Results 21 to 30 of about 50,060 (264)
Mitophagy in metabolic syndrome
The Journal of Clinical Hypertension, 2023 AbstractMetabolic syndrome (MS), a chronic and non‐communicable pathological condition, is characterized by a constellation of clinical manifestations including insulin resistance, abdominal adiposity, elevated blood pressure, and perturbations in lipid metabolism.
Mei‐Qi Miao, Yu‐Bo Han, Li Liu
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Mitophagy: Permitted by Prohibitin [PDF]
Current Biology, 2017 Autophagic responses specific for damaged or superfluous mitochondria are crucial for the maintenance of cellular and organismal homeostasis. Recent data demonstrate that components of the inner mitochondrial membrane that are unmasked upon outer membrane permeabilization facilitate the autophagic destruction of the organelle.
Lorenzo, Galluzzi +2 more
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Mitophagy in Antiviral Immunity [PDF]
Frontiers in Cell and Developmental Biology, 2021 Mitochondria are important organelles whose primary function is energy production; in addition, they serve as signaling platforms for apoptosis and antiviral immunity. The central role of mitochondria in oxidative phosphorylation and apoptosis requires their quality to be tightly regulated.
Hongna Wang +8 more
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Experimental and Molecular Medicine, 2019 The clearance of activated hepatic stellate cells (HSCs) by apoptosis is critical for the reversibility of hepatic fibrosis. Mitochondrial homeostasis is regulated by mitophagy, which is an efficient way of clearing injured mitochondria that plays an ...
Qian Ding +10 more
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eLife, 2020 Degradation of mitochondria through mitophagy contributes to the maintenance of mitochondrial function. In this study, we identified that Atg43, a mitochondrial outer membrane protein, serves as a mitophagy receptor in the model organism ...
Tomoyuki Fukuda +8 more
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Mitophagy in Pancreatic Cancer [PDF]
Frontiers in Oncology, 2021 Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive solid malignancies, is characterized by the presence of oncogenic KRAS mutations, poor response to current therapies, prone to metastasis, and a low 5-year overall survival rate. Macroautophagy (herein referred to as autophagy) is a lysosome-dependent degradation system that forms a ...
Yangchun Xie +3 more
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The many faces of mitophagy [PDF]
EMBO reports, 2014 Failure to maintain mitochondrial integrity is linked to age‐related conditions, such as neurodegeneration. Two genes linked to Parkinson's disease, PINK1 and Parkin, play a key role in targeting the degradation of dysfunctional mitochondria (mitophagy).
Ivatt, Rachael M, Whitworth, Alexander J
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The mitophagy pathway and its implications in human diseases
Signal Transduction and Targeted Therapy, 2023 Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell death and programmed apoptotic, and are crucial for cell metabolism and survival.
Shouliang Wang +9 more
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Cells, 2019 Mitophagy is a selective form of autophagy, targeting damaged mitochondria for lysosomal degradation. Although HCV infection has been shown to induce mitophagy, the precise underlying mechanism and the effector protein responsible remain unclear. Herein,
Alagie Jassey +5 more
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Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy
Redox Biology, 2020 Both iron metabolism and mitophagy, a selective mitochondrial degradation process via autolysosomal pathway, are fundamental for the cellular well-being.
Hao Wu +8 more
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