Results 181 to 190 of about 13,811 (214)

Copper deficiency impairs oligodendrocyte maturation and social behavior via mitophagy and mTOR suppression in ASD. [PDF]

Sci Adv
Usui N, Doi M, Berto S, Matsuoka K, Ishida R, Miyauchi H, Fujiwara Y, Irie K, Toritsuka M, Yamauchi T, Hirai T, Xie MJ, Kayashima Y, Umeda N, Iwata K, Okumura K, Harada T, Katayama T, Tsujii M, Matsuzaki H, Makinodan M, Shimada S.   +21 more
europepmc   +1 more source

PANoptosis-Related Diagnostic Biomarkers in Non-Neovascular Age-Related Macular Degeneration: An Integrative Transcriptomic and Experimental Study. [PDF]

Genet Res (Camb)
Li J, Ma Y, Hu M, Zhang Q, Wang A, Tang Q, Guo Q, Huang B.   +7 more
europepmc   +1 more source

HMOX1 interacts with BNIP3 to modulate neuronal ferroptosis after spinal cord ischemia-reperfusion injury via a mitophagy-dependent mechanism. [PDF]

Cell Death Discov
Duan Y, Zhang Y, Yang F, Zhang M, Shi Y, Ma Z, Huang X, Li W, Lang Y, Hu X, Kang X.   +10 more
europepmc   +1 more source

Tumor suppressor functions of BNIP3 and mitophagy [PDF]

Autophagy, 2015
There is a growing realization that tumor cells rely on healthy mitochondria to promote their growth under changing microenvironmental stresses and do so by dynamically modulating both their mitochondrial mass and state of mitochondrial fusion. Our recent work adds to this appreciation by showing that the mitophagy receptor BNIP3 functions as a tumor ...
Kay F Macleod
exaly   +3 more sources

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BNIP3 and Nix: Atypical regulators of cell fate

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022
Since their discovery nearly 25 years ago, the BCL-2 family members BNIP3 and BNIP3L (aka Nix) have been labelled 'atypical'. Originally, this was because BNIP3 and Nix have divergent BH3 domains compared to other BCL-2 proteins. In addition, this atypical BH3 domain is dispensable for inducing cell death, which is also unusual for a 'death gene ...
Jared T, Field, Joseph W, Gordon
openaire   +2 more sources

BNIP3 as a Regulator of Cisplatin-Induced Apoptosis

Biochemistry (Moscow), 2020
BNIP3 is a member of Bcl-2 protein family involved in regulation of various forms of cell death. However, its role in these processes remains unclear and varies depending on the type of cancer cells and environmental factors (pH, O2 level, etc.). Here, the role of BNIP3 in apoptosis regulation in lung adenocarcinoma cells was investigated.
A S, Gorbunova, T V, Denisenko, M A, Yapryntseva, A D, Pivnyuk, T A, Prikazchikova, V G, Gogvadze, B, Zhivotovsky   +6 more
openaire   +2 more sources

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover [PDF]

Cell Death and Differentiation, 2010
Bnip3 (Bcl-2/adenovirus E1B 19-kDa-interacting protein 3) is a mitochondrial BH3-only protein that contributes to cell death through activation of the mitochondrial pathway of apoptosis. Bnip3 is also known to induce autophagy, but the functional role of autophagy is unclear.
Anne N Murphy, Åsa B Gustafsson
exaly   +3 more sources

EIF4A3-Induced circ-BNIP3 Aggravated Hypoxia-Induced Injury of H9c2 Cells by Targeting miR-27a-3p/BNIP3 [PDF]

Molecular Therapy - Nucleic Acids, 2020
Acute myocardial infarction (AMI) results from long-term diminished blood supply diminishment (ischemia) to the heart, and the main reason for ischemia is hypoxia. BCL2 interaction protein 3 (BNIP3) can be upregulated by hypoxia and participates in the mediation of hypoxia-activated apoptosis in cardiac myocyte death.
Li, Yansong, Ren, Shuhong, Xia, Jingwen, Wei, Yong, Xi, Yinhua   +4 more
exaly   +3 more sources

An unexpected journey for BNIP3

Autophagy
Mitophagy is a cellular process that enables the selective degradation of damaged, dysfunctional, or superfluous mitochondria. During mitophagy, specific proteins recognize and tag mitochondria for degradation. These tagged mitochondria are engulfed by specialized structures called phagophores that then mature into autophagosomes/mitophagosomes ...
José M Delgado, Christopher J Shoemaker
openaire   +2 more sources

BNIP3 Regulation of Intracellular Calcium

The FASEB Journal, 2016
Necrotizing enterocolitis is the most common gastrointestinal emergency affecting low‐birth weight premature infants, with an incidence between 3% and 10% in infants less than 1500 grams, and mortality ranging from 15% to 30%. The pathogenesis of NEC is not clearly defined, but is likely a multifactorial disease wherein intestinal ischemia and hypoxia ...
Jared Field, Simone da Silva Rosa, Wajihah Mughal, Yan Hai, Joseph Gordon, William L Diehl‐Jones   +5 more
openaire   +1 more source