Results 31 to 40 of about 63,946 (250)

Mitophagy reporter mouse analysis reveals increased mitophagy activity in disuse-induced muscle atrophy

, 2021
Muscle disuse induces atrophy through increased reactive oxygen species (ROS) released from damaged mitochondria. Mitophagy, the autophagic degradation of mitochondria, is associated with increased ROS production.
Shun-Ichi, Yamashita, 1022373, Inoue, Keiichi, 1022374, Fukuda, Tomoyuki, Furukawa, Kentaro, Hata, Yuki, Kawada,, Ryu, Fujii, Yasuyuki, Sakagami, Junko, 1022371, 1022372, 1022370, 1022364, 1022365, 1022362, 1022363, 1022368, 1022369, 1022366, 1022367, Kanki, Tomotake, Yamabi, Masaki, Kyuuma, Masanao, Satoshi, Tsukamoto   +24 more
core   +1 more source

Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

Journal of Translational Medicine, 2020
Background We have reported that polydatin (PD) alleviates mitochondrial dysfunction in rat models of sepsis-induced acute kidney injury (SI-AKI), but the mechanism is not well understood.
Youguang Gao, Xingui Dai, Yunfeng Li, Guicheng Li, Xianzhong Lin, Chenmu Ai, Yuanyuan Cao, Tao Li, Bo Lin   +8 more
doaj   +1 more source

Mitophagy in atherosclerosis: from mechanism to therapy [PDF]

, 2023
Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways have been found to participate in different steps of mitophagy.
Luyao Huan, Song Sheng, Yanhong Zhang, Jiajun Weng, Fengqin Xu   +4 more
core   +1 more source

Mitophagy and the Brain

, 2020
Stress mechanisms have long been associated with neuronal loss and neurodegenerative diseases. The origin of cell stress and neuronal loss likely stems from multiple pathways. These include (but are not limited to) bioenergetic failure, neuroinflammation,
Natalie S. Swerdlow, Heather M. Wilkins
core   +1 more source

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy

Redox Biology, 2020
Both iron metabolism and mitophagy, a selective mitochondrial degradation process via autolysosomal pathway, are fundamental for the cellular well-being.
Hao Wu, Huifang Wei, Di Zhang, Sheikh Arslan Sehgal, Dejiu Zhang, Xiaohui Wang, Yan Qin, Lei Liu, Quan Chen   +8 more
doaj   +1 more source

Exploring mitophagy levels in Drosophila Malpighian tubules unveils the pivotal role of mitophagy in kidney function and diabetic kidney disease

Experimental and Molecular Medicine
Mitophagy has been implicated in kidney function and related diseases. However, a direct analysis of mitophagy in kidney models, including disease models, remains notably lacking.
Kang-Min Lee, Jihun Kim, Hye Lim Jung, Young Yeon Kim, Jihoon Lee, Yeon-Ju Lee, Eunhee Yoo, Hyi-Seung Lee, Jeanho Yun   +8 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Mitophagy-mediated immune evasion: Shared strategies of pathogensRisk/limitation box for mitochondria transplantation

Redox Biology
Mitophagy selectively eliminates dysfunctional mitochondria, playing a pivotal role in mitochondrial quality control and cellular homeostasis. Emerging evidence reveals that certain pathogens exploit mitophagy to evade host immune defenses.
Jun Li, Weijian Li, Dan Wang, Yulan Liu
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source