Results 101 to 110 of about 19,441 (231)

Losartan Treatment Attenuates Tumor-induced Myocardial Dysfunction [PDF]

, 2015
Fatigue and muscle wasting are common symptoms experienced by cancer patients. Data from animal models demonstrate that angiotensin is involved in tumor-induced muscle wasting, and that tumor growth can independently affect myocardial function, which ...
Bicer, Sabahattin, Clark, Yvonne, Devine, Raymond D., Jing, Runfeng, McCarthy, Donna O., Reiser, Peter J., Stevens, Sarah C.W., Velten, Markus, Wold, Loren E., Youtz, Dane J.   +9 more
core   +2 more sources

Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice

Experimental Physiology, EarlyView.
Abstract This study investigated whether performing a translatable murine model of concurrent training after tumour induction affects adaptations in juvenile male and female tumour‐bearing mice. Male and female Balb/c mice were injected bilaterally with colon‐26 adenocarcinoma (C26) cells or PBS at 8 weeks of age.
Stavroula Tsitkanou, Pieter Koopmans, Calvin Peterson, Ana Regina Cabrera, Ruqaiza Muhyudin, Francielly Morena, Sabin Khadgi, Eleanor R. Schrems, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +10 more
wiley   +1 more source

Dual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX

Life Science Alliance
The mitochondrial phosphatase PPTC7 was previously found to suppress mitophagy, but the underlying mechanisms were unclear. Here, the authors show that PPTC7 dynamically localizes to the outer mitochondrial membrane to promote the turnover of the ...
Lianjie Wei, Mehmet Oguz Gok, Jordyn D Svoboda, Keri-Lyn Kozul, Merima Forny, Jonathan R Friedman, Natalie M Niemi   +6 more
doaj   +1 more source

Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study

Journal of Translational Medicine, 2012
Background This study was designed to determine the pattern and correlation between expression of the HIF-1α transcriptional targets TGM2 and BNIP3 in laryngeal cancer, and investigate the association of BNIP3 and TGM2 with clinical outcome in laryngeal ...
Jin Ting, Lin Huan-Xin, Lin Hui, Guo Li-Bing, Ge Nan, Cai Xiu-Yu, Sun Rui, Chen Wen-Kuan, Li Qiu-Li, Hu Wei-Han   +9 more
doaj   +1 more source

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells [PDF]

, 2009
Quercetin is a dietary bioflavonoid which has been shown to inhibit lens opacification in a number of models of cataract. The objectives of this study were to determine gene expression changes in human lens epithelial cells in response to quercetin and ...
Beyer-Mears, Castilla, Daub, Dery, Eady, Ferrara, Formica, Gilbert, Gong, Hains, Hanneken, Hertog, Hertog, Hollman, Jacques, Jeon, Jeong, Jeremy D. Rhodes, Julie Sanderson, Kampkotter, Klein, Klein, Knekt, Knekt, Lamson, Leopoldini, Leung, Li, Lija, Listgarten, Livak, Maiese, Manach, Park, Paul A. Kroon, Pauline Radreau, Reddan, Rice-Evans, Richard F. Mithen, Ridley, Sanderson, Sanderson, Schofield, Semenza, Semenza, Semenza, Shui, Shui, Shui, Spector, Tavani, Taylor, Triantafyllou, Triantafyllou, Truscott, Vandesompele, Wang, Wilson, Wormstone   +58 more
core   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway

Journal of Translational Medicine, 2019
Background The morbidity of nephrolithiasis is 2–3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis.
Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao, Yinghao Sun   +15 more
doaj   +1 more source

Main Pro-Apoptotic Member of BCL-2 Family Proteins-BAX [PDF]

, 2010
Programmed cell death (apoptosis) plays a vital role in the regulation of cellular homeostasis. Because of apoptosis fundamental importance, this process is highly regulated.
Kiliańska, Zofia, Żolnierczyk, Jolanta
core   +2 more sources

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Mammalian mitophagy – from in vitro molecules to in vivo models [PDF]

, 2017
The autophagic turnover of mitochondria, termed mitophagy, is thought to play an essential role in not only maintaining the health of the mitochondrial network, but also that of the cell and organism as a whole. We have come a long way in identifying the
Ganley, Ian G., McWilliams, Thomas G., Rodger, Catherine E.   +2 more
core   +2 more sources