Results 101 to 110 of about 13,811 (214)

Alternative BNIP3 splicing in alveolar rhabdomyosarcomal cells

, 2023
Several cellular phenotypes drive tumorigenesis in alveolar rhabdomyosarcoma. These phenotypes may be attenuated via treatment with non-steroidal antiinflammatory drugs, like aspirin, tolfenamic acid, and indomethacin, which interfere with intracellular ...
Fernando, Amy
core  

Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation

BMC Neuroscience, 2009
Background Caspase-independent apoptotic pathways are suggested as a mechanism for the delayed neuronal death following ischemic insult. However, the underlying signalling mechanisms are largely unknown.
Bean Jonathan C, Das Manas, Li Bo-Xing, Zhang Ming-Hai, Li Shu-Ji, Chen Ming, Zhao Shen-Ting, Kong Ji-Ming, Zhu Xin-Hong, Gao Tian-Ming   +9 more
doaj   +1 more source

Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015
Mitochondrial autophagy (mitophagy) is a core cellular activity. In this review, we consider mitophagy and related cellular processes and discuss their significance for human disease. Strong parallels exist between mitophagy and xenophagy employed in host defense. These mechanisms converge on receptors in the innate immune system in clinically relevant
openaire   +2 more sources

Expression of BNIP3 results in EndoG translocation.

, 2014
A, SH-SY5Y human neuroblastoma cells cells transfected with the full length BNIP3 or the mutant BNIP3ΔTM plasmids were immune-labeled with antibodies to BNIP3 and EndoG and counterstained with Hoechst 33342.
Jiming Kong (143823), Xiuwu Bian (181359), Xiaosha Zhang (667395)   +2 more
core   +1 more source

TRIM2 inhibits apoptosis by ubiquitinating BNIP3 to protect the intestine against ischemia-reperfusion injury in mice

Communications Biology
Intestinal damage following interrupted blood flow and its return (intestinal ischemia/reperfusion injury) is a serious medical problem occurring in various clinical situations.
Jinping Nie, Chao Mei, Aiping Wei, Yingjie Wang, Chenlu Fan, Yingjie Huang, Ming Jiang, Han Che, Tao Chen, Juan Tian, Yong Li, Xuan Huang, Xuekang Zhang   +12 more
doaj   +1 more source

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

EMBO Reports
Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of functional mitochondria. The SCFFBXL4 ubiquitin ligase complex suppresses mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors, and FBXL4 ...
Giang Thanh Nguyen-Dien, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew JK Jones, S Sean Millard, Dominic CH Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan   +17 more
doaj   +1 more source

6-Gingerol protects cardiocytes H9c2 against hypoxia-induced injury by suppressing BNIP3 expression

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Background Cardiomyocytes loss is the predominant pathogenic characteristic in the hypoxia-induced injury. Meanwhile, it has been corroborated that Bcl-2 E1B 19-KDa interacting protein 3 (BNIP3) provokes apoptosis and autophagy.
Qi Ren, Shaojun Zhao, Changjie Ren
doaj   +1 more source

C-terminal BNIP3 phosphorylation prevents damage to the mitochondrial network.

, 2015
(A) Representative examples of mitochondrial morphology, examined via transmission electron microscopy. Black arrows denote healthy, elongated mitochondria and white arrows denote rounded, swollen mitochondria. Scale bar represents 2 μm.
William A. Frazier (759144), Katherine E. Liu (759143)   +1 more
core   +1 more source

Coordinating BNIP3/NIX-mediated mitophagy in space and time

Biochemical Society Transactions
Mitochondria maintain organellar homeostasis through multiple quality control pathways, including the clearance of defective or unwanted mitochondria by selective autophagy. This removal of mitochondria, mitophagy, is controlled in large part by the outer mitochondrial membrane mitophagy receptors BNIP3 and NIX.
Natalie M. Niemi, Jonathan R. Friedman
openaire   +2 more sources

PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy

Cell Death and Disease
Mitophagy is a selective process that targets the damaged, dysfunctional, or superfluous mitochondria for degradation through autophagy. The SCFFBXL4 E3 ubiquitin ligase complex suppresses basal mitophagy by targeting BNIP3 and BNIP3L, two key mitophagy ...
Xiayun Xu, Yingji Chen, Siqi Fei, Xinyue Jiang, Xiaoting Zhou, Yimeng Xue, Yao Li, Shi-Min Zhao, Yan Huang, Chenji Wang   +9 more
doaj   +1 more source