Results 31 to 40 of about 50,133 (121)

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

Cell Reports, 2017
Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer.
Elodie Villa, Emma Proïcs, Camila Rubio-Patiño, Sandrine Obba, Barbara Zunino, Jozef P. Bossowski, Romain M. Rozier, Johanna Chiche, Laura Mondragón, Joel S. Riley, Sandrine Marchetti, Els Verhoeyen, Stephen W.G. Tait, Jean-Ehrland Ricci   +13 more
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Mechanism and role of mitophagy in the development of severe infection

Cell Death Discovery
Mitochondria produce adenosine triphosphate and potentially contribute to proinflammatory responses and cell death. Mitophagy, as a conservative phenomenon, scavenges waste mitochondria and their components in the cell. Recent studies suggest that severe
Lixiu Ma, Tianyu Han, Yi-an Zhan
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Targeting cellular mitophagy as a strategy for human cancers

Frontiers in Cell and Developmental Biology
Mitophagy is the cellular process to selectively eliminate dysfunctional mitochondria, governing the number and quality of mitochondria. Dysregulation of mitophagy may lead to the accumulation of damaged mitochondria, which plays an important role in the
Yuming Dong, Xue Zhang
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Targeting MCL1 by UMI-77 to induce mitophagy alleviates renal tubular epithelial cells injury in acute kidney injury

Scientific Reports
Acute kidney injury (AKI) is a common clinical disease with complex pathophysiological processes and with high morbidity and mortality. Severe mitochondrial damages, such as mitochondrial swelling and fragmentation, disruption of membrane integrity, and ...
Xiaoyu Li, Zixian Li, Yongming Chen, Hongluan Wu, Yonghan Liu, Zhennan Ye, Qingqing Yang, Haicha Hou, Junfeng Hao, Ruigao Song, Huafeng Liu   +10 more
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Mitophagy regulates kidney diseases

Kidney Diseases
Background: Mitophagy is a crucial process involved in maintaining cellular homeostasis by selectively eliminating damaged or surplus mitochondria. As the kidney is an organ with a high dynamic metabolic rate and abundant mitochondria, it is particularly
Xiaolu Fan, Linlin Wu, Fengqi Wang, Dong Liu, Xufeng Cen, Hongguang Xia   +5 more
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HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation

Cell Stress, 2020
Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao, Catherine E. Rodger, George F. G. Allen, Simone Weidlich, Ian G. Ganley   +4 more
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Mitophagy in intracerebral hemorrhage: a new target for therapeutic intervention

Neural Regeneration Research
Intracerebral hemorrhage is a life-threatening condition with a high fatality rate and severe sequelae. However, there is currently no treatment available for intracerebral hemorrhage, unlike for other stroke subtypes.
Yiyang Chen, Wenxuan Tang, Xinqi Huang, Yumei An, Jiawen Li, Shengye Yuan, Haiyan Shan, Mingyang Zhang   +7 more
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Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

Nature Communications, 2019
Impaired removal of damaged mitochondria by mitophagy can activate innate immune signaling, but impact on virus replication remains unclear. Here the authors show that viral IRF-1 of human herpesvirus 8 activates mitophagy via interaction with the ...
Mai Tram Vo, Barbara J. Smith, John Nicholas, Young Bong Choi   +3 more
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Unlocking immune responses via mitophagy genes: A dual-pronged strategy against hematologic tumors

LabMed Discovery
Mitophagy plays a complex role in cancer biology, particularly in hematologic malignancies. It can promote tumor survival and drug resistance by removing damaged mitochondria and reducing mitochondrial reactive oxygen species (ROS) or conversely inhibit ...
Song-wei Liu, Zi-zhen Xu
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An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets

PLoS Biology, 2023
Failures in mitophagy, a process by which damaged mitochondria are cleared, results in neurodegeneration, while enhancing mitophagy promotes the survival of dopaminergic neurons.
Natalia Moskal, Naomi P. Visanji, Olena Gorbenko, Vijay Narasimhan, Hannah Tyrrell, Jess Nash, Peter N. Lewis, G. Angus McQuibban   +7 more
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