Results 131 to 140 of about 19,441 (231)

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain [PDF]

, 2017
Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells.
Chen, Jia-Li, Qin, Zheng-Hong, Sheng, Rui, Song, Dan-Dan, Waeber, Christian, Xia, Yun-Fei, Zhang, Tong-Tong   +6 more
core   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia [PDF]

, 2016
Representative flow cytometric plots (FACS) showing that AMSCs expressed HLA-ABC, CD44, CD90, CD29, CD73, and CD105 markers, and did not express HLA-DR, CD45, CD14 or CD34 markers.
Ahmed Saad, Allan B. Dietz, Andre J. van Wijnen, Hui Tang, LaTonya Hickson, Lilach Lerman, Sandra Herrmann, Stephen Textor, Xiang-Yang Zhu   +8 more
core   +3 more sources

FAM162A Is a Key Regulator of Mitochondrial Structure, Dynamics, and Bioenergetics, Driving Cellular Protection and Longevity

Aging Cell, Volume 25, Issue 5, May 2026.
FAM162A, localized within mitochondrial cristae, emerges as a novel regulator of mitochondrial dynamics. It post‐translationally modulates OPA1, maintaining cristae structure and boosting cellular bioenergetics. This key interaction enhances cell viability, stress resistance, and overall organismal health.
Andrea Matamoros, Juan Pablo Soffia, Marcelo Muñoz, Michael Maturana, Ma Andreina Rangel‐Ramirez, Alvaro Gonzalez‐Ibañez, Gabriela Gómez‐Lillo, Cesar Astorga, Lina M. Ruiz, Ramón A. Jorquera, Alejandra San Martín, Alvaro A. Elorza   +11 more
wiley   +1 more source

Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation

BMC Neuroscience, 2009
Background Caspase-independent apoptotic pathways are suggested as a mechanism for the delayed neuronal death following ischemic insult. However, the underlying signalling mechanisms are largely unknown.
Bean Jonathan C, Das Manas, Li Bo-Xing, Zhang Ming-Hai, Li Shu-Ji, Chen Ming, Zhao Shen-Ting, Kong Ji-Ming, Zhu Xin-Hong, Gao Tian-Ming   +9 more
doaj   +1 more source

Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma [PDF]

, 2011
Background The molecular mechanisms of CC (cholangiocarcinoma) oncogenesis and progression are poorly understood. This study aimed to determine the genome-wide expression of genes related to CC oncogenesis and sarcomatous transdifferentiation.
Min-A Seol, In-Sun Chu, Mi-Jin Lee, Goung-Ran Yu, Xiang-Dan Cui, Baik-Hwan Cho, Eun-Kyung Ahn, Sun-Hee Leem, In-Hee Kim, Dae-Ghon Kim   +9 more
core   +1 more source

Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015
Mitochondrial autophagy (mitophagy) is a core cellular activity. In this review, we consider mitophagy and related cellular processes and discuss their significance for human disease. Strong parallels exist between mitophagy and xenophagy employed in host defense. These mechanisms converge on receptors in the innate immune system in clinically relevant
openaire   +2 more sources

BNIP3‐Dependent Mitophagy Non‐Autonomously Regulates Systemic Aging via NF‐κB Suppression in Drosophila

Aging Cell, Volume 25, Issue 5, May 2026.
Muscle aging is characterized by alterations in mitochondrial morphology and structure, leading to the accumulation of reactive oxygen species (ROS). This increase in ROS activates Key/Relish‐mediated inflammatory pathways, resulting in the production of antimicrobial peptides (AMPs) that further accelerate aging.
Zhouyang Deng, Hailong Han, Caifang Wang, Wen Zhong, Zhengqing Wan, Dan Zhou, Ye Chen, Yanni Peng, Zongzhao Zhai, Kai Yuan, Ruoxi Wang, Zhuohua Zhang   +11 more
wiley   +1 more source

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]

, 2017
Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S., Chatterjee, U., Ganguly, G., Saso, L.   +3 more
core   +3 more sources

Mitophagy‐Oxidative Stress Molecular Subtypes Define an Immunosuppressive Ecosystem and Vulnerabilities in Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumour with an immunosuppressive environment and poor prognosis; however, the roles of mitophagy and oxidative stress in its prognosis remain underexplored. This study analysed multi‐omics data from TCGA‐GBM (n = 168) and two GEO cohorts (GSE43378, n = 50; GSE147352, n = 85), compiling 603 mitophagy ...
Changjiang He, Yang Wang, Hongliang Zhong   +2 more
wiley   +1 more source