in the clinic.
Zeying Zhang +5 more
doaj +1 more source