Results 81 to 90 of about 13,811 (214)

Bnip3 dependent ventricular dilation and contractile dysfunction.

, 2015
(A) Bnip3 protein levels were determined in heart lysates from wild type (WT) and α-MHC-Bnip3 transgenic mice (Bnip3-TG) at the indicated ages. (B) Hematoxylin and eosin—stained coronal heart sections from 3 and 10 month old wild type (WT) and Bnip3-TG ...
Huilan Wang (789663), Keith A. Webster (201860), Maria G. Spiga (789664), Regina M. Graham (789665), Jianqin Wei (789661), Hong Yu (6528), John W. Thompson (458635), Kweku Appau (789662)   +7 more
core   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Stable deoxycycline inducible expression of BNIP3.

, 2018
HEK293 cells were engineered to stably co-express the Tet Repressor protein (TR) and tetracycline-inducible BNIP3 (TO-BNIP3) or beta-galactosidase (TO-β-gal) as described in the Materials & Methods.
Amandeep Singh (3511400), Spencer B. Gibson (416061), Miriam D. Shymko (5848277), Sachin Katyal (218909), Meghan Azad (3747673), David D. Eisenstat (5848280), Elizabeth S. Henson (589791)   +6 more
core   +1 more source

Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway

Journal of Translational Medicine, 2019
Background The morbidity of nephrolithiasis is 2–3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis.
Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao, Yinghao Sun   +15 more
doaj   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis

World Journal of Gastroenterology, 2007
To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer.To compare the ...
Masaharu, Ishida, Makoto, Sunamura, Toru, Furukawa, Masanori, Akada, Hiroko, Fujimura, Emiko, Shibuya, Shinichi, Egawa, Michiaki, Unno, Akira, Horii   +8 more
openaire   +2 more sources

Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa

Experimental Physiology, EarlyView.
Abstract Anorexia nervosa (AN) is a psychiatric disorder characterized by prolonged caloric restriction and skeletal muscle atrophy. Mitochondrial health is a key mediator of muscle function, yet the role of mitochondria during AN and following weight regain has not been investigated. The objective of this study was to evaluate mitochondrial capacities
Megan E. Rosa‐Caldwell, Toby L. Chambers, Lauren Breithaupt, Ruqaiza Muhyudin, Patience Salvalina Okoto, Sadie R. Thompson, Emily E. Rothacker, Claire Greenhill, Katie A. Wood, Kevin A. Murach, Sarah H. White‐Springer, Ursula B. Kaiser, Seward B. Rutkove   +12 more
wiley   +1 more source

Curcumin treatment improves Bnip3-TG cardiac performance.

, 2015
(A) Histone H3 acetylation (Ac-H3) levels in left ventricular lysates from wild type (WT) and Bnip3-TG mice were measured and quantified as described in Methods. (n = 3; * p < 0.05). Example images of short axis M-mode echo cardiograms of WT and Bnip3-TG
Huilan Wang (789663), Keith A. Webster (201860), Maria G. Spiga (789664), Regina M. Graham (789665), Jianqin Wei (789661), Hong Yu (6528), John W. Thompson (458635), Kweku Appau (789662)   +7 more
core   +1 more source

BNIP3 and NIX interact with Mieap.

, 2012
(A and B) The interaction between endogenous Mieap and NIX/BNIP3. The control A549 cells were γ-irradiated, and 2 days later, the cell lysates were purified from the mitochondrial fraction.
Daisuke Shinogi (186533), Hiroki Kamino (186541), Olga Goda (186536), Masaki Yoshida (5437), Ryuya Murai (186539), Noriaki Kitamura (186531), Hirofumi Arakawa (186544), Yasuyuki Nakamura (186527)   +7 more
core   +1 more source

Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia

The Journal of Physiology, EarlyView.
Abstract figure legend PoWeR training (11.5 weeks of voluntary wheel running with progressively increased resistance) before and during cancer attenuates muscle loss, limits tumour growth, drives a transition toward a more oxidative muscle phenotype (IIB‐to‐IIA shift), downregulates cachexia‐associated pathways and enhances mitochondrial performance in
Stavroula Tsitkanou, Pieter J. Koopmans, Ana Regina Cabrera, Nathan Serrano, Calvin S. Peterson, Ruqaiza Muhyudin, Zain B. Malik, Micah Goeke, Eleanor R. Schrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +13 more
wiley   +1 more source