Results 31 to 40 of about 50,060 (264)
Journal of Translational Medicine, 2020 Background We have reported that polydatin (PD) alleviates mitochondrial dysfunction in rat models of sepsis-induced acute kidney injury (SI-AKI), but the mechanism is not well understood.
Youguang Gao +8 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009 Concurrent mitochondrial elimination and autophagy in many systems has led to the proposal that autophagy is the main mechanism of mitochondrial turnover during development and under pathological conditions. The term mitophagy was coined to describe the selective removal of mitochondria by autophagy but the process itself is still contentious.
openaire +2 more sources
Receptor-mediated mitophagy [PDF]
Journal of Molecular and Cellular Cardiology, 2016 Mitochondria are essential organelles that supply ATP through oxidative phosphorylation to maintain cellular homeostasis. Extrinsic or intrinsic agents can impair mitochondria, and these impaired mitochondria can generate reactive oxygen species (ROS) as byproducts, inducing cellular damage and cell death.
Yamaguchi, Osamu +3 more
openaire +3 more sources
Measuring In Vivo Mitophagy [PDF]
Molecular Cell, 2015 Alterations in mitophagy have been increasingly linked to aging and age-related diseases. There are, however, no convenient methods to analyze mitophagy in vivo. Here, we describe a transgenic mouse model in which we expressed a mitochondrial-targeted form of the fluorescent reporter Keima (mt-Keima). Keima is a coral-derived protein that exhibits both
Sun, Nuo +10 more
openaire +2 more sources
Metabolic control of mitophagy
European Journal of Clinical Investigation, 2023 AbstractMitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival.
Zimmermann, Andreas +6 more
openaire +2 more sources
Mitophagy in hepatic ischemia-reperfusion injury [PDF]
Jichu yixue yu linchuangIn case of hepatic ischemia-reperfusion injury (HIRI), mitophagy is induced by multiple pathways such as PINK1/Parkin and mitophagy receptor, which is closely related to mitochondrial dynamic related protein. Mitophagy is a double-edged sword.
ZHANG Xiangxin, LI Wen
doaj +1 more source
Autophagy and mitophagy in hepatocarcinogenesis [PDF]
Molecular & Cellular Oncology, 2018 Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. In our recent studies, we found that autophagy, or more specifically mitophagy, was required to suppress TP53 and induce the expression of the transcription factor NANOG to maintain hepatic cancer stem cells and promote hepatocarcinogenesis.
Kai Liu +2 more
openaire +3 more sources
Mitophagy in Huntington's disease
Neurochemistry International, 2021 Huntington's disease (HD), as well as Parkinson's disease and Alzheimer's disease, belong to a group of neurodegenerative diseases characterized by common features, such as the progressive loss of neurons and the presence of pathogenic forms of misfolded protein aggregates.
I. Šonský +3 more
openaire +2 more sources
Experimental and Molecular MedicineMitophagy has been implicated in kidney function and related diseases. However, a direct analysis of mitophagy in kidney models, including disease models, remains notably lacking.
Kang-Min Lee +8 more
doaj +1 more source
FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia
Cell Death and Disease, 2022 Hypoxic pulmonary hypertension (PH) is a progressive disease characterized by hyper-proliferation of pulmonary vascular cells including pulmonary artery smooth muscle cells (PASMCs) and can lead to right heart failure and early death.
Ruxia Liu +10 more
doaj +1 more source