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Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover [PDF]

Cell Death and Differentiation, 2010
Bnip3 (Bcl-2/adenovirus E1B 19-kDa-interacting protein 3) is a mitochondrial BH3-only protein that contributes to cell death through activation of the mitochondrial pathway of apoptosis. Bnip3 is also known to induce autophagy, but the functional role of autophagy is unclear.
Asa Gustafsson, Anne N Murphy
exaly   +3 more sources

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An unexpected journey for BNIP3

Autophagy
Mitophagy is a cellular process that enables the selective degradation of damaged, dysfunctional, or superfluous mitochondria. During mitophagy, specific proteins recognize and tag mitochondria for degradation. These tagged mitochondria are engulfed by specialized structures called phagophores that then mature into autophagosomes/mitophagosomes ...
José M Delgado, Christopher J Shoemaker
openaire   +2 more sources

Role of BNIP3 and NIX in cell death, autophagy, and mitophagy [PDF]

Cell Death and Differentiation, 2009
BNIP3 and NIX are proteins related to the BH3-only family, which induce both cell death and autophagy. Consistent with their ability to induce cell death, BNIP3 and NIX are implicated in the pathogenesis of cancer and heart disease. In tumor cells, BNIP3 and NIX are regulated by hypoxia, and the deregulation of BNIP3 or NIX expression is associated ...
J, Zhang, P A, Ney
exaly   +3 more sources

Structural Basis for Dimerization of the BNIP3 Transmembrane Domain^,

Biochemistry, 2009
Mutagenesis data suggest that BNIP3 transmembrane domain dimerization depends critically on hydrogen bonding between His 173 and Ser 172, but a recent structural analysis indicates that these residues adopt multiple conformations and are not always hydrogen bonded.
Endah S, Sulistijo, Kevin R, Mackenzie
openaire   +2 more sources

Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3

Biochemical and Biophysical Research Communications, 2008
An angiogenic factor, thymidine phosphorylase (TP), confers resistance to apoptosis induced by hypoxia. We investigated the molecular basis for the suppressive effect of TP on hypoxia-induced apoptosis using Jurkat cells transfected with TP cDNA, Jurkat/TP, and a mock transfectant, Jurkat/CV.
Ryuji, Ikeda, Yusuke, Tajitsu, Ken-Ichi, Iwashita, Xiao-Fang, Che, Kenichi, Yoshida, Mina, Ushiyama, Tatsuhiko, Furukawa, Masaharu, Komatsu, Tatsuya, Yamaguchi, Yoshihiko, Shibayama, Masatatsu, Yamamoto, Hong-Ye, Zhao, Junko, Arima, Yasuo, Takeda, Shin-Ichi, Akiyama, Katsushi, Yamada   +15 more
openaire   +2 more sources

TUMOR SUPPRESSIVE FUNCTIONS OF BNIP3

2016
BNIP3 is a mitochondrial protein that targets mitochondria for autophagosomal degradation or mitophagy. It is induced under physiological stresses such as hypoxia and nutrient starvation and functions to eliminate damaged mitochondria in order to maintain the overall mitochondrial integrity of the cell.
openaire   +1 more source

Structure, function, and epigenetic regulation of BNIP3: a pathophysiological relevance

Molecular Biology Reports, 2014
BCL-2 [B-cell leukemia/lymphoma 2]/adenovirus E1B 19KD interacting protein 3 (BNIP3) is an atypical BH3 domain only containing member of Bcl2 family of proteins. BNIP3 is known to be involved in various cellular processes depending on the cell type and conditions and also shown to play a role in various disease conditions including myocardial ischemia,
Nagarjuna, Vasagiri, Vijay Kumar, Kutala
openaire   +2 more sources

BNip3 is a mediator of TNF-induced necrotic cell death

Apoptosis, 2010
Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in immune modulation, inflammatory reactions, and target cell death in many pathologic conditions. The cell death pathways triggered by TNF include the caspase-8/Bid-dependent apoptotic pathway and the caspase-independent necrosis pathway (necroptosis).
Jee-Youn, Kim, Yong-Jun, Kim, Sun, Lee, Jae-Hoon, Park   +3 more
openaire   +2 more sources

Hypoxia and expression of the proapoptotic regulator BNIP3 in cervical cancer

International Journal of Gynecological Cancer, 2006
Hypoxia plays a major role in the malignant progression of tumors. Here, we investigate the expression of Bcl-2/adenovirus E1B 19 kd-interacting protein 3 (BNIP3), a proapoptotic Bcl-2 family member, and its relationship to hypoxia in cervical cancer cell lines and clinical samples of cervical cancer. Cervical cancer cell lines were grown under hypoxia
C, Leo, L-C, Horn, M, Höckel
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Expression of the cell death genes BNip3 and NIX in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade

The Journal of Pathology, 2003
Abstract Ductal carcinoma in situ (DCIS) of the breast is an early, non‐invasive lesion and the prognosis is associated with the extent of necrosis and cell death within the tumour.
Heidi Michelle, Sowter, Mary, Ferguson, Caroline, Pym, Peter, Watson, Stephen B, Fox, Cheng, Han, Adrian L, Harris   +6 more
openaire   +2 more sources