Results 151 to 160 of about 12,383 (188)

Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1. [PDF]

Nat Commun
Park SY, Son K, Kim J, Kim K, Joo S, Kim B, Lee M, Kim W, Jung WJ, Choi BK, Jeon N, Chung WY, Hu Y, Lee H, Song NY.   +14 more
europepmc   +1 more source

Copper deficiency impairs oligodendrocyte maturation and social behavior via mitophagy and mTOR suppression in ASD. [PDF]

Sci Adv
Usui N, Doi M, Berto S, Matsuoka K, Ishida R, Miyauchi H, Fujiwara Y, Irie K, Toritsuka M, Yamauchi T, Hirai T, Xie MJ, Kayashima Y, Umeda N, Iwata K, Okumura K, Harada T, Katayama T, Tsujii M, Matsuzaki H, Makinodan M, Shimada S.   +21 more
europepmc   +1 more source

PANoptosis-Related Diagnostic Biomarkers in Non-Neovascular Age-Related Macular Degeneration: An Integrative Transcriptomic and Experimental Study. [PDF]

Genet Res (Camb)
Li J, Ma Y, Hu M, Zhang Q, Wang A, Tang Q, Guo Q, Huang B.   +7 more
europepmc   +1 more source

Physiological cerebrospinal fluid like medium reveals autophagy dependency of leukaemia in the central nervous system

Himonas E, Manoharan A, Roy K, Rattigan KM, Ianniciello A, Zarou MM, Sarnello D, Martin L, Shoemaker R, Sumpton D, Tardito S, Halsey C, Helgason GV.   +12 more
europepmc   +1 more source

BNIP3 in Lung Cancer: To Kill or Rescue? [PDF]

Cancers, 2020
Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes
Boris Zhivotovsky, Anna Gorbunova, Zhivotovsky Boris   +2 more
exaly   +3 more sources

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BNIP3 as a Regulator of Cisplatin-Induced Apoptosis

Biochemistry (Moscow), 2020
BNIP3 is a member of Bcl-2 protein family involved in regulation of various forms of cell death. However, its role in these processes remains unclear and varies depending on the type of cancer cells and environmental factors (pH, O2 level, etc.). Here, the role of BNIP3 in apoptosis regulation in lung adenocarcinoma cells was investigated.
A S, Gorbunova, T V, Denisenko, M A, Yapryntseva, A D, Pivnyuk, T A, Prikazchikova, V G, Gogvadze, B, Zhivotovsky   +6 more
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BNIP3 and Nix: Atypical regulators of cell fate

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022
Since their discovery nearly 25 years ago, the BCL-2 family members BNIP3 and BNIP3L (aka Nix) have been labelled 'atypical'. Originally, this was because BNIP3 and Nix have divergent BH3 domains compared to other BCL-2 proteins. In addition, this atypical BH3 domain is dispensable for inducing cell death, which is also unusual for a 'death gene ...
Jared T, Field, Joseph W, Gordon
openaire   +2 more sources

BNip3 and signal-specific programmed death in the heart

Journal of Molecular and Cellular Cardiology, 2005
The BH3-only proteins, including BNip3, are members of the Bcl-2 family of cell death-regulating factors. Whereas proteins such as Bax and Bak play a central role in most forms of apoptosis, the BH3-only proteins appear to modulate apoptosis through cell type- and signal-specific pathways.
Regina Graham, Keith A Webster
exaly   +3 more sources

EIF4A3-Induced circ-BNIP3 Aggravated Hypoxia-Induced Injury of H9c2 Cells by Targeting miR-27a-3p/BNIP3 [PDF]

Molecular Therapy - Nucleic Acids, 2020
Acute myocardial infarction (AMI) results from long-term diminished blood supply diminishment (ischemia) to the heart, and the main reason for ischemia is hypoxia. BCL2 interaction protein 3 (BNIP3) can be upregulated by hypoxia and participates in the mediation of hypoxia-activated apoptosis in cardiac myocyte death.
Li, Yansong, Ren, Shuhong, Xia, Jingwen, Wei, Yong, Xi, Yinhua   +4 more
exaly   +3 more sources

BNIP3 Regulation of Intracellular Calcium

The FASEB Journal, 2016
Necrotizing enterocolitis is the most common gastrointestinal emergency affecting low‐birth weight premature infants, with an incidence between 3% and 10% in infants less than 1500 grams, and mortality ranging from 15% to 30%. The pathogenesis of NEC is not clearly defined, but is likely a multifactorial disease wherein intestinal ischemia and hypoxia ...
Jared Field, Simone da Silva Rosa, Wajihah Mughal, Yan Hai, Joseph Gordon, William L Diehl‐Jones   +5 more
openaire   +1 more source