Results 81 to 90 of about 19,441 (231)

The pharmacological regulation of cellular mitophagy [PDF]

, 2017
Small molecules are pharmacological tools of considerable value for dissecting complex biological processes and identifying potential therapeutic interventions.
A Brunet, A Cassidy-Stone, A Hoshino, A Hoshino, A Jain, A Kazlauskaite, A Khaminets, A Managò, A Orvedahl, A Sargsyan, A Schiavi, AE Alekseev, AT Dinkova-Kostova, AY Amerik, B Arun, B Bingol, B Maro, BJ Gurd, BM Kenwood, BS Padman, C Jo, C Jo, C Kondapalli, C Zhang, CA da Costa, CN Cunningham, CT Chu, D Liu, D Narendra, D Narendra, DA East, DA East, DP Narendra, EA Liberman, EF Fang, EH Kim, EH Kim, F Gao, F Ivanes, G Ashrafi, G Bellot, G Chen, G Wells, Geoff Wells, GFG Allen, GL McLelland, H Jia, H Sandoval, H Wei, H Zhang, HC Bertrand, HT Kang, I Kim, I Novak, IH Lee, J Gatliff, J Gatliff, J H Zhu, J Li, J Viotti, J Yun, J-H Zhu, JR Jangamreddy, K Grenier, K-S Park, KKK Chung, KM Holmström, L Liu, M Frank, M Fu, M Lazarou, M Mauro-Lizcano, M Mogi, M Redmann, Michelangelo Campanella, MV Tsiper, NA Khan, ND Georgakopoulos, Nikolaos D Georgakopoulos, NT Hertz, NV Kirienko, P Bai, Q Shen, R Huang, R Rupprecht, RD Sentelle, RJ Youle, RK Dagda, S Givvimani, S Kume, S Melser, S Rikka, SA Hasson, SJ Park, SM Jin, SY Jang, TM Durcan, W Duan, W Yue, X Qi, Y Kageyama, Y Wang, YP Yang, YQ Liu   +103 more
core   +4 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Receptor proteins in selective autophagy [PDF]

, 2012
Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates.
Behrends, Christian, Fulda, Simone
core   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210 [PDF]

, 2015
Background Autophagy participates in innate immunity by eliminating intracellular pathogens. Consequently, numerous microorganisms have developed strategies to impair the autophagic machinery in phagocytes.
de Oliveira Almeida Petersen, Antonio Luis, Frank, Benjamin, Marcu, Ana, Mottram, Jeremy C., Scholz, Claus Jürgen, Schurigt, Uta, Stigloher, Christian, Weber, Heike   +7 more
core   +3 more sources

BNIP3 is required for the differentiation of monocyte to macrophage

The FASEB Journal, 2006
The molecular mechanism of all‐ trans retinoic acid (ATRA)‐induced differentiation was under investigation. A pro‐apoptotic protein BNIP3 (Bcl‐2/adenovirus E1B 19 kda‐interacting protein 3) was thus identified by hybridization of human cDNA microarrays with cDNA derived from ATRA‐treated ...
Ching Li, Yung‐Cheng Tang, Pei‐Shan Hsieh, Biehuoy Shieh   +3 more
openaire   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Manganese (II) chloride leads to dopaminergic neurotoxicity by promoting mitophagy through BNIP3-mediated oxidative stress in SH-SY5Y cells

Cellular & Molecular Biology Letters, 2021
Background Manganese overexposure can induce neurotoxicity, lead to manganism and result in clinical manifestations similar to those of parkinsonism. However, the underlying molecular mechanism is still unclear. This study demonstrated that MnCl2 induces
Yanning Huang, Qiaolin Wen, Jinfeng Huang, Man Luo, Yousheng Xiao, Ruikang Mo, Jin Wang   +6 more
doaj   +1 more source

A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]

, 2015
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W., Kandarian, Susan C., Seto, Danielle N.   +2 more
core   +1 more source

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source