Results 31 to 40 of about 77,253 (305)

The role of the apoptosis-related protein BCL-B in the regulation of mitophagy in hepatic stellate cells during the regression of liver fibrosis

Experimental and Molecular Medicine, 2019
The clearance of activated hepatic stellate cells (HSCs) by apoptosis is critical for the reversibility of hepatic fibrosis. Mitochondrial homeostasis is regulated by mitophagy, which is an efficient way of clearing injured mitochondria that plays an ...
Qian Ding, Xiao-Li Xie, Miao-Miao Wang, Jie Yin, Jin-Mei Tian, Xiao-Yu Jiang, Di Zhang, Jing Han, Yun Bai, Zi-Jin Cui, Hui-Qing Jiang   +10 more
doaj   +1 more source

Mitophagy: Permitted by Prohibitin [PDF]

Current Biology, 2017
Autophagic responses specific for damaged or superfluous mitochondria are crucial for the maintenance of cellular and organismal homeostasis. Recent data demonstrate that components of the inner mitochondrial membrane that are unmasked upon outer membrane permeabilization facilitate the autophagic destruction of the organelle.
Lorenzo, Galluzzi, José Manuel, Bravo-San Pedro, Guido, Kroemer   +2 more
openaire   +2 more sources

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]

, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander, Baloyannis, Banchs, Bossy-Wetzel, Brockmann, Cassidy-Stone, Chang, Chen, Cho, Clark, D. C. Chan, de Brito, Delettre, Dodson, Exner, Fransson, Frezza, Gispert, H. Chen, Hollenbeck, Kim, Kim, Li, Liot, Lustbader, Macaskill, Meeusen, Milone, Mortiboys, Okamoto, Orr, Park, Parone, Popp, Reis, Suen, Ten Dijke, Trushina, Wang, Waterham, Wood-Kaczmar, Zuchner, Z  chner   +42 more
core   +3 more sources

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy [PDF]

, 2017
Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis.
A Jain, A Morelli, A Moustapha, AE Dikalova, AK Prasad, AP Joselin, B Bekdeser, B Bingol, B Mishra, C Hu, C Jo, D Faccenda, D Marcotte, D Narendra, DA East, DP Narendra, F Strappazzon, G Ashrafi, H Katayama, HC Bertrand, I Kim, J Gatliff, J Gatliff, J Lee, J Li, J Yan, J-A Pan, J-Y Lee, JD Clarke, JD Hayes, K Palikaras, KL Cheung, L Baird, L Mastrangelo, LC Gomes, M Frank, M Lazarou, MV Tsiper, N Wakabayashi, ND Georgakopoulos, Q Jiang, RC Scaduto, RLA Vries de, S Holm, S Kovac, S Li, S Melser, SE Dickinson, T Saito, X Xie, Y Ichimura, Y Katsuragi, Y Wang, Z-Y Jiang   +53 more
core   +4 more sources

Mitophagy in Pancreatic Cancer [PDF]

Frontiers in Oncology, 2021
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive solid malignancies, is characterized by the presence of oncogenic KRAS mutations, poor response to current therapies, prone to metastasis, and a low 5-year overall survival rate. Macroautophagy (herein referred to as autophagy) is a lysosome-dependent degradation system that forms a ...
Yangchun Xie, Jiao Liu, Rui Kang, Daolin Tang   +3 more
openaire   +3 more sources

Hepatitis C Virus Non-Structural Protein 5A (NS5A) Disrupts Mitochondrial Dynamics and Induces Mitophagy

Cells, 2019
Mitophagy is a selective form of autophagy, targeting damaged mitochondria for lysosomal degradation. Although HCV infection has been shown to induce mitophagy, the precise underlying mechanism and the effector protein responsible remain unclear. Herein,
Alagie Jassey, Ching-Hsuan Liu, Chun A. Changou, Christopher D. Richardson, Hsue-Yin Hsu, Liang-Tzung Lin   +5 more
doaj   +1 more source

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy

Redox Biology, 2020
Both iron metabolism and mitophagy, a selective mitochondrial degradation process via autolysosomal pathway, are fundamental for the cellular well-being.
Hao Wu, Huifang Wei, Di Zhang, Sheikh Arslan Sehgal, Dejiu Zhang, Xiaohui Wang, Yan Qin, Lei Liu, Quan Chen   +8 more
doaj   +1 more source

Characterization of immune features and immunotherapy response in subtypes of hepatocellular carcinoma based on mitophagy

Frontiers in Immunology, 2022
Mitophagy is suggested to be involved in tumor initiation and development; however, mitophagy heterogeneity in hepatocellular carcinoma (HCC) and its association with immune status and prognosis remain unclear.
Yanan Wang, Boshizhang Peng, Chun Ning, Shuya He, Huayu Yang, Yilei Mao, Lejia Sun, Lejia Sun   +7 more
doaj   +1 more source

Comparisons of ELISA and Western blot assays for detection of autophagy flux [PDF]

, 2017
We analyzed autophagy/mitophagy flux in vitro (C2C12 myotubes) and in vivo (mouse skeletal muscle) following the treatments of autophagy inducers (starvation, rapamycin) and a mitophagy inducer (carbonyl cyanide m-chlorophenylhydrazone, CCCP) using two ...
Choi, Yong-bok, Ju, Jeong-sun, Kim, June-hyun, Oh, Sung-hee, Weihl, Conrad C   +4 more
core   +3 more sources

Metabolic control of mitophagy

European Journal of Clinical Investigation, 2023
AbstractMitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival.
Zimmermann, Andreas, Madeo, Frank, Diwan, Abhinav, Sadoshima, Junichi, Sedej, Simon, Kroemer, Guido, Abdellatif, Mahmoud   +6 more
openaire   +2 more sources