Results 21 to 30 of about 63,946 (250)

Lipid droplets promote efficient mitophagy [PDF]

, 2022
Mitophagy neutralizes defective mitochondria via lysosomal elimination. Increased levels of mitophagy hallmark metabolic transitions and are induced by iron depletion, yet its metabolic basis has not been studied in-depth.
Long, Maeve, Maeve Long, McWilliams, Thomas G., Thomas G. McWilliams   +3 more
core   +1 more source

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin [PDF]

, 2018
The Parkinson’s disease factors PINK1 and parkin are strongly implicated in stress-induced mitophagy in vitro, but little is known about their impact on basal mitophagy in vivo.
Clague, MJ, Whitworth, Alexander, Juliette J. Lee, Aitor Martinez Zarate, Alvaro Sanchez-Martinez, Mayor, Ugo, Cristiane Benincá, Ugo Mayor, Martinez Zarate, Aitor, Alexander J. Whitworth, Beninca, Cristiane, Sanchez-Martinez, Alvaro, Michael J. Clague, Lee, Juliette   +13 more
core   +1 more source

Relationship between ferroptosis and mitophagy in acute lung injury: a mini-review [PDF]

PeerJ
Acute lung injury (ALI) is one of the most deadly and prevalent diseases in the intensive care unit. Ferroptosis and mitophagy are pathological mechanisms of ALI. Ferroptosis aggravates ALI, whereas mitophagy regulates ALI.
Yunhua Cheng, Liling Zhu, Shuangxiong Xie, Binyuan Lu, Xiaoyu Du, Guanjiang Ding, Yan Wang, Linchong Ma, Qingxin Li   +8 more
doaj   +2 more sources

The role of the apoptosis-related protein BCL-B in the regulation of mitophagy in hepatic stellate cells during the regression of liver fibrosis

Experimental and Molecular Medicine, 2019
The clearance of activated hepatic stellate cells (HSCs) by apoptosis is critical for the reversibility of hepatic fibrosis. Mitochondrial homeostasis is regulated by mitophagy, which is an efficient way of clearing injured mitochondria that plays an ...
Qian Ding, Xiao-Li Xie, Miao-Miao Wang, Jie Yin, Jin-Mei Tian, Xiao-Yu Jiang, Di Zhang, Jing Han, Yun Bai, Zi-Jin Cui, Hui-Qing Jiang   +10 more
doaj   +1 more source

Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast

eLife, 2020
Degradation of mitochondria through mitophagy contributes to the maintenance of mitochondrial function. In this study, we identified that Atg43, a mitochondrial outer membrane protein, serves as a mitophagy receptor in the model organism ...
Tomoyuki Fukuda, Yuki Ebi, Tetsu Saigusa, Kentaro Furukawa, Shun-ichi Yamashita, Keiichi Inoue, Daiki Kobayashi, Yutaka Yoshida, Tomotake Kanki   +8 more
doaj   +1 more source

Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy [PDF]

, 2017
Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases.
Wong, Esther, Tan, Sijie, Sijie Tan, Esther Wong   +3 more
core   +1 more source

Mitophagy Regulates Neurodegenerative Diseases

, 2021
Mitochondria play an essential role in supplying energy for the health and survival of neurons. Mitophagy is a metabolic process that removes dysfunctional or redundant mitochondria. This process preserves mitochondrial health.
Xufeng Cen, Mengxin Zhou, Manke Zhang, Lingzhi Ye, Hongguang Xia   +4 more
core   +1 more source

The mitophagy pathway and its implications in human diseases

Signal Transduction and Targeted Therapy, 2023
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell death and programmed apoptotic, and are crucial for cell metabolism and survival.
Shouliang Wang, Haijiao Long, Lianjie Hou, Baorong Feng, Zihong Ma, Ying Wu, Yu Zeng, Jiahao Cai, Da-wei Zhang, Guojun Zhao   +9 more
doaj   +1 more source

Restriction of trophic factors and nutrients induces PARKIN expression [PDF]

, 2011
Parkinson's disease (PD) is the most frequent neurodegenerative movement disorder and manifests at old age. While many details of its pathogenesis remain to be elucidated, in particular the protein and mitochondrial quality control during stress ...
Klinkenberg, Michael, Auburger, Georg, S. Gispert, Braun, Isabelle, M. Klinkenberg, Dominguez Bautista, Jorge Antolio, M. Jendrach, Gispert, Suzana, G. Auburger, J. A. Dominguez-Bautista, I. Braun, Jendrach, Marina   +11 more
core   +1 more source

Hepatitis C Virus Non-Structural Protein 5A (NS5A) Disrupts Mitochondrial Dynamics and Induces Mitophagy

Cells, 2019
Mitophagy is a selective form of autophagy, targeting damaged mitochondria for lysosomal degradation. Although HCV infection has been shown to induce mitophagy, the precise underlying mechanism and the effector protein responsible remain unclear. Herein,
Alagie Jassey, Ching-Hsuan Liu, Chun A. Changou, Christopher D. Richardson, Hsue-Yin Hsu, Liang-Tzung Lin   +5 more
doaj   +1 more source