Results 151 to 160 of about 19,441 (231)

Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis. [PDF]

, 2020
Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis.
Cuevas-Mora, Karina, Romero, Freddy, Roque, Willy   +2 more
core   +1 more source

Overexpression of BNIP3 in renal carcinoma cells can promote apoptosis of renal carcinoma cells through HIF-1α-BNIP3-mediated autophagy

Frontiers in Oncology
BackgroundRenal cell carcinoma (RCC) is a prevalent malignancy with limited effective therapies, necessitating novel molecular targets. BNIP3, a pro-apoptotic protein regulated by hypoxia-inducible factor 1 (HIF-1), is implicated in autophagy and ...
Long Huang, Lin Wang, Dan Yuan, Yan Xu, Yu Wang, Kai Yao, Xiao Zhong, Quanda Liu, Kang Jia, Lei Lei, Haiyan Wang, Dongliang Liu   +11 more
doaj   +1 more source

BNIP3-dependent mitophagy role in cisplatin resistance

Autophagy Reports, 2022
Cocetta V., Vianello C., Giacomello M., Montopoli M.   +3 more
openaire   +3 more sources

HIF1A/BNIP3 pathway affects ferroptosis in sepsis-induced cardiomyopathy through binding to BCL-2

Redox Report
Background: Sepsis-induced cardiomyopathy (SIC) involves ferroptosis, an iron-dependent cell death. Hypoxia-inducible factor-1α (HIF-1α) regulates autophagy and apoptosis, but its role in ferroptosis remains unclear.
Xiaoyue Wang, Jinze Li, Yixin Zhang, Ming huang, Pengqiang Yang, Tianwen Huang, Qinghong Cheng   +6 more
doaj   +1 more source

BNIP3 IN MELANOMA: SITTING ON THE IRON THRONE Unraveling the role of BNIP3 in mitochondrial homeostasis, metabolism and melanoma growth

, 2021
Melanoma is the deadliest form of skin cancer due to its ability to metastasize rapidly and to become resistant to various forms of therapies. To support their aggressive phenotype, melanoma cells require metabolic plasticity, which they acquire by hijacking key adaptive responses like the hypoxia-inducible response and autophagy.
openaire   +1 more source

KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells

Cellular & Molecular Biology Letters
Background Differentiating dental pulp stem cells (DPSCs) into odontoblasts is a critical process for tooth self-repair and dentine‒pulp engineering strategies in the clinic.
Zeying Zhang, Di Yang, Xiaoyuan Yan, Qiujing Qiu, Jiajie Guo, Lihong Qiu   +5 more
doaj   +1 more source

Purification of BNIP3-GFP v1

This protocol details the purification of BNIP3-GFP.
openaire   +1 more source

BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome

Frontiers in Immunology
IntroductionPreeclampsia (PE) is a hypertensive disorder of pregnancy characterized by pronounced placental oxidative stress and inflammatory damage. However, the contribution of mitophagy to inflammation-induced placental injury in PE remains unclear ...
Man Zhao, Zexin Yang, Yan Kang, Zhenya Fang, Changqing Zhang, Chunying Wang, Meijuan Zhou, Junjun Guo, Anna Li, Meihua Zhang   +9 more
doaj   +1 more source

Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment. [PDF]

, 2019
Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment.
Fan, Li, Feng, Jianbo, Fu, Haijuan, Li, Guiyuan, Li, Peiyao, Liu, Changhong, Liu, Qiang, Liu, Qing, Ren, Xing, She, Xiaoling, Sun, Yingnan, Wu, Minghua, Zhang, Yan, Zhao, Chunhua   +13 more
core   +1 more source

Purification of BNIP3-GST v1

This protocol details the purification of BNIP3-GST.
openaire   +1 more source